Designing a simple organic salt-based supramolecular topical gel capable of displaying in vivo self-delivery application

Majumder, Joydeb; Deb, Jolly; Das, Madhusweta; Jana, Siddhartha S.; Dastidar, Parthasarathi

doi:10.1039/c3cc48513g

Cited by 64 publications

(50 citation statements)

References 27 publications

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“…Organogels based on pharmaceutically relevant oils can be used for API formulation, 7 for example Naproxen salts form organogels capable of controlled API release. 8 However, hydrogels offer potentially greater biocompatibility. Many studies have focussed on peptide derived gels.…”

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confidence: 99%

Self-assembled sorbitol-derived supramolecular hydrogels for the controlled encapsulation and release of active pharmaceutical ingredients

2015

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confidence: 99%

Self-assembled sorbitol-derived supramolecular hydrogels for the controlled encapsulation and release of active pharmaceutical ingredients

2015

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“…This three-component system displayed superior in vitro anticancer activity when compared to each drug alone, suggesting a synergetic effect of the two drugs, though only at low 5-FU concentrations as higher concentrations resulted in an antagonistic effect that is known for this drug combination [175]. In a final example, Jana and Dastidar developed a xerogel platform in which naproxen and its β-alanine derivatives were induced to form gels by the addition of the biocompatible amine, serinol [176]. The resulting salt could form an extended hydrogen bonding network, giving nanofibers that could entangle to form gels with weak to moderate mechanical properties.…”

Section: Supramolecular Hydrogels Formed By Amphiphilic Prodrugsmentioning

confidence: 99%

Building nanostructures with drugs

2016

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The convergence of nanoscience and drug delivery has prompted the formation of the field of nanomedicine, one that exploits the novel physicochemical and biological properties of nanostructures for improved medical treatments and reduced side effects. Until recently, this nanostructure-mediated strategy considered the drug to be solely a biologically active compound to be delivered, and its potential as a molecular building unit remained largely unexplored. A growing trend within nanomedicine has been the use of drug molecules to build well-defined nanostructures of various sizes and shapes. This strategy allows for the creation of self-delivering supramolecular nanomedicines containing a high and fixed drug content. Through rational design of the number and type of the drug incorporated, the resulting nanostructures can be tailored to assume various morphologies (e.g. nanospheres, rods, nanofibers, or nanotubes) for a particular mode of administration such as systemic, topical, and local delivery. This review covers the recent advances in this rapidly developing field, with the aim of providing an in-depth evaluation of the exciting opportunities that this new field could create to improve the current clinical practice of nanomedicine.

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“…[56] Among these, the primary ammonium monocarboxylate (PAM) synthoni sp articularly important (Scheme 1). [72][73][74] The anti-inflammatory activity of an onsteroidal anti-inflammatoryd rug (NSAID) is known to follow the cyclooxygenase( COX) pathway by acting as an inhibitor of COX enzymes, thereby reducing the intracellularc oncentration of prostaglandin E 2 (PGE 2 ), the consequenceo fw hich is ar eduction of inflammation of cells. [58,59] Recently, we launched an initiativet od evelop drug-delivery systems that would act in as elf-delivery manner.…”

Section: Introductionmentioning

confidence: 99%

Rationally Developed Organic Salts of Tolfenamic Acid and Its β‐Alanine Derivatives for Dual Purposes as an Anti‐Inflammatory Topical Gel and Anticancer Agent

Parveen

Sravanthi

Dastidar

2017

Chemistry An Asian Journal

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A new series of primary ammonium monocarboxylate (PAM) salts of a nonsteroidal anti-inflammatory drug (NSAID), namely, tolfenamic acid (TA), and its β-alanine derivatives were generated. Nearly 67 % of the salts in the series showed gelling abilities with various solvents, including water (biogenic solvent) and methyl salicylate (typically used for topical gel formulations). Gels were characterized by rheology, electron microscopy, and so forth. Structure-property correlations based on single-crystal and powder XRD data of several gelator and nongelator salts revealed intriguing insights. Studies (in vitro) on an aggressive human breast cancer cell line (MDA-MB-231) with the l-tyrosine methyl ester salt of TA (S7) revealed that the hydrogelator salt was more effective at killing cancer cells than the mother drug TA (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay); displayed better anti-inflammatory activity compared with that of TA (prostaglandin E assay); could be internalized within the cancer cells, as revealed by fluorescence microscopy; and inhibited effectively migration of the cancer cells. Thus, the easily accessible ambidextrous gelator salt S7 can be used for two purposes: as an anti-inflammatory topical gel and as an anticancer agent.

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Designing a simple organic salt-based supramolecular topical gel capable of displaying in vivo self-delivery application

Cited by 64 publications

References 27 publications

Self-assembled sorbitol-derived supramolecular hydrogels for the controlled encapsulation and release of active pharmaceutical ingredients

Self-assembled sorbitol-derived supramolecular hydrogels for the controlled encapsulation and release of active pharmaceutical ingredients

Building nanostructures with drugs

Rationally Developed Organic Salts of Tolfenamic Acid and Its β‐Alanine Derivatives for Dual Purposes as an Anti‐Inflammatory Topical Gel and Anticancer Agent

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