Designing electrospun shellac nanofibers with mupirocin using the Box-Behnken approach for topical wound care

Chinatangkul, Nawinda; Pengon, Sirikarn; Krongrawa, Wantanwa; Chansatidkosol, Siraprapa; Limmatvapirat, Chutima; Limmatvapirat, Sontaya

doi:10.1016/j.jddst.2022.103720

Cited by 5 publications

(4 citation statements)

References 14 publications

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“…However, the release of active compounds might well be altered regardless of the type of polymer used to fabricate electrospun fibers. Due to the mechanical properties, controlled degradation rate, and biological compatibility of shellac, a natural polymer derived from the excretions of the lac Kerria lacca insect, electrospun fibers seemed to become widely attractive [ 13 , 14 , 15 , 16 , 17 ]. Shellac resin contains derivatives of jalaric and laccijalaric acids ( Figure 2 ), and a detailed analysis of the compounds in shellac was recently revealed by flow injection and liquid chromatography coupled with electrospray ionization and mass spectrometry [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

Fabrication, Optimization, and Characterization of Antibacterial Electrospun Shellac Fibers Loaded with Kaempferia parviflora Extract

et al. 2022

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This study aimed to develop a Kaempferia parviflora (KP) extract based on electrospun shellac fibers capable of transporting methoxyflavones. This study used a Box–Behnken design to determine the optimal production parameters that influence the fiber diameter and bead-to-fiber ratio responses. The optimization step produced fibers with a small diameter (574 nm) and a lower bead-to-fiber ratio (0.48 beads per fiber) by combining 37.25% w/w shellac and 1.50% w/w KP extract with a solution feed rate of 0.8 mL/h and an electrical voltage of 18 kV. The KP extract was found to be dispersed throughout the electrospun shellac fibers during the characterization study. The results were highly correlated with the theoretical values, indicating that the regression models used to predict the response variables were adequate. A study of in vitro dissolution confirmed that KP extract-loaded electrospun shellac fibers could produce a sustained-release profile within 10 h. Additionally, KP-infused shellac fibers demonstrated antibacterial activity against Staphylococcus aureus. This KP loading method combined with shellac properties provided a new delivery system and could be used to explore novel biomedical materials.

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Section: Introductionmentioning

confidence: 99%

Fabrication, Optimization, and Characterization of Antibacterial Electrospun Shellac Fibers Loaded with Kaempferia parviflora Extract

et al. 2022

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“…Because of the mechanical characteristics, controlled biodegradation, and biological compatibility of shellac, electrospun fibers made from shellac, a natural polymer derived from the insect Kerria lacca ’s secretion, appear to be gaining widespread popularity [ 126 , 127 , 128 , 129 , 130 , 131 , 132 ]. Consequently, this article explores the creation of bioactive shellac electrospun fibers.…”

Section: Electrospinningmentioning

confidence: 99%

Advances in Natural Product Extraction Techniques, Electrospun Fiber Fabrication, and the Integration of Experimental Design: A Comprehensive Review

et al. 2023

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The present review explores the growing interest in the techniques employed for extracting natural products. It emphasizes the limitations of conventional extraction methods and introduces superior non-conventional alternatives, particularly ultrasound-assisted extraction. Characterization and quantification of bioactive constituents through chromatography coupled with spectroscopy are recommended, while the importance of method development and validation for biomarker quantification is underscored. At present, electrospun fibers provide a versatile platform for incorporating bioactive extracts and have extensive potential in diverse fields due to their unique structural and functional characteristics. Thus, the review also highlights the fabrication of electrospun fibers containing bioactive extracts. The preparation of biologically active extracts under optimal conditions, including the selection of safe solvents and cost-effective equipment, holds promising potential in the pharmaceutical, food, and cosmetic industries. Integration of experimental design into extraction procedures and formulation development is essential for the efficient production of health products. The review explores potential applications of encapsulating natural product extracts in electrospun fibers, such as wound healing, antibacterial activity, and antioxidant properties, while acknowledging the need for further exploration and optimization in this field. The findings discussed in this review are anticipated to serve as a valuable resource for the processing industry, enabling the utilization of affordable and environmentally friendly, natural, and raw materials.

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“…UV treatment is a widely used sterilization technique for medical devices including wound care products. [57,58] Unfortunately, UV exposure denatures enzymes (here lactate oxidase), which results in a decrease in sensor sensitivity. Covering the sensor with widely used UV protective films or absorbers could resolve this issue.…”

Section: Uv Sterilizable Self-powered Oxygen-independent Biofuel Cell...mentioning

confidence: 99%

A Miniaturized, Battery‐Free, Wireless Wound Monitor That Predicts Wound Closure Rate Early

Garland,

Song,

et al. 2023

Adv Healthcare Materials

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Diabetic foot ulcers are chronic wounds that affect millions and increase the risk of amputation and mortality, highlighting the critical need for their early detection. Recent demonstrations of wearable sensors enable real‐time wound assessment, but they rely on bulky electronics, making them difficult to interface with wounds. Herein, a miniaturized, wireless, battery‐free wound monitor that measures lactate in real‐time and seamlessly integrates with bandages for conformal attachment to the wound bed is introduced. Lactate is selected due to its multifaceted role in initiating healing. Studies in healthy and diabetic mice reveal distinct lactate profiles for normal and impaired healing wounds. A mathematical model based on the sensor data predicts wound closure rate within the first 3 days post‐injury with ≈76% accuracy, which increases to ≈83% when pH is included. These studies underscore the significance of monitoring biomarkers during the inflammation phase, which can offer several benefits, including short‐term use of wound monitors and their easy removal, resulting in lower risks of injury and infection at the wound site. Improvements in prediction accuracy can be achieved by designing mathematical models that build on multiple wound parameters such as pro‐inflammatory and metabolic markers. Achieving this goal will require designing multi‐analyte wound monitors.

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Designing electrospun shellac nanofibers with mupirocin using the Box-Behnken approach for topical wound care

Cited by 5 publications

References 14 publications

Fabrication, Optimization, and Characterization of Antibacterial Electrospun Shellac Fibers Loaded with Kaempferia parviflora Extract

Fabrication, Optimization, and Characterization of Antibacterial Electrospun Shellac Fibers Loaded with Kaempferia parviflora Extract

Advances in Natural Product Extraction Techniques, Electrospun Fiber Fabrication, and the Integration of Experimental Design: A Comprehensive Review

A Miniaturized, Battery‐Free, Wireless Wound Monitor That Predicts Wound Closure Rate Early

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