Desmin as a Possible Immunohistochemical Marker for Feline Hypertrophic Cardiomyopathy.

Hayman, Roslyn; Une, Yumi; Nomura, Yasuo

doi:10.1292/jvms.62.343

Cited by 1 publication

(1 citation statement)

References 12 publications

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“…Desmin extends from the Z-disks of the superficial myofibrils to the Z-region of the costameres in the sarcolemma (Capetanaki et al, 2015). It links the contractile apparatus to the costameres of the plasma membrane (Hayman et al, 2000;Clemen et al, 2013;Capetanaki et al, 2015).…”

Section: Desmin Structure and Functionmentioning

confidence: 99%

Structural and signaling proteins in the Z-disk and their role in cardiomyopathies

Noureddine

Gehmlich²

2023

Front. Physiol.

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The sarcomere is the smallest functional unit of muscle contraction. It is delineated by a protein-rich structure known as the Z-disk, alternating with M-bands. The Z-disk anchors the actin-rich thin filaments and plays a crucial role in maintaining the mechanical stability of the cardiac muscle. A multitude of proteins interact with each other at the Z-disk and they regulate the mechanical properties of the thin filaments. Over the past 2 decades, the role of the Z-disk in cardiac muscle contraction has been assessed widely, however, the impact of genetic variants in Z-disk proteins has still not been fully elucidated. This review discusses the various Z-disk proteins (alpha-actinin, filamin C, titin, muscle LIM protein, telethonin, myopalladin, nebulette, and nexilin) and Z-disk-associated proteins (desmin, and obscurin) and their role in cardiac structural stability and intracellular signaling. This review further explores how genetic variants of Z-disk proteins are linked to inherited cardiac conditions termed cardiomyopathies.

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