Designable Coordination Bonding in Mesopores as a pH-Responsive Release System

Gao, Chuanbo; Zheng, Haoquan; Liu, Xing; Shu, Mouhai; Che, Shunai

doi:10.1021/cm100667u

Cited by 83 publications

(83 citation statements)

References 46 publications

(101 reference statements)

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“…Importantly, such a noncovalent interaction can be easily interfered with in mild acidic condition, which has been widely demonstrated and accepted as the characteristic feature of the tumor environment. [257][258][259][260][261][262][263] Therefore, the release rate was largely Reproduced with permission. [ 243 ] Copyright 2015, Royal Society of Chemistry.…”

Section: Mons For Stimuli-responsive Drug Releasementioning

confidence: 99%

Chemistry of Mesoporous Organosilica in Nanotechnology: Molecularly Organic–Inorganic Hybridization into Frameworks

2016

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Organic-inorganic hybrid materials aiming to combine the individual advantages of organic and inorganic components while overcoming their intrinsic drawbacks have shown great potential for future applications in broad fields. In particular, the integration of functional organic fragments into the framework of mesoporous silica to fabricate mesoporous organosilica materials has attracted great attention in the scientific community for decades. The development of such mesoporous organosilica materials has shifted from bulk materials to nanosized mesoporous organosilica nanoparticles (designated as MONs, in comparison with traditional mesoporous silica nanoparticles (MSNs)) and corresponding applications in nanoscience and nanotechnology. In this comprehensive review, the state-of-art progress of this important hybrid nanomaterial family is summarized, focusing on the structure/composition-performance relationship of MONs of well-defined morphology, nanostructure, and nanoparticulate dimension. The synthetic strategies and the corresponding mechanisms for the design and construction of MONs with varied morphologies, compositions, nanostructures, and functionalities are overviewed initially. Then, the following part specifically concentrates on their broad spectrum of applications in nanotechnology, mainly in nanomedicine, nanocatalysis, and nanofabrication. Finally, some critical issues, presenting challenges and the future development of MONs regarding the rational synthesis and applications in nanotechnology are summarized and discussed. It is highly expected that such a unique molecularly organic-inorganic nanohybrid family will find practical applications in nanotechnology, and promote the advances of this discipline regarding hybrid chemistry and materials.

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Section: Mons For Stimuli-responsive Drug Releasementioning

confidence: 99%

Chemistry of Mesoporous Organosilica in Nanotechnology: Molecularly Organic–Inorganic Hybridization into Frameworks

2016

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“…15,[45][46][47] Figures 4 and 5 show the cumulative amount of DOX released from DOX-loaded NPs. As shown in Figure 4A, ∼70% of DOX was released at pH 7.4 from zein 1 /CMCS 1 NPs into bulk solution within 8 h, while the cumulative release of DOX was ∼90% at pH 4 during the same time period.…”

Section: In Vitro Drug Releasementioning

confidence: 99%

Tailoring stimuli-responsive delivery system driven by metal–ligand coordination bonding

Liang¹,

Zhou²,

He³

et al. 2017

IJN

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In this study, a novel coordination bonding system based on metal–tannic acid (TA) architecture on zein/carboxymethyl chitosan (CMCS) nanoparticles (NPs) was investigated for the pH-responsive drug delivery. CMCS has been reported to coat on zein NPs as delivery vehicles for drugs or nutrients in previous studies. The cleavage of either the “metal–TA” or “NH 2 –metal” coordination bonds resulted in significant release of guest molecules with high stimulus sensitivity, especially in mild acidic conditions. The prepared metal–TA-coated zein/CMCS NPs (zein/CMCS-TA/metal NPs) could maintain particle size in cell culture medium at 37°C, demonstrating good stability compared with zein/CMCS NPs. In vitro release behavior of doxorubicin hydrochloride (DOX)-loaded metal–TA film-coated zein/CMCS NPs (DOX-zein/CMCS-TA/metal NPs) showed fine pH responsiveness tailored by the ratio of zein to CMCS as well as the metal species and feeding concentrations. The blank zein/CMCS-TA/metal NPs (NPs-TA/metal) were of low cytotoxicity, while a high cytotoxic activity of DOX-zein/CMCS-TA/metal NPs (DOX-NPs-TA/metal) against HepG2 cells was demonstrated by in vitro cell assay. Confocal laser scanning microscopy (CLSM) and flow cytometry were combined to study the uptake efficiency of DOX-NPs or DOX-NPs-TA/metal. This system showed significant potential as a highly versatile and potent platform for drug delivery.

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“…Most of these mechanisms rely on external stimuli to trigger the liberation of drugs like the presence of small molecules [135] or enzymes [136], changes in the redox potential [137] or pH [138] and photoirradiation [139]. A key role in the release process play different kinds of capping agents that include organic molecules, gold nanoparticles, polymers, antibodies and DNA.…”

Section: Nps Composed Of Silica and Dnamentioning

confidence: 99%

Drug delivery systems based on nucleic acid nanostructures

Vries

Zhang

Herrmann

2013

Journal of Controlled Release

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a b s t r a c t a r t i c l e i n f oThe field of DNA nanotechnology has progressed rapidly in recent years and hence a large variety of 1D-, 2D-and 3D DNA nanostructures with various sizes, geometries and shapes is readily accessible. DNA-based nanoobjects are fabricated by straight forward design and self-assembly processes allowing the exact positioning of functional moieties and the integration of other materials. At the same time some of these nanosystems are characterized by a low toxicity profile. As a consequence, the use of these architectures in a biomedical context has been explored. In this review the progress and possibilities of pristine nucleic acid nanostructures and DNA hybrid materials for drug delivery will be discussed. For the latter class of structures, a distinction is made between carriers with an inorganic core composed of gold or silica and amphiphilic DNA block copolymers that exhibit a soft hydrophobic interior.

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Designable Coordination Bonding in Mesopores as a pH-Responsive Release System

Cited by 83 publications

References 46 publications

Chemistry of Mesoporous Organosilica in Nanotechnology: Molecularly Organic–Inorganic Hybridization into Frameworks

Chemistry of Mesoporous Organosilica in Nanotechnology: Molecularly Organic–Inorganic Hybridization into Frameworks

Tailoring stimuli-responsive delivery system driven by metal–ligand coordination bonding

Drug delivery systems based on nucleic acid nanostructures

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Designable Coordination Bonding in Mesopores as a pH-Responsive Release System

Cited by 83 publications

References 46 publications

Chemistry of Mesoporous Organosilica in Nanotechnology: Molecularly Organic–Inorganic Hybridization into Frameworks

Chemistry of Mesoporous Organosilica in Nanotechnology: Molecularly Organic–Inorganic Hybridization into Frameworks

Tailoring stimuli-responsive delivery system driven by metal&ndash;ligand coordination bonding

Drug delivery systems based on nucleic acid nanostructures

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Tailoring stimuli-responsive delivery system driven by metal–ligand coordination bonding