Design, synthesis and preclinical evaluation of muscarine receptor antagonists via a scaffold-hopping approach

Unveiling the anti-echinococcal efficacy of amide-based compounds: An in-silico and in-vitro study

“…Several studies on different drug molecules have been reported which depicted that physico-chemical (especially lipophilicity logP) and electronic (e.g. binding affinity) properties exhibit a significant influence on biological activity [ 29 , 30 ]. Various physico-chemical and electronic parameters were considered, revealing that compounds with lower predicted lipophilicity values were within the acceptable limits of Lipinski's rule of five, indicating good membrane permeating inhibitors.…”