Desing, synthesis, and characterization of some 5,6‐dichloro benzimidazole derivatives with investigation of their antioxidant and elastase inhibitory activities

Abstract

Starting from the 5,6‐dichloro‐2‐phenyl‐1H‐benzimidazole, new benzimidazole derivatives having schiff base, carbothioamide, thiadiazole, and triazole moiety were synthesized and characterized. Synthesized compounds were characterized by NMR spectroscopy, mass spectroscopy and elemental analyses techniques. Antioxidant and elastase inhibitory activities of compounds were also investigated. The inhibitory effects on elastase activity of the synthesized molecules were analyzed spectrophotometrically. The antioxidant activities of molecules were investigated by both methods as DPPH (1,1‐diphenyl‐2‐picrylhydrazyl) free radical scavenging activity and iron reducing power capacities. All synthesized compounds showed good antioxidant and elastase inhibitory activity. Compound 2 showed the highest elastase inhibition. Compound 3 and compound 2 showed the highest antioxidant activity by DPPH method, and iron reducing power method, respectively.

Yeşil Sentez: Nano Partiküller ve Potansiyel Uygulama Alanları

“…In the study conducted by Albay et al (2023), new benzimidazole derivatives were synthesized, and their enzyme inhibition and antioxidant activities were investigated. Methods such as DPPH free radical scavenging and iron-reducing power activities were used to determine elastase inhibition capacities in enzyme inhibition tests and two different antioxidant capacities in antioxidant tests.…”

“…Another of the synthesized compounds showed the highest antioxidant activity with DPPH. These two compounds are shown below [25]. DPPH SC 50 (μM): 407.21 ± 33.998 Shinde et al (2023) synthesized a number of novel benzimidazole compounds with high yields.…”