2016
DOI: 10.1007/s40778-016-0041-9
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Designing Biopolymer Microthreads for Tissue Engineering and Regenerative Medicine

Abstract: Native tissue structures possess elaborate extracellular matrix (ECM) architectures that inspire the design of fibrous structures in the field of regenerative medicine. We review the literature with respect to the successes and failures, as well as the future promise of biopolymer microthreads as scaffolds to promote endogenous and exogenous tissue regeneration. Biomimetic microthread tissue constructs have been proposed for the functional regeneration of tendon, ligament, skeletal muscle, and ventricular myoc… Show more

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Cited by 17 publications
(18 citation statements)
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“…Many strategies have been explored to create scaffolds with anisotropic surface topography, including patterned substrates [154][155][156][157][158][159][160][161]. electrospun fibers [122,123,155,[162][163][164][165], microthreads [166][167][168], and aligned pores [169][170][171]. A review describes these methods in detail and their ability to align and differentiate myoblasts in vitro, as this falls outside of the scope of this review [172].…”
Section: Aligned Scaffoldsmentioning
confidence: 99%
“…Many strategies have been explored to create scaffolds with anisotropic surface topography, including patterned substrates [154][155][156][157][158][159][160][161]. electrospun fibers [122,123,155,[162][163][164][165], microthreads [166][167][168], and aligned pores [169][170][171]. A review describes these methods in detail and their ability to align and differentiate myoblasts in vitro, as this falls outside of the scope of this review [172].…”
Section: Aligned Scaffoldsmentioning
confidence: 99%
“…14,15 Their structure is analogous to native ECM fibrils, and they can be similarly arranged to create hierarchically complex scaffolds to recapitulate a variety of tissue architectures. 16 Microfiber scaffolds also provide provisional structural and mechanical support, topographic cues, and biochemical signaling cues to direct cell-mediated tissue regeneration. 16 Fibrin microthreads are a microfiber scaffold whose cylindrical form mimics native ECM fibrils, promoting cellular alignment and guided tissue regeneration.…”
Section: Introductionmentioning
confidence: 99%
“…16 Microfiber scaffolds also provide provisional structural and mechanical support, topographic cues, and biochemical signaling cues to direct cell-mediated tissue regeneration. 16 Fibrin microthreads are a microfiber scaffold whose cylindrical form mimics native ECM fibrils, promoting cellular alignment and guided tissue regeneration. 3,4,6,7,[17][18][19][20] Fibrin, the bioactive provisional matrix protein responsible for blood clotting, recruits cells that direct wound healing and functional tissue regeneration, making it a beneficial scaffold material.…”
Section: Introductionmentioning
confidence: 99%
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“…3 The interactions between cells and ECM motifs are highly important in determining cell fate and maintaining cellular phenotyp. 4 In order to induce formation of the correct tissue at a specific site, the structure, composition, and source of ECM used must be considere. 5 The macrostructure of ECM can be modified to suit the intended application.…”
Section: Introductionmentioning
confidence: 99%