2020
DOI: 10.1016/j.bmcl.2020.127438
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Design, synthesis, biological evaluation and molecular docking of new uracil analogs-1,2,4-oxadiazole hybrids as potential anticancer agents

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Cited by 41 publications
(23 citation statements)
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“…Several anticancer drugs usually result in the course of cell cycle arrest at a particular checkpoint, which results in the induction of the apoptotic process. [46][47][48][49] To evaluate the cell cycle profile of HT-1080 cells after treatment with the selected compounds, we performed cell cycle analysis by flow cytometry. For this study, HT-1080 cells were incubated with 10 μM of the compounds 2 b and 7 b for 24 hours (Figure 5).…”
Section: Investigation Of Cell Cyclementioning
confidence: 99%
“…Several anticancer drugs usually result in the course of cell cycle arrest at a particular checkpoint, which results in the induction of the apoptotic process. [46][47][48][49] To evaluate the cell cycle profile of HT-1080 cells after treatment with the selected compounds, we performed cell cycle analysis by flow cytometry. For this study, HT-1080 cells were incubated with 10 μM of the compounds 2 b and 7 b for 24 hours (Figure 5).…”
Section: Investigation Of Cell Cyclementioning
confidence: 99%
“…Meanwhile, ligand 10 showed more affinity towards the caspase‐3 with a free energy of binding of −9.07 kcal/mol, which following the obtained experimental results. Indeed, alongside the after‐mentioned interactions for ligand 9 , substituted N‐phenyl 10 showed two additional hydrogen bonds with amino acids Cys163 and Gln161, which are essential for caspase‐3 activation [34,35,37] . The study of interactions showed that each pharmacophore of compounds 9 and 10 interacted with amino acids of caspase‐3 proteins.…”
Section: Resultsmentioning
confidence: 93%
“…To further examine the potential of the selected compounds in inducing growth inhibition of HT‐1080 cells via alternations in cell cycle arrest, we evaluated the effect of 9 and 10 on the cell cycle progression. Thus, HT‐1080 lines were incubated with 20 μM of 9 and 10 for 24h, then analyzed by the flow cytometry analysis [34] . The DNA histograms and cell cycle phase distribution are exposed in Figure 5.…”
Section: Resultsmentioning
confidence: 99%
“…(R)-carvone oxime O-propargyl ether 7 and the monoterpenic1,2,3-triazoles 9a – h were screened for their cell growth inhibitory effects, usingan MTS assay in four human cancer cell lines HT-1080 (fibrosarcoma), A549 (lung carcinoma) and two breast carcinomas (MCF-7 and MDAMB-231) [ 61 , 62 , 63 ]. The topoisomerase II inhibitor doxorubicin (DOX) was used as a positive control.…”
Section: Resultsmentioning
confidence: 99%