2023
DOI: 10.2174/1385272827666230809094204
|View full text |Cite
|
Sign up to set email alerts
|

Design, Synthesis, In silico ADMET Prediction, Molecular Docking, Antimicrobial and Antioxidant Evaluation of Novel Diethyl Pyridinyl Phosphonate Derivatives

Ahmed Hussain Jawhari,
Yousef E. Mukhrish,
Ahmed F. El-Sayed
et al.

Abstract: Introduction: A series of new diethyl 4,6-diarylpyridin-2-yl phosphonate derivatives 3a-f, and 5a,b were synthesized, in good yields, from the reaction of 2-bromo-4,6-diarylpyridines 1a,b with Wittig-Horner reagents 2a-c, and 4 in DMF containing sodium hydride at reflux temperature. Method: The newly synthesized compounds were evaluated for antimicrobial and antioxidant activity. The results demonstrated that compounds 5a and 5b exhibited strong antimicrobial activity against S. aureus, E. faecalis, P. aerug… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

0
0
0

Year Published

2024
2024
2025
2025

Publication Types

Select...
5

Relationship

0
5

Authors

Journals

citations
Cited by 7 publications
references
References 36 publications
0
0
0
Order By: Relevance