Desmin and nerve terminal expression during embryonic development of the lateral pterygoid muscle in mice

Yamamoto, Masahito; Shinomiya, Takashi; Kishi, Asuka; Yamane, Shigeki; Umezawa, Taishi; Ide, Yoshinobu; Abe, Shinichi

doi:10.1016/j.archoralbio.2014.03.011

Cited by 9 publications

(6 citation statements)

References 32 publications

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“…It has been shown that aldolase, a key enzyme in glycolysis, contributes to muscle maintenance and striated muscle contraction (Du et al, ). Desmin expression was reported to increase during muscle development, and it has therefore, been used as a muscle development‐specific marker (Yamamoto et al, ). MCK is one of the most abundant transcripts in the striated muscle and is differentially expressed in fast‐ and slow‐twitch muscle fibers (Welle et al, ; Tai et al, ).…”

Section: Discussionmentioning

confidence: 99%

Fibroblast Growth Factor 21 (FGF21) Promotes Formation of Aerobic Myofibers via the FGF21‐SIRT1‐AMPK‐PGC1α Pathway

Liu

Wang

Hou

et al. 2017

Journal Cellular Physiology

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Fibroblast growth factor 21(FGF21) is a pivotal regulator of energy metabolism, which is currently being assessed as a potential drug target for the treatment of insulin-resistant conditions. However, the cellular mechanisms by which FGF21 affects myogenesis remain unclear. In this study, we explored the function of FGF21 in myogenesis both in vitro and in vivo. Our experiments showed for the first time that FGF21 promotes myoblast differentiation and serves as a switch of molecular transformation from anaerobic myofibers to aerobic myofibers via the FGF21-SIRT1-AMPK-PGC1α axis. Furthermore, we employed the Dual-Luciferase Reporter Assay System and Electrophoretic Mobility Shift Assay (EMSA) and demonstrated that MYOD, a major myogenic transcription factor, binds directly to the promoter region of Fgf21, leading to the activation of Fgf21 expression in mouse C2C12 myoblasts. Our study revealed a novel mechanism of myogenesis and muscle fiber transformation and indicated that FGF21 serves as a vital regulator of muscle development and important contributor to the pathogenesis of myopathy. J. Cell. Physiol. 232: 1893-1906, 2017. © 2016 Wiley Periodicals, Inc.

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Section: Discussionmentioning

confidence: 99%

Fibroblast Growth Factor 21 (FGF21) Promotes Formation of Aerobic Myofibers via the FGF21‐SIRT1‐AMPK‐PGC1α Pathway

Liu

Wang

Hou

et al. 2017

Journal Cellular Physiology

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“…To determine whether Sox9 is expressed in muscle progenitor cells in vivo, we of double immunofluorescence staining with antibodies against desmin, which is a marker for muscle progenitors 11 , and Sox9 17,18 . In previous studies of head development 23,24 , we defined the cells in the desmin + area as the cranial paraxial mesoderm (CPM), from which the head muscle originates (Fig. 3a-c).…”

