Design, synthesis, characterization and antibacterial properties of copper(II) complexes with chromone‐derived compounds

Abstract

A new series of six chromone-derived compounds and their Cu(II) complexes was synthesized and characterized by their physical, spectral and analytical data The elemental analysis data of the complexes agree well with the proposed composition of the compounds, which were found to be dimeric in nature with two hydrazine molecules bridging the two copper atoms through coordination. The ligands and their Cu(II) complexes were screened for their in-vitro antibacterial activity against four Gram-negative (Escherichia coli, Pseudomonas aeruginosa, Salmonella typhi, Shigella flexneri) and two Gram-positive (Bacillus subtilis, Staphylococcus aureus) bacterial strains by the agar-well diffusion method. The ligands were found to exhibit either no or low to moderate activities against one or more of the bacterial species, whereas all the metal complexes exhibited moderate to high activities against different bacterial species. The ligands which were inactive before complexation turned active and less active ones became more active upon coordination with copper ions. Overall, the complexes 7-12 showed comparatively much higher activities than the ligands.

Metal-based carboxamide-derived compounds endowed with antibacterial and antifungal activity

“…However the complex (5) possessed moderate activity (46-52%) against (a) and (c)-(f) bacterial strains and weak activity (33%) against strain (b). Conclusively, the ligands (L (12), which showed that the activity is enhanced 34 upon coordination.…”

“…The bond lengths and angles are all present in the expected 34 range. The molecular structure of complex (2) shows that it exists as dimer form in asymmetric unit (Figure 3).…”

Synthesis, Characterization and DNA Cleavage of Copper(II) Complex with D,L-Dithiothreitol

“…Chohan et al reported that in copper(II) complexes with chromone-derived compounds, Karl Fisher titration values do not equate with any whole number of water molecules [20].…”

Antibacterial, Cytotoxic Studies and Characterization of Some Newly Synthesized Symmetrical N3,N3′‐Bis(disubstituted)isophthalyl‐bis(thioureas) and Their Cu(II) and Ni(II) Complexes

“…Antibacterial Assay. In vitro antibacterial activity of all the synthesized compounds was tested against six different bacterial strains [26]. The compounds (L 1 -L 5 ) and their metal(II) complexes exhibited potential activity against all tested bacteria with highest inhibition zones ( Table 2).…”