Designer peptides as versatile building blocks for functional materials

Dhawan, Sameer; Singh, Hanuman; Dutta, Souvik; Haridas, V.

doi:10.1016/j.bmcl.2022.128733

Cited by 10 publications

(15 citation statements)

References 182 publications

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“…2) are synthesized using the previously published protocol. 27,49,58 The synthesis of polymers PFH and PEO is presented in Schemes 1 and 2.…”

Section: Synthesis and Characterizationmentioning

confidence: 99%

“…The crude product is purified by silica gel (100-200 mesh) column chromatography using EtOAc : hexane (1 : 9) as eluent to obtain 1.050 g of the pure product A1 (Scheme 1). 27,49,58 Yield: 83%; appearance: white powder; m.p. : 93-95 1C.…”

Section: Synthesis and Characterizationmentioning

confidence: 99%

“…The exo-norbornene dicarboxylic anhydride (0.150 g, 0.91 mmol) is added, and the reaction mixture is refluxed at 60-80 1C for 4-5 h. After evaporating the solvent, the residue is loaded onto silica gel (100-200 mesh) column chromatography, followed by the elution using EtOAc : hexane (3 : 7) to yield 0.220 g of pure EO (Scheme 1). 27,49,58 Yield: 75%; appearance: yellow syrup. is added to quench the polymerization.…”

Section: Synthesis Of Fhmentioning

confidence: 99%

“…The polymer PFH is precipitated out of the reaction mixture by adding methanol and dried under vacuum (Scheme 2). 27,49,58 Yield: quantitative; appearance: light brown film. 2.2.5 Synthesis of PEO.…”

Section: Synthesis Of Fhmentioning

confidence: 99%

“…48 Self-assembling ability is an added feature of amino acid-based bottlebrush polymers. [49][50][51] We recently investigated the impact of bottlebrush polymer molecular weight variation on the performance of light scattering switches and on the modulation of LC matrix characteristics. 27,46 This work aims to design and synthesize amino acid-based bottlebrush polymer matrix with different appendages to establish a controlled LC director configuration in PDLC for sensing applications.…”

Section: Introductionmentioning

confidence: 99%

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Liquid crystal droplet design by using pseudopeptidic bottlebrush polymer additives

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“…2) are synthesized using the previously published protocol. 27,49,58 The synthesis of polymers PFH and PEO is presented in Schemes 1 and 2.…”

Section: Synthesis and Characterizationmentioning

confidence: 99%

Section: Synthesis and Characterizationmentioning

confidence: 99%

Section: Synthesis Of Fhmentioning

confidence: 99%

Section: Synthesis Of Fhmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Liquid crystal droplet design by using pseudopeptidic bottlebrush polymer additives

et al. 2022

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Short Peptide Nanofiber Biomaterials Ameliorate Local Hemostatic Capacity of Surgical Materials and Intraoperative Hemostatic Applications in Clinics

et al. 2023

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Short designer self‐assembling peptide (dSAP) biomaterials are a new addition to the hemostat group. It may provide a diverse and robust toolbox for surgeons to integrate wound microenvironment with much safer and stronger hemostatic capacity than conventional materials and hemostatic agents. Especially in noncompressible torso hemorrhage (NCTH), diffuse mucosal surface bleeding, and internal medical bleeding (IMB), with respect to the optimal hemostatic formulation, dSAP biomaterials are the ingenious nanofiber alternatives to make bioactive neural scaffold, nasal packing, large mucosal surface coverage in gastrointestinal surgery (esophagus, gastric lesion, duodenum, and lower digestive tract), epicardiac cell‐delivery carrier, transparent matrix barrier, and so on. Herein, in multiple surgical specialties, dSAP‐biomaterial‐based nano‐hemostats achieve safe, effective, and immediate hemostasis, facile wound healing, and potentially reduce the risks in delayed bleeding, rebleeding, post‐operative bleeding, or related complications. The biosafety in vivo, bleeding indications, tissue‐sealing quality, surgical feasibility, and local usability are addressed comprehensively and sequentially and pursued to develop useful surgical techniques with better hemostatic performance. Here, the state of the art and all‐round advancements of nano‐hemostatic approaches in surgery are provided. Relevant critical insights will inspire exciting investigations on peptide nanotechnology, next‐generation biomaterials, and better promising prospects in clinics.

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Bispidine as a Versatile Scaffold: From Topological Hosts to Transmembrane Transporters

Singh,

Khatoon,

Bhardwaj

et al. 2023

ChemBioChem

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The development of designer topological structures is synthetically challenging endeavor. We herein present bispidine as a platform for the design of molecules with various topologies and functions. Bispidine‐based acyclic molecule, showing intriguing S‐shape topology was discussed. Single crystal X‐ray revealed that this molecule exists in solid state as two conformational enantiomers. In addition to that, bispidine‐based designer macrocycles were synthesized and investigated for ionophoric properties. Patch clamp experiments revealed that these macrocycles transport non‐specifically both anions and cations with at least 10‐fold higher chloride conductance over the cations under the given experimental conditions. The results indicated that the self‐assembling macrocycle form tubular assembly as evident from ultramicroscopic techniques and single crystal X‐ray crystallographic studies. Our design highlights the utilization of non‐conventional dihydrogen interactions in nanotube fabrication.

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Designer peptides as versatile building blocks for functional materials

Cited by 10 publications

References 182 publications

Liquid crystal droplet design by using pseudopeptidic bottlebrush polymer additives

Liquid crystal droplet design by using pseudopeptidic bottlebrush polymer additives

Short Peptide Nanofiber Biomaterials Ameliorate Local Hemostatic Capacity of Surgical Materials and Intraoperative Hemostatic Applications in Clinics

Bispidine as a Versatile Scaffold: From Topological Hosts to Transmembrane Transporters

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