Designing a green poly(β-amino ester) for the delivery of nicotinamide drugs with biological activities and conducting a DFT investigation

Hashem, M. S.; Fahim, Asmaa M.; Helaly, F. M.

doi:10.1039/d3ra08585f

RSC Adv.

2024

DOI: 10.1039/d3ra08585f

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Designing a green poly(β-amino ester) for the delivery of nicotinamide drugs with biological activities and conducting a DFT investigation

M. S. Hashem,

Asmaa M. Fahim,

F. M. Helaly

Abstract: Poly(β-amino ester) was synthesized through addition polymerization under microwave irradiation, demonstrating antimicrobial and anticancer activities against MCF-7 tumor cells, along with an impressive ability to prevent drug leakage.

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Cited by 7 publications

References 64 publications

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Fabrication and Evaluation of Polyacrylate Nanocomposites Embedded With Metal Oxides as Enhanced Multipurpose Nanocarriers for Long‐Term Anti‐Inflammatory and Amazing Antimicrobial Properties

Sobh,

Magar,

Fahim

et al. 2024

Applied Organom Chemis

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The design of super‐antimicrobially active multipurpose nanocarriers as polymeric nanocomposites embedded with metal oxides with sustained drug release is beneficial in medical treatment for controlling inflammation and targeting a wide range of pathogenic microorganisms. Brilliant metal oxide nanoparticles (MOx) involving selenium dioxide, titanium dioxide, and vanadium pentoxide were well prepared in good yields, and their morphologies and structures were specified. Then they were embedded in copolymeric nanocomposites through in situ microemulsion polymerization of (E)‐2‐cyano‐N‐cyclohexyl‐3‐(dimethylamino)acrylamide (CHAA) with methyl methacrylate (MMA), dimethylaminoethyl methacrylate (DMAEMA), and acrylic acid (AA). In addition, ibuprofen was then loaded into the synthesized polymers and their nanocomposites to achieve high drug entrapment efficiency EE%, and its release behavior was studied in various simulated fluids. The produced drug‐loaded polymers and their nanocomposites were characterized using Fourier‐transform infrared spectroscopy (FT‐IR), transmission electron microscope (TEM), X‐ray diffraction (XRD), and thermogravimetric analysis (TG). Well‐defined nanospheres of polymeric‐metal oxide nanocomposites were generated in a size range of 50 nm, with ibuprofen loaded at a high encapsulation efficiency of approximately 97%. In vitro drug release was inspected for the polymer and its nanocomposites revealing that the presence of metal oxide nanoparticles resulted in prolonged and sustained release behavior for wound dressing. The antimicrobial study based on the zone of inhibition against various pathogenic microorganisms showed excellent activity against Bacillus cereus, Staphylococcus aureus, Escherichia coli, Helicobacter pylori, and Candida albicans. These findings validate the potential of these nanocomposites to serve as a viable upcoming antimicrobial agent for the treatment of human ailments.

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Fabrication and Evaluation of Polyacrylate Nanocomposites Embedded With Metal Oxides as Enhanced Multipurpose Nanocarriers for Long‐Term Anti‐Inflammatory and Amazing Antimicrobial Properties

Sobh,

Magar,

Fahim

et al. 2024

Applied Organom Chemis

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pH‐responsive bionanocomposite pectin grafted with dimethylaminoethyl methacrylate and acrylic acid copolymer along with silver nanoparticles for breast cancer drug delivery

Hashem,

Sobh,

Abd El‐Ghaffar

2024

Polymer Engineering & Sci

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In this study, we developed a pH‐responsive hydrogel membrane composed of pectin, dimethylaminoethyl methacrylate (DMAEMA), and acrylic acid (AA) through a free radical‐triggered graft copolymerization method. Freshly formed silver nanoparticles (AgNPs) produced from the reduction reaction were embedded in the produced hydrogel. Pectin‐grafted dimethylaminoethyl methacrylate and acrylic acid copolymer [poly (DMAEMA‐co‐AA)‐g‐pectin] and its bionanocomposite with AgNPs were confirmed by Fourier‐transform infrared spectroscopy (FT‐IR), scanning electron microscopy (SEM), and thermogravimetric analysis (TGA). The swelling behavior of poly (DMAEMA‐co‐AA)‐g‐pectin in solutions with diverse pH values was assessed. For use as a controlled drug delivery agent, the hydrogel was loaded with 5‐fluorouracil (5‐FU). The incorporation of AgNPs had a great impact on the entrapment efficiency of 5‐FU. At pH 7.4, nearly 48% of the 5‐FU was released in vitro from the polymeric nanocomposite within 24 h. Moreover, poly (DMAEMA‐co‐AA)‐g‐pectin and poly (DMAEMA‐co‐AA)‐g‐pectin/AgNPs presented high cytocompatibility toward normal skin fibroblast cells (BJ1), and the drug delivery system strongly inhibited human Caucasian breast adenocarcinoma cells (MCF‐7). These results demonstrated that these poly (DMAEMA‐co‐AA)‐g‐pectin/AgNPs are an excellent candidate for use in anticancer drug delivery systems.Highlights Free radical polymerization of nanocomposites incorporated with nanoparticles. Nanoparticles improve the bionanocomposites' drug loading. The developed bionanocomposites exhibit control drug release. The novel bionanocomposites acts as an excellent anticancer drug carrier.

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Antimicrobial, anticancer activities, molecular docking, and DFT/B3LYP/LANL2DZ analysis of heterocyclic cellulose derivative and their Cu-complexes

Fahim,

Dacrory,

Hashem

et al. 2024

International Journal of Biological Macromolecules

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Designing a green poly(β-amino ester) for the delivery of nicotinamide drugs with biological activities and conducting a DFT investigation

Abstract: Poly(β-amino ester) was synthesized through addition polymerization under microwave irradiation, demonstrating antimicrobial and anticancer activities against MCF-7 tumor cells, along with an impressive ability to prevent drug leakage.

Cited by 7 publications

References 64 publications

Fabrication and Evaluation of Polyacrylate Nanocomposites Embedded With Metal Oxides as Enhanced Multipurpose Nanocarriers for Long‐Term Anti‐Inflammatory and Amazing Antimicrobial Properties

Fabrication and Evaluation of Polyacrylate Nanocomposites Embedded With Metal Oxides as Enhanced Multipurpose Nanocarriers for Long‐Term Anti‐Inflammatory and Amazing Antimicrobial Properties

pH‐responsive bionanocomposite pectin grafted with dimethylaminoethyl methacrylate and acrylic acid copolymer along with silver nanoparticles for breast cancer drug delivery

Antimicrobial, anticancer activities, molecular docking, and DFT/B3LYP/LANL2DZ analysis of heterocyclic cellulose derivative and their Cu-complexes

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