Design, Synthesis, DFT Studies and Anticancer Activity of Novel Metal Complexes Containing 1,3,5-triazino[1,2-a]benzimidazole Moiety Using Microwave as an Approach for Green Chemistry

Hassan, Ali M.; Heakal, Bassem H.; Khamis, Hamdy; Younis, Ahmed; Hassan, Gamal Abdel Naeem; Marzouk, Emad; Abdelmoaz, Miral Ahmed

doi:10.21608/ejchem.2020.29618.2639

Cited by 6 publications

(4 citation statements)

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“…Manual grinding has been developed into many automated methods that apply reactions by friction force, such as grinding by rotating mortar (45) and high-speed ball milling (46). Many other technologies have resorted to using energy to conduct reactions such as microwave-assisted reactions (47), reactions under ultrasonic waves (sonochemistry) (48), photochemistry, and electrochemistry (43), in addition to reactions that depend on microorganisms (biosynthesis) (49)(50)(51). In this section, we tried to shed light on the most important of these organic reactions that took place without harmful solvents as an approach to green chemistry.…”

Section: Solventless Organic Reaction Techniquesmentioning

confidence: 99%

Solvent-free Organic Reaction Techniques as an Approach for Green Chemistry

Younis

Said²

2023

Journal of the Turkish Chemical Society Section A: Chemistry

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Unfortunately, many toxic solvents are used in chemistry laboratories and in the manufacturing of materials, which poses a serious risk to process safety, the natural environment, and human health. In this review, different tools for solvent-free organic reactions have been surveyed as an approach for green chemistry, where many of the solvents are known to upset our ecosystems so an enormous research effort has been exerted during the last decade to avoid the utilization of hazardous solvents and the number of publications on solvent-free reactions has increased nearly exponentially. Obviously, this reflects the great interest in solventless reactions. In our survey, we will highlight the solvent-free organic reaction as an approach for green chemistry to cover work published up to nearly 2022.

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Section: Solventless Organic Reaction Techniquesmentioning

confidence: 99%

Solvent-free Organic Reaction Techniques as an Approach for Green Chemistry

Younis

Said²

2023

Journal of the Turkish Chemical Society Section A: Chemistry

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“…[119] In the F I G U R E 9 Chemical structures of benzimidazole hybrids 50-57 0.3-4.9 µM, MTT assay) showed potent activity against MCF-7, MDA-MB-231, HeLa, CNE2, HCT-116, and HepG2 cancer cell lines. [120][121][122] In addition, hybrid 56 could significantly suppress the PI3K/Akt/mTOR signaling pathway at 10.0 µM, so this hybrid could act as a useful template to develop novel dual PI3K/mTOR inhibitors.…”

Section: Miscellaneous Benzimidazole Hybridsmentioning

confidence: 99%

Benzimidazole hybrids as anticancer drugs: An updated review on anticancer properties, structure–activity relationship, and mechanisms of action (2019–2021)

Feng

Cheng

et al. 2022

Archiv der Pharmazie

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Cancer, characterized by a deregulation of the cell cycle which mainly results in a progressive loss of cellular differentiation and uncontrolled cellular growth, remains a prominent cause of death across the world. Almost all currently available anticancer agents used in clinical practice have developed multidrug resistance, creating an urgent need to develop novel chemotherapeutics. Benzimidazole derivatives could exert anticancer properties through diverse mechanisms, inclusive of the disruption of microtubule polymerization, the induction of apoptosis, cell cycle (G2/M) arrest, antiangiogenesis, and blockage of glucose transport. Moreover, several benzimidazole-based agents have already been approved for the treatment of cancers. Hence, benzimidazole derivatives are useful scaffolds for the development of novel anticancer agents. In particular, benzimidazole hybrids could exert dual or multiple antiproliferative activities and had the potential to overcome drug resistance, demonstrating the potential of benzimidazole hybrids as potential prototypes for clinical deployment in the control and eradication of cancers. The purpose of the present review article is to provide a comprehensive landscape of benzimidazole hybrids as potential anticancer agents, and the structure-activity relationship as well as mechanisms of action are also discussed to facilitate the further rational design of more effective candidates, covering articles published from 2019 to 2021.

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“…The literature survey revealed that the benzimidazole derivatives have been extensively investigated as potential anticancer agents, and these benzimidazole derivatives exhibit anticancer effects through different mechanisms of action such as intercalating mode of action (DNA binding), nonintercalating mode of action (topoisomerases inhibition), DNA alkylation (DNA cleavage), acting on enzyme antimetabolites [DihydrofolateReductase (DHFR) inhibition], sirtuin inhibition (SIrt1 and SIrt2 inhibition), acting on structural proteins (tubulin protein inhibition), and protein kinase inhibition. − …”

Section: Introductionmentioning

confidence: 99%

Novel 1,2,5-Trisubstituted Benzimidazoles Potentiate Apoptosis by Mitochondrial Dysfunction in Panel of Cancer Cells

et al. 2022

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Synthetic small molecules have been very effective in decimating cancer cells by targeting various aberrantly overexpressed oncogenic proteins. These small molecules target proteins involved in cell cycle regulation, cell division, migration, invasion, angiogenesis, and other regulatory proteins to induce apoptosis in cancer cells. In this study, we have synthesized a novel 1,2,5-trisubstituted benzimidazole chemical library of small molecules and unveiled their anticancer potential against a panel of cancer cell lines such as Jurkat, K-562, MOLT-4, HeLa, HCT116, and MIA PaCa-2 cancer cells. The MTT assay and Trypan blue dye exclusion assay clearly unveiled the cytotoxic effect of methyl 1-benzyl-2-(4-fluoro-3-nitrophenyl)-1H-benzo[d]imidazole-5-carboxylate (TJ08) and its potential to induce apoptosis with effective IC 50 of 1.88 ± 0.51, 1.89 ± 0.55, 2.05 ± 0.72, 2.11 ± 0.62, 3.04 ± 0.8, and 3.82 ± 0.25 μM against Jurkat, K562, MOLT-4, HeLa, HCT116, and MIA PaCa-2 cancer cell lines, respectively. Altered mitochondrial membrane potential was observed in HeLa, HCT116, and Jurkat cells due to TJ08 treatment, which was unveiled by JC10 staining. Induction of early and late apoptosis by TJ08 treatment was also unveiled by apoptotic analysis and immunofluorescence imaging. Cell cycle analysis distribution confirms the accumulation of cells in the S-phase in a dose-dependent manner.

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Design, Synthesis, DFT Studies and Anticancer Activity of Novel Metal Complexes Containing 1,3,5-triazino[1,2-a]benzimidazole Moiety Using Microwave as an Approach for Green Chemistry

Cited by 6 publications

References 0 publications

Solvent-free Organic Reaction Techniques as an Approach for Green Chemistry

Solvent-free Organic Reaction Techniques as an Approach for Green Chemistry

Benzimidazole hybrids as anticancer drugs: An updated review on anticancer properties, structure–activity relationship, and mechanisms of action (2019–2021)

Novel 1,2,5-Trisubstituted Benzimidazoles Potentiate Apoptosis by Mitochondrial Dysfunction in Panel of Cancer Cells

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