Design, synthesis, and spectroscopic study of some new flavones containing two azo linkages

Ayoob, Mzgin M.; Hawaiz, Farouq E.

doi:10.1063/1.5004294

Cited by 4 publications

(2 citation statements)

References 23 publications

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“…The results were recorded depending on the diameter of inhibition of bacterial growth in mm as shown in Table 1. 13 13 Highly reactive: (inhibition zone < 30mm), Active (inhibition zone 20mm -30mm) Slightly active (inhibition zone 14mm -20mm) [22].…”

Section: Biological Screening Of Some Of the Synthesized Compoundsmentioning

confidence: 99%

“…The two main reactions used in this research are diazo coupling and Schiff base formation, these two reactions were very important in that they can be exploited to link reactive aromatic molecules easily. The aromatic molecules containing more than one functional group could be used to synthesize multi-functional larger molecules which may tend to increase their biological activity [22]. FT-IR for compounds (H 25 -H 28 ) showed no bands in the C=O stretching region signifying its conversion into an imine group.…”

Section: Scheme For the Preparation Of Schiff's Bases Of Salicylaladementioning

confidence: 99%

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Synthesis, Characterization and Biological Evaluation of Some Azo and Azo-Schiff Compounds

Azeez¹,

Al-kadhimi²,

Tapabashi³

2019

KUJSS

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This work involves the preparation of some new azo and azo-Schiff compounds derived from benzothiophene, dibenzothiophene, and diamines (1, 5-diaminonaphthalene, and thiocarbohydrazide). Azo compounds of benzothiophene and dibenzothiophene have been prepared using different solvents to enhance the miscibility of the polar aqueous solution of the diazonium salt and the slightly polar benzothiophene and dibenzothiophene. The Schiff's bases have been synthesized by the condensation reaction of carbonyl compound with the diamines. FT-IR has been used to identify the prepared compounds, whereas 1 H-NMR and 13 C-NMR were used to identify some others.

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Section: Biological Screening Of Some Of the Synthesized Compoundsmentioning

confidence: 99%

Section: Scheme For the Preparation Of Schiff's Bases Of Salicylaladementioning

confidence: 99%

Synthesis, Characterization and Biological Evaluation of Some Azo and Azo-Schiff Compounds

Azeez¹,

Al-kadhimi²,

Tapabashi³

2019

KUJSS

View full text Add to dashboard Cite

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Synthesis, Anti-Bacterial and Anti-Oxidant Activity of Azo-Oxazolone and Their Ring Opening Azo-Benzamide Derivatives

Ayoob

Samad

Dege

et al. 2021

COS

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Aims: This article describes the controlled synthesis and characterization of azo oxazolone as multifunctional group in which contain Carbonyl, imine and carbon double bond carbon bond, and their ring opening to azo-benzamide derivative in fast reaction( 5<min>90%). Objective: UV, IR, proton-NMR, C13-NMR, Elemental analysis and MS spectrometry all synthesized compounds were tested for antibacterial and antioxidant activity. Materials and Methods: Azo benzamide derivatives were prepared by ring opening of azo oxazolone. Results and Discussion: Chemically structures of synthesized compounds were characterized upon UV, IR, proton-NMR, C13-NMR, Elemental analysis and MS spectrometry. Conclusion: The oxazolone and benzamide compounds (5a, 5c, 5f, 5h, 5j) screened by diffusion method, the results of tested ciprofloxacin as standard. according to the results the tested compound exhibits more resist to the Escherichia coli than the Staphylococcus aureus . The highest activity of all compound at 800 µg against both types of bacteria, compound (5c and 5j) have higher activity (inhibition zone 32mm) than the ciprofloxacin (inhibition zone 28mm) against Escherichia coli. But compound (5j) in all concentration was in active against Staphylococcus aureus. Compound (5a, 5c, 5f and 5h) have high activity against E.coli. compound (5c) have low activity in all different concentration. Others: Also the product compound tested for its anti-oxidant activity by both DPPH and FRAP method. The result showed that the some compound have moderate anti-oxidant activity in comparison with ascorbic acid as control typically the compounds bearing OCH3and OCH2CH3 group.

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Synthesis, Antimicrobial and Antioxidant Activity of Some New Pyrazolines Containing Azo Linkages

Hussein

2024

COS

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Background: Pyrazolines and azo-pyrazolines are influential groups of heterocyclic compounds with two nitrogen atoms inside the five-membered ring. They play an important role in a wide range of biological processes, such as antifungal, antioxidant, antimalarial and other antimicrobial activities. Objective: The main objective of this study is to synthesize some new heterocyclic compounds with antioxidant and antimicrobial activity. Methods: One-pot three components and traditional synthesis of new azo-pyrazoline compounds were achieved in this work. The preparation process has been started by diazotizing 4-(6-methylbenzothiazol-2-yl) benzamine and its coupling reaction with 4-hydroxy acetophenone producing azo-acetophenone, followed by benzylation with benzyl chloride to form the starting material, azo-benzyloxy acetophenone. A series of substituted benzaldehydes were reacted with the latter compound via one pot and classical methods, forming new chalcones containing azo linkages and benzyloxy moieties, which were then converted into new target azo-pyrazoline derivatives. Results: The structures of the synthesized compounds were confirmed by spectroscopic techniques using FT-IR, 1H-NMR, 13C-NMR, and 13C- DEPT- 135 spectra. Finally, the synthesized compounds were screened for their antioxidant and antimicrobial activities against Staphylococcus aureus and Escherichia coli. Conclusion: Overall, the one-pot three-component synthesis of pyrazoline compounds generally provides advantages in terms of efficiency, simplicity, and time-consumption compared to classical synthesis methods. Hence, the study advocates the one-pot method because it eliminates the tedious process of making chalcones, which takes time, materials, and unnecessary effort. Therefore, this is the most convenient and effective approach to green chemistry.

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Design, synthesis, and spectroscopic study of some new flavones containing two azo linkages

Cited by 4 publications

References 23 publications

Synthesis, Characterization and Biological Evaluation of Some Azo and Azo-Schiff Compounds

Synthesis, Characterization and Biological Evaluation of Some Azo and Azo-Schiff Compounds

Synthesis, Anti-Bacterial and Anti-Oxidant Activity of Azo-Oxazolone and Their Ring Opening Azo-Benzamide Derivatives

Synthesis, Antimicrobial and Antioxidant Activity of Some New Pyrazolines Containing Azo Linkages

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