Designing a highly stable coordination-driven metallacycle for imaging-guided photodynamic cancer theranostics

He, Lizhen; Cai, Li‐Xuan; Li, Menghua; Zhang, Guang-Lu; Zhou, Lixin; Chen, Tianfeng; Lin, Mei‐Jin; Sun, Qing‐Fu

doi:10.1039/d0sc02236e

Cited by 27 publications

(16 citation statements)

References 62 publications

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“…21 Considering the aromatic PDI core, it has been shown that bay substitution with sulfones lead to low-lying LUMO levels on naphthalene diimide (NDI) analogues that are stable, notably in presence of water. 22 Here, we have designed two new ligands, derived from the chlorinated parent PDI-Cl 4 23 (Fig. 1), and bearing bay substituted sulfones with either open n-alkyl chain (PDI-SO 2 7) or closed ethylene bridges (PDI-SO 2 eth 10).…”

mentioning

confidence: 99%

New sulfonated perylene diimide pyrazolate ligands: a simple route toward n-type redox-active hybrid materials

Monnier¹,

Odobel

Diring

2022

Chem. Commun.

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confidence: 99%

New sulfonated perylene diimide pyrazolate ligands: a simple route toward n-type redox-active hybrid materials

Monnier¹,

Odobel

Diring

2022

Chem. Commun.

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“…Therefore, the hydrolytic activity of Ir2 and Ir4 in DMSO/H 2 O solution (1:4, v/v) was researched by UV–vis absorption spectra (Figure S7a,b). The presence of a small amount of DMSO ensures the dissolution of complexes, and the stability in which was verified by 1 H NMR (Figure S8). As shown, compared with Ir2 , UV–vis spectra of Ir4 show hardly any change over time, which validates the stability of aqueous solution.…”

Section: Results and Discussionmentioning

confidence: 85%

In Vitro and In Vivo of Triphenylamine-Appended Fluorescent Half-Sandwich Iridium(III) Thiosemicarbazones Antitumor Complexes

et al. 2021

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Half-sandwiched structure iridium(III) complexes appear to be an attractive organometallic antitumor agents in recent years. Here, four triphenylamine-modified fluorescent half-sandwich iridium(III) thiosemicarbazone (TSC) antitumor complexes were developed. Because of the “enol” configuration of the TSC ligands, these complexes formed a unique dimeric configuration. Aided by the appropriate fluorescence properties, studies found that complexes could enter tumor cells in an energy-dependent mode, accumulate in lysosomes, and result in the damage of lysosome integrity. Complexes could block the cell cycle, improve the levels of intrastitial reactive oxygen species, and lead to apoptosis, which followed an antitumor mechanism of oxidation. Compared with cisplatin, the antitumor potential in vivo and vitro confirmed that Ir4 could effectively inhibit tumor growth. Meanwhile, Ir4 could avoid detectable side effects in the experiments of safety evaluation. Above all, half-sandwich iridium(III) TSC complexes are expected to be an encouraging candidate for the treatment of malignant tumors.

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“…To date, a number of remarkable achievements have been reported for coordination‐driven self‐assembly, from accurate assemblies of various Pt metallacycles [ 100,102–104,150 ] and metallacages [ 104c,151 ] to multiple applications of these self‐assemblies, including cell imaging, [ 152 ] optoelectronics, drug delivery, [ 104c ] and controlled release [ 108 ] for cancer theranostic. Specifically, because of the different organic ligands and Pt‐based acceptors, the shape of the two‐dimensional Pt(II) metallacycles can be diverse, such as triangle, [ 102 ] hexagon, [ 153 ] rectangle, [ 154 ] rhomboidal, [ 104b,155 ] and other polygons.…”

Section: Metal‐coordinated Supramolecular Self‐assemblies For Cancer Theranosticsmentioning

confidence: 99%

Metal‐Coordinated Supramolecular Self‐Assemblies for Cancer Theranostics

Wang

Jin

et al. 2021

Advanced Science

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Metal‐coordinated supramolecular nanoassemblies have recently attracted extensive attention as materials for cancer theranostics. Owing to their unique physicochemical properties, metal‐coordinated supramolecular self‐assemblies can bridge the boundary between traditional inorganic and organic materials. By tailoring the structural components of the metal ions and binding ligands, numerous multifunctional theranostic nanomedicines can be constructed. Metal‐coordinated supramolecular nanoassemblies can modulate the tumor microenvironment (TME), thus facilitating the development of TME‐responsive nanomedicines. More importantly, TME‐responsive organic–inorganic hybrid nanomaterials can be constructed in vivo by exploiting the metal‐coordinated self‐assembly of a variety of functional ligands, which is a promising strategy for enhancing the tumor accumulation of theranostic molecules. In this review, recent advancements in the design and fabrication of metal‐coordinated supramolecular nanomedicines for cancer theranostics are highlighted. These supramolecular compounds are classified according to the order in which the coordinated metal ions appear in the periodic table. Furthermore, the prospects and challenges of metal‐coordinated supramolecular self‐assemblies for both technical advances and clinical translation are discussed. In particular, the superiority of TME‐responsive nanomedicines for in vivo coordinated self‐assembly is elaborated, with an emphasis on strategies that enhance the accumulation of functional components in tumors for an ideal theranostic outcome.

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Designing a highly stable coordination-driven metallacycle for imaging-guided photodynamic cancer theranostics

Abstract: A highly-luminescent metallacycle with chemical stability and singlet oxygen production ability were obtained by a spontaneous deprotonation self-assembly process, which exhibits application potential in imaging-guided photodynamic cancer therapy.

Cited by 27 publications

References 62 publications

New sulfonated perylene diimide pyrazolate ligands: a simple route toward n-type redox-active hybrid materials

New sulfonated perylene diimide pyrazolate ligands: a simple route toward n-type redox-active hybrid materials

In Vitro and In Vivo of Triphenylamine-Appended Fluorescent Half-Sandwich Iridium(III) Thiosemicarbazones Antitumor Complexes

Metal‐Coordinated Supramolecular Self‐Assemblies for Cancer Theranostics

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