2010
DOI: 10.1089/ten.tec.2009.0511
|View full text |Cite
|
Sign up to set email alerts
|

Designed Three-Dimensional Collagen Scaffolds for Skin Tissue Regeneration

Abstract: One of the challenges in tissue engineering is the development of a reproducible three-dimensional (3D) scaffold to support cell migration and infiltration. As a dermal substitute, 3D collagen scaffolds with precisely controlled pore structures were fabricated using an innovative cryogenic dispenser system. The scaffolds were composed of perpendicular, highly porous collagen strands in successive layers. The fabricated scaffolds were evaluated in an in vitro keratinocyte/fibroblast coculture test. Fibroblasts … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1

Citation Types

0
53
0
1

Year Published

2011
2011
2024
2024

Publication Types

Select...
7
3

Relationship

1
9

Authors

Journals

citations
Cited by 78 publications
(54 citation statements)
references
References 23 publications
0
53
0
1
Order By: Relevance
“…The basic components for tissue engineering involve an interactive triad of scaffolds [79][80][81] , signaling molecules [82][83][84] and cells [24,33,41,85] , which play a fundamental role in the regeneration process [24,76,86,87] . Scaffolds serve as a threedimensional template mimicking the extracellular matrix; signaling molecules enhance this cellular activity by stimulating cells to migrate, proliferate and differentiate; and cells provide the machinery synthesis of the extracellular matrix and tissue regeneration [24,75,76,88,89] .…”
Section: Perspectives On Tdscs In Regenerative Approachesmentioning
confidence: 99%
“…The basic components for tissue engineering involve an interactive triad of scaffolds [79][80][81] , signaling molecules [82][83][84] and cells [24,33,41,85] , which play a fundamental role in the regeneration process [24,76,86,87] . Scaffolds serve as a threedimensional template mimicking the extracellular matrix; signaling molecules enhance this cellular activity by stimulating cells to migrate, proliferate and differentiate; and cells provide the machinery synthesis of the extracellular matrix and tissue regeneration [24,75,76,88,89] .…”
Section: Perspectives On Tdscs In Regenerative Approachesmentioning
confidence: 99%
“…6 Three-dimensional (3D) collagen scaffolds seeded with fibroblasts and keratinocytes can generate a stratum corneum similar to that found in human skin. 7 In addition to fabricated tissue, collagen-based matrices have also been increasingly utilized to control the differentiation and orientation of various cell populations in vitro and in vivo. Micro patterned collagen has been used to direct bone formation, manage smooth muscle cell morphology, and to control mesenchymal stem cell attachment.…”
mentioning
confidence: 99%
“…Mientras que los resultados arrojados en esta investigación, muestran que el diámetro de poro promedio de las matrices de 2:8, AH y Col entrecruzadas con 50 mM EDC.HCl se encuentra alrededor de los 50 µm; la bibliografía sugiere que para matrices porosas con aplicaciones en sustitutos de piel, el rango del tamaño de poro ideal debería oscilar entre los 100 µm y 200 µm [20,21]. Por lo tanto, es necesario hacer más pruebas en la fabricación de las matrices con variaciones tanto en la temperatura y tiempo de congelación de la muestra como en los tiempos de liofilización para obtener matrices con un tamaño de poro ideal para este tipo de aplicaciones.…”
Section: Evaluación De Viabilidad Celular Sobre Matrices: Prueba De Mttunclassified