Design, synthesis and structure activity relationships of spirocyclic compounds as potent CCR1 antagonists

Synthesis of Trifluoromethyl‐Substituted 3‐Azabicyclo[n.1.0]alkanes: Advanced Building Blocks for Drug Discovery

“…We next cleaved the N ‐Boc group in 10 by HCl/methanol to afford 4‐(trifluoromethyl)pyrrolidine ( 11· HCl). During the last decade, amine 11 has become popular in both drug discovery and agrochemistry projects,20 but we only recently comprehensively described its synthesis 21,9b…”