Design, Synthesis, and Structure—Activity Relationships of 3,4‐Dihydropyridopyrimidin‐2(1H)‐one Derivatives as a Novel Class of Sodium/Calcium Exchanger Inhibitor.

Abstract

Fused pyrimidine derivatives R 0515 Design, Synthesis, and Structure-Activity Relationships of 3,4-Dihydropyridopyrimidin-2(1H)-one Derivatives as a Novel Class of Sodium/Calcium Exchanger Inhibitor. -Compound (IX) shows the highest ion-exchanger blocking activity of all derivatives tested. -(HASEGAWA*, H.; MURAOKA, M.; OHMORI, M.; MATSUI, K.; KOJIMA, A.; Chem.