Design, Synthesis, Characterization, and Antimicrobial Screening of Novel Indazole Bearing Oxadiazole Derivatives

Abstract

Ethyl 2‐(2,6‐dioxocyclohexyl)‐2‐oxoacetate was prepared by reacting cyclohexane‐1,3‐dione (1) and diethyl oxalate (2) with the help of sodium ethoxide in ethanol at 0–5°C. Subsequent treatment of ethyl 2‐(2,6‐dioxocyclohexyl)‐2‐oxoacetate with hydrazine hydrate in ethanol resulted into ethyl 4‐oxo‐4,5,6,7‐tetrahydro‐2H‐indazole‐3‐carboxylate while without solvent in excess hydrazine hydrate on reflux resulted into 4‐oxo‐4,5,6,7‐tetrahydro‐2H‐indazole‐3‐carbohydrazide (3). The synthesis of novel indazole bearing oxadiazole derivatives (ODZ 01 to 16) has been achieved by the reaction of hydrazide of 2H‐indazole (3) with acid (4a, 4b, 4c, 4d, 4e, 4f, 4g, 4h, 4i, 4j, 4k, 4l, 4m, 4n, 4o, 4p) in the presence of POCl3, and the antimicrobial activity of synthesized novel compounds has been studied.

1‐Benzyl‐1H‐indazol‐3‐ol Copper(II) Derivatives as Anticancer Agents: In‐vitro Interaction with DNA/BSA, DFT, Molecular Docking and Cytotoxicity on MCF7 Cells

“…Numerous indazole derivatives have demonstrated potent antimicrobial actions against various microorganisms, including bacteria and fungi. [21][22][23][24][25] A few indazole derivatives have been established thoroughly while reflecting significant cytotoxic properties. [26][27][28] Various 2-substituted indazoles derivatives and their metal complexes are known to operate as potential anticancer agents have also been found in several investigations possessing effective cytotoxicity e. g. indazoles compounds possess cytotoxic properties and interfere with DNA topoisomerase I proactively by treating breast cancer (MCF7) impacts.…”

“…Indazole is well known to exhibit variety of biological actions. Numerous indazole derivatives have demonstrated potent antimicrobial actions against various microorganisms, including bacteria and fungi [21–25] . A few indazole derivatives have been established thoroughly while reflecting significant cytotoxic properties [26–28] .…”