Desmoplastic fibroblastoma: a case presenting as a protruding nodule in the dermis

Abstract

Diffuse malignant peritoneal mesothelioma (DMPM) is a relatively rare neoplasm. Risk factors associated with its development include asbestos exposure, chronic irritation or inflammation of the peritoneum, abdominal radiotherapy, familial Mediterranean fever and simian virus 40. A familial segregation of this neoplasia has been reported in small villages of the Cappadocian region of Turkey, and it has been postulated that hereditary factors may predispose to mesothelioma, even with exposure to small amounts of asbestos. We report a case of DMPM, which apparently occurred in the absence of predisposing factors in a patient with a clinical history characterized by recurrent pre-sacral acne inversa of long duration. The association of this chronic inflammatory disease with DMPM has never been reported. The genetic locus for acne inversa has recently been identified within the 1p21.1-1q25.3 chromosomal region. Interestingly, frequent losses in chromosomal region 1p.21-22 have been found in mesothelioma as well. It is thus tempting to speculate that genetic mutations involving chromosome 1p.21-22 may account for the development of both diseases.

Clinicopathological Study of 13 Cases of Squamous Cell Carcinoma Complicating Hidradenitis Suppurativa

“…In many previously reported cases, tumors were found to penetrate the gluteal muscle, with 1 case of extension to the bony pelvis [35]. Similarly, in our series, 1 patient (case 12) presented with osteolysis of the sacrum as a consequence of tumoral infiltration.…”

“…This complication is uncommon: since 1958 only 52 cases have been published, most often as case reports – 27 cases were reported in a review in 1995 [15], which omitted 3 additional ones reported up to that time period [16,17,18], 22 additional cