Design, synthesis, anticancer, antimicrobial activities and molecular docking studies of theophylline containing acetylenes and theophylline containing 1,2,3-triazoles with variant nucleoside derivatives

Clinical and social aspects of dysmenorrhea development

“…Synthesis of 7-ethylxanthinyl-8-aminoalkanoic acids (3)(4)(5)(6)(7)(8)(9)(10). A mixture of 0.01 mol of 8-brom-7-ethylxanthine 1 or 2, 0.025 mol of the corresponding amino acid, 2.1 g (0.025 mol) of NaHCO 3 , 15 ml of water and 25 ml of DMF are boiled for 6 hours, cooled; 50 ml of water are added, then the mixtures are filtered.…”

“…Despite their effectiveness, they cause a number of side effects, and thus the search for new antimicrobial and antifungal agents is currently one of the problems of pharmaceutical science of current interest. Literary data suggest that xanthine derivatives exhibit activity in relation to some strains of pathogenic microorganisms and fungi [1][2][3][4][5][6].…”

An Overview of Recent Advances in the Applications of Click Chemistry in the Synthesis of Bioconjugates with Anticancer Activities

“…Theophylline, also known as 1,3‐dimethylxanthine is a member of the xanthine family and illustrates various biological activities such as bronchospasmolytic, anti‐cancer and circulatory blood system activity …”

Recent Synthetic Approaches Towards Biologically Potent Derivatives/Analogues of Theophylline

“…Because of the biological significances of theophylline, nucleosides, and 1,2,3‐triazole derivatives, Ruddarraju et al . in 2016 synthesized theophylline derivatives having acetylene and theophylline containing 1,2,3‐triazole nucleoside hybrids as anticancer agents against four different cell lines in humans. For the synthesis of theophylline containing acetylene derivatives, alkylation of theophylline 4 was carried out with ethyl 2‐bromoacetate to give the compound 228 in the excellent yield (84%), while on alkylation under Mitsunobu conditions, product 230 was synthesized in 50% yield by carrying out the reaction of theophylline with ethyl‐2‐hydroxy propanoate 229 in the presence of triphenylphosphine and diisopropyl azodicarboxylate.…”