Designing a novel and versatile multi-layered nanofibrous structure loaded with MTX and 5-FU for the targeted delivery of anticancer drugs

Poursharifi, Nazanin; Semnani, Dariush; Soltani, Parham; Amanpour, Saeid

doi:10.1016/j.polymdegradstab.2020.109275

Cited by 20 publications

(9 citation statements)

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“…Pluronic ® polymers were self-assembled into Pluronic micelles with a hydrophilic PEO segment at the corona and a hydrophobic PPO segment in the core. Studies elucidated that 5-FU would be hydrophilic [ 20 , 21 , 22 , 23 , 24 ] or hydrophobic molecules [ 25 , 26 , 27 , 28 ]. However, for drug release, the encapsulation of the drug in micelles was highly dependent on its loading location rather than the intrinsic solubility of the drug in aqueous solution.…”

Section: Resultsmentioning

confidence: 99%

Thermosensitive Interfacial Migration of 5-FU in the Microenvironment of Pluronic Block Copolymers

Lin

Yeh

2021

Polymers

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Chemotherapy is one of the most important ways to treat cancer. At present, chemotherapy medicines are mainly administered by intravenous injection or oral administration. However, systemic medical care requires the dosage of high concentrations of drugs to defeat the malignant tumor growth. In recent years, the use of polymer composites for local and sustained drug release has become an important field of research to minimize side effects due to high-concentration chemotherapy drugs. Here, 19F-{1H} heteronuclear Overhauser enhancement spectroscopy (HOESY) was used to study the micellular environment of the F-containing chemotherapeutic drug 5-FU in Pluronic F127, Pluronic L121, and F127/L121 binary blending composites. The distribution of 5-FU in micelles is related to the PEO and PPO segment length of Pluronic polymers and the environmental temperature. The drug release tests further confirm that if 5-FU medicines were loaded in the PPO segment inside the micelles, the purpose of the prolonged drug release carrier is achieved.

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Section: Resultsmentioning

confidence: 99%

Thermosensitive Interfacial Migration of 5-FU in the Microenvironment of Pluronic Block Copolymers

Lin

Yeh

2021

Polymers

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“…The surface topography of all the fabricated nanofiber mats is illustrated in Figure . The surface of pristine NF showed uniform drug distribution and a smooth and continuous nanofiber shape . But NF1 nanofiber mats exhibit uneven and rough surface morphology with lesser average fiber diameter compared to pristine NF.…”

Section: Resultsmentioning

confidence: 96%

“…Even though complete drug loading was achieved, the entrapped drug release was 74.56% only, which is due to the hydrophobicity of PCL, hydrogen bonding, and also the high thickness of the nanofiber mat compared to the other mats. 34 The NF1 mat showed 38 and 47.79% drug release in the 5th day and 19th day, respectively, and then reached equilibrium. Compared to pristine NF, MgO holds the drug strongly and releases in a controlled manner, which is due to the coordinate interaction between MgO and 5Fu.…”

Section: Differential Scanning Calorimetric Analysismentioning

confidence: 91%

“…The surface of pristine NF showed uniform drug distribution and a smooth and continuous nanofiber shape. 34 But NF1 nanofiber mats exhibit uneven and rough surface morphology with lesser average fiber diameter compared to pristine NF. The reason behind this is the incorporation of MgO nanoparticles, which provided increased electrical conductivity.…”

Section: X-ray Diffraction Studiesmentioning

confidence: 98%

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A Study on the Effect of Nanoscale MgO and Hydrogen Bonding in Nanofiber Mats for the Controlled Drug Release along with In Vitro Breast Cancer Cell Line and Antimicrobial Studies

Jaisankar¹,

Azarudeen²,

Thirumarimurugan³

2022

ACS Appl. Bio Mater.

