Design, synthesis and vasorelaxant evaluation of novel coumarin–pyrimidine hybrids

Dicumarol inhibits PDK1 and targets multiple malignant behaviors of ovarian cancer cells

“…Coumarins are a family of compounds widely distributed in plants, bacteria, and fungi; they present various pharmacological properties, including antibacterial [21], antimutagenic [22], anti-inflammatory [23], anticoagulant [24–26], antithrombotic [27, 28], and anticancer activities [29]. In cancers, coumarins target a number of pathways or signaling molecules, including cell cycle progression, angiogenesis, heat shock protein 90, telomerase, mitosis, carbonic anhydrase, monocarboxylate transporters, aromatase, and sulfatase [30].…”

Synthesis and anticancer activity of some 8-substituted-7-methoxy-2H-chromen-2-one derivatives toward hepatocellular carcinoma HepG2 cells

“…were prepared by conventional Claisen-Schmidt condensation reaction of 5 with (un)-substituted-arylaldehydes in the presence of 10 % sodium hydroxide in ethanol (Scheme 1) [50].…”

Design, synthesis of benzocoumarin-pyrimidine hybrids as novel class of antitubercular agents, their DNA cleavage and X-ray studies

“…It was also envisaged that pyrimidine and coumarin pharmacophores, if linked together would generate novel molecular templates which are likely to exhibit interesting biological properties in animal models [42]. In particular, those pyrimidine linked to coumarin have been reported to possess anti-pyretic [42], analgesic [42,43], anti-microbial [44], vascorelaxant [45] and anticancer [46,47] properties.…”