Design, synthesis, antibacterial and QSAR studies of benzimidazole and imidazole chloroaryloxyalkyl derivatives

Khalafi-Nezhad, Ali; Rad, Mohammad Navid Soltani; Mohabatkar, Hassan; Asrari, Zeinab; Hemmateenejad, Bahram

doi:10.1016/j.bmc.2005.01.014

Cited by 177 publications

(87 citation statements)

References 32 publications

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“…1 There is a real need for discovery of new compounds endowed with antimicrobial activity, possibly acting through mechanisms of actions, which are distinct from those of well known classes of antimicrobial agents to which many clinically relevant pathogens are now resistant. 2 Hydrazide analogues also possess other biological activities like anticonvulsant, 3 antidepressant, 4 anti-inflammatory, 5 antimalarial, 6 antimycobacterial, 7 anticancer 8 and antimicrobial [9][10][11][12] activities. QSAR is one of the oldest and most widely used methods in computational drug design.…”

Section: Introductionmentioning

confidence: 99%

Substituted benzoic acid benzylidene/furan-2-yl-methylene hydrazides: synthesis, antimicrobial evaluation and QSAR analysis

Kumar¹,

Narasimhan²,

Sharma³

2008

Arkivoc

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Development of new antimicrobial agents is increasingly important due to the resistance of microbes to the known antimicrobial drugs. In the present work substituted benzoic acid hydrazides (1-10) were condensed with substituted aromatic and heteroaromatic aldehydes to yield the target products (11)(12)(13)(14)(15)(16)(17)(18)(19)(20). The synthesized compounds were tested in vitro for their antimicrobial activity against Gram positive, Gram negative bacterial and fungal species. The QSAR analysis applied to determine the correlation of antimicrobial activity of substituted hydrazide derivatives with their physicochemical properties indicated the importance of electronic parameters, dipole moment (µ) and energy of lowest unoccupied molecular orbital (LUMO) in describing antibacterial and antifungal activity respectively.

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Section: Introductionmentioning

confidence: 99%

Substituted benzoic acid benzylidene/furan-2-yl-methylene hydrazides: synthesis, antimicrobial evaluation and QSAR analysis

Kumar¹,

Narasimhan²,

Sharma³

2008

Arkivoc

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“…The Schi -base compounds with benzimidazole moiety [3,4] and their metal complexes [5,6] also have been reported on their broad biological activities. The title compound is a polydentate Schi -base with benzimidazole and steric hindrance synthesized in a convenient approach.…”

Section: Discussionmentioning

confidence: 99%

Crystal structure of 2-methoxy-6-(((2-(1-methyl-1H-benzo[d] imidazol-2-yl)phenyl)imino)methyl)phenol — ethanol (1/1), C₂₄H₂₅N₃O₃

Zhang

Zhou

et al. 2016

Zeitschrift Für Kristallographie - New Crystal Structures

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C 24 H 25 N 3 O 3 , monoclinic, (no. 14), a = 10.2246(7) Å, b = 21.2529(7) Å, c = 10.6924(6) Å, CCDC no.: 1447026The crystal structure is shown in the gure. Tables 1-3 contain details of the measurement method and a list of the atoms including atomic coordinates and displacement parameters. Source of materialThe title compound was synthesized by the condensation of 2-(1-methyl-1H-benzo[d]imidazol-2-yl)aniline and 2-hydroxy-3-methoxybenzaldehyde (o-vanillin) (molar ratio 1:1)

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“…We will continue this work in the future by a quantitative calculation. [60] A quantitative characterization based on computed physicochemical property profiles such as Polarizability [29], Partition Coefficient (log P) [30][31][32][33], Hydration Energy [34][35][36], Molecular Volume [37], Molecular Surface and Molecular Mass [38] has been conducted. The physicochemical parameters used in the study are described below.…”

Section: Study Of Structure -Activity Relationships For 16-memberementioning

confidence: 99%

Conformational Analysis, Substituent Effect and Structure Activity Relationships of 16-Membered Macrodiolides

Mazri

Belaidi

Kerassa

et al. 2014

ILCPA

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Electronic structures, Conformational Analysis, effect of the substitution and structure activity Relationships for macrodiolides, have been studied by PM3 and ab initio methods. In the present work, the calculated values, namely net charges, bond lengths, MESP, dipole moments, electronaffinities, heats of formation, drug-likeness and QSAR properties, are reported and discussed in terms of the biological activity of macrodiolides.

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Design, synthesis, antibacterial and QSAR studies of benzimidazole and imidazole chloroaryloxyalkyl derivatives

Cited by 177 publications

References 32 publications

Substituted benzoic acid benzylidene/furan-2-yl-methylene hydrazides: synthesis, antimicrobial evaluation and QSAR analysis

Substituted benzoic acid benzylidene/furan-2-yl-methylene hydrazides: synthesis, antimicrobial evaluation and QSAR analysis

Crystal structure of 2-methoxy-6-(((2-(1-methyl-1H-benzo[d] imidazol-2-yl)phenyl)imino)methyl)phenol — ethanol (1/1), C₂₄H₂₅N₃O₃

Conformational Analysis, Substituent Effect and Structure Activity Relationships of 16-Membered Macrodiolides

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Design, synthesis, antibacterial and QSAR studies of benzimidazole and imidazole chloroaryloxyalkyl derivatives

Cited by 177 publications

References 32 publications

Substituted benzoic acid benzylidene/furan-2-yl-methylene hydrazides: synthesis, antimicrobial evaluation and QSAR analysis

Substituted benzoic acid benzylidene/furan-2-yl-methylene hydrazides: synthesis, antimicrobial evaluation and QSAR analysis

Crystal structure of 2-methoxy-6-(((2-(1-methyl-1H-benzo[d] imidazol-2-yl)phenyl)imino)methyl)phenol — ethanol (1/1), C24H25N3O3

Conformational Analysis, Substituent Effect and Structure Activity Relationships of 16-Membered Macrodiolides

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Crystal structure of 2-methoxy-6-(((2-(1-methyl-1H-benzo[d] imidazol-2-yl)phenyl)imino)methyl)phenol — ethanol (1/1), C₂₄H₂₅N₃O₃