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Nanosized metal oxide-incorporated drug carriers have received significant attention due to their biocompatibility, mechanical strength, controlled drug release, and biodegradability. Herein, an attempt was made to fabricate polycaprolactone-based electrospun nanofiber mats involving the 5-fluorouracil (5Fu) drug, MgO nanoparticle, methyl cellulose, and polyethylene glycol. The chemical interactions, surface wettability, mechanical properties, structural and morphological changes, and thermal stability were studied by the respective analyses. The ionic interaction between 5Fu, MgO, and polymers were found to be responsible for the controlled drug release. Zero-order kinetic and model data also revealed that a controlled drug release pattern was observed in a period of 16 days. Furthermore, the nanofiber mats were subjected to cytotoxicity studies against MDA-MB-231 cancer cell line and the results showed higher cytotoxicity in a short time of 24 h and less toxicity to normal L929 fibroblast cell line. The apoptosis in cancer cell lines was also tested by AO/PI staining assay and confirmed by fluorescence microscopy. In addition, the growth inhibition of several bacterial and fungal strains was tested for the mats and the results exhibited good inhibition activity. Hence, the reported nanofiber drug carrier was found to be an efficient implant for the controlled release of anticancer drug along with other significant properties.

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“…Nanofibers are currently one of the most popular polymer structures with various applications, mainly due to the large surface‐to‐volume ratio and high porosity 1 . Many applications have been reported for this structure in areas such as composite fabrication, 2 filtration, 3 sensors and actuators, 4,5 lithium‐ion batteries, 6 drug delivery 7–9 and tissue engineering 10–12 . The nanofibers are produced employing various techniques, among which the electrospinning method is of special importance due to the simplicity and the convenient engineering.…”

Section: Introductionmentioning

confidence: 99%

Electro‐conductive nanofibrous structure based on PGS/PCL coated with PPy by in situ chemical polymerization applicable as cardiac patch: Fabrication and optimization

Fakhrali

Semnani

Salehi

et al. 2022

J of Applied Polymer Sci

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As a special structure and due to the unique properties of submicron-scale fibers and electrical conductivity, conductive nanofibers recently attracted further attention in various fields, especially tissue engineering. This study aimed to coat poly (glycerol sebacate) (PGS) nanofiber/poly(caprolactone) (PCL) as a widely used combination in the fields of medicine with poly(pyrrole) (PPy) as a conductive polymer, subsequently studying and optimizing production process variables using response surface methodology (RSM). The samples were examined for morphological and structural, and their electrical conductivity and electroactivity were measured using a fourpoint probe system and a cyclic voltammetry, respectively. The electrospinning conditions for constructing the substrate nanofibers with the smallest diameter were optimized. The monomer concentration of 0.05M and the polymerization time of 3.3 h exploiting the RSM were also considered as the optimal conditions for obtaining coated-nanofibers with the smallest diameter and desired electrical conductivity (0.001 S/cm). The structural findings confirmed the successful synthesis of PGS and PPy. The conductive-nanofiber produced under optimal conditions revealed good mechanical properties (tensile strength = 3.12 ± 0.19 MPa and elongation at break = 80.26 ± 13.71%). The highest biocompatibility was observed for the sample synthesized with the pyrrole concentration of 0.05M, which can be a suitable candidate for application in cardiac tissue engineering.

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Designing a novel and versatile multi-layered nanofibrous structure loaded with MTX and 5-FU for the targeted delivery of anticancer drugs

Cited by 20 publications

References 50 publications

Thermosensitive Interfacial Migration of 5-FU in the Microenvironment of Pluronic Block Copolymers

Thermosensitive Interfacial Migration of 5-FU in the Microenvironment of Pluronic Block Copolymers

A Study on the Effect of Nanoscale MgO and Hydrogen Bonding in Nanofiber Mats for the Controlled Drug Release along with In Vitro Breast Cancer Cell Line and Antimicrobial Studies

Electro‐conductive nanofibrous structure based on PGS/PCL coated with PPy by in situ chemical polymerization applicable as cardiac patch: Fabrication and optimization

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