Section: Sox9 Expression In Muscle Progenitor Cells In Vivo Some Resmentioning

confidence: 99%

Switching of Sox9 expression during musculoskeletal system development

Nagakura

Yamamoto

Jeong

et al. 2020

Sci Rep

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The musculoskeletal system, which comprises muscles, tendons, and bones, is an efficient tissue complex that coordinates body movement and maintains structural stability. The process of its construction into a single functional and complex organization is unclear. SRY-box containing gene 9 (Sox9) is expressed initially in pluripotent cells and subsequently in ectodermal, endodermal, and mesodermal derivatives. This study investigated how Sox9 controls the development of each component of the musculoskeletal system. Sox9 was expressed in MTJ, tendon, and bone progenitor cells at E13 and in bone at E16. We detected Sox9 expression in muscle progenitor cells using doubletransgenic mice and myoblastic cell lines. However, we found no Sox9 expression in developed muscle. A decrease in Sox9 expression in muscle-associated connective tissues, tendons, and bones led to hypoplasia of the cartilage and its attachment to tendons and muscle. These results showed that switching on Sox9 expression in each component (muscle, tendon, and bone) is essential for the development of the musculoskeletal system. Sox9 is expressed in not only tendon and bone progenitor cells but also muscle progenitor cells, and it controls musculoskeletal system development. The musculoskeletal system comprises muscles, tendons, and bones. It is an efficient tissue complex that coordinates body movement and maintains structural stability 1. This requires effective linkage of muscles to bones. Many studies have reported the development of each component of the musculoskeletal system, but the process of its construction into a single functional and complex organization is unclear. Muscles, tendons, and bones differ in their developmental origins 2-8 , yet they interact during differentiation. Chen and Galloway 8 reported that artificial rupture of the myotome impedes syndetome formation. In contrast, cranial tendon progenitor cells emerge without dependence on muscles, yet muscle presence is essential for their normal differentiation 8. Huang et al 9. analyzed tendon development in forearms and fingers and found that tendons can be divided into a distal module showing cartilage-dependent development and a proximal module showing muscle-dependent development. In addition, the mechanical stress of muscle contraction affects the morphology of cartilage and bone during development 10. Previously, we found that mutual contact between muscles and the tendon-like structure immediately promotes the development of bones 11 and that there is a morphological association between muscles and bones 12. In summary, studies need to focus on the analysis of muscles, tendons, and bones as a single functional organ 13 rather than focusing on each as an independent tissue component. SRY-box containing gene 9 (Sox9) is a transcription factor essential for musculoskeletal system development. Sox9 is expressed in all cartilage progenitor cells and cartilage cells except hypertrophic chondrocytes 14,15 , and it plays a key role in a series of processes involved in endochondral...

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“…The period for desmin aggregation at the muscle end overlaps with when the mesoderm-derived myocyte precursor groups differentiate into individual muscles. This was described by Yamamoto et al, who reported that individual muscles mature after the position of the musculotendinous junction is determined by the precursor cells of the myocytes [15]. Their study found that tendons that differentiated from cranial neural crest cells play an important role in the formation of the musculotendinous junction at sites that are in contact with muscle; in other words, that some of the collagen fibers in the tendinous tissues are inserted into the muscle over time throughout the course of development.…”

Section: Development Of the Musculotendinous Junctionmentioning

confidence: 80%

Factors Involved in Morphogenesis in the Muscle–Tendon–Bone Complex

Abe

Yamamoto

2021

IJMS

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A decline in the body’s motor functions has been linked to decreased muscle mass and function in the oral cavity and throat; however, aging of the junctions of the muscles and bones has also been identified as an associated factor. Basic and clinical studies on the muscles, tendons and bones, each considered independently, have been published. In recent years, however, research has focused on muscle attachment as the muscle–tendon–bone complex from various perspectives, and there is a growing body of knowledge on SRY-box9 (Sox9) and Mohawk(Mkx), which has been identified as a common controlling factor and a key element. Myostatin, a factor that inhibits muscle growth, has been identified as a potential key element in the mechanisms of lifetime structural maintenance of the muscle–tendon–bone complex. Findings in recent studies have also uncovered aspects of the mechanisms of motor organ complex morphostasis in the superaged society of today and will lay the groundwork for treatments to prevent motor function decline in older adults.

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Desmin and nerve terminal expression during embryonic development of the lateral pterygoid muscle in mice

Cited by 9 publications

References 32 publications

Fibroblast Growth Factor 21 (FGF21) Promotes Formation of Aerobic Myofibers via the FGF21‐SIRT1‐AMPK‐PGC1α Pathway

Fibroblast Growth Factor 21 (FGF21) Promotes Formation of Aerobic Myofibers via the FGF21‐SIRT1‐AMPK‐PGC1α Pathway

Switching of Sox9 expression during musculoskeletal system development

Factors Involved in Morphogenesis in the Muscle–Tendon–Bone Complex

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