Designing Drug Regimens that Mitigate Nonadherence

A mathematical model of reward-mediated learning in drug addiction

“…An ideal protocol would calibrate doses and timing to alleviate the negative response as much as possible, but would also prevent the induction of methadone-associated b-processes, or other interactions with addictive pathways. One can also explore the consequences of irregular methadone intakes or nonadherence to specific detoxification protocols 59 .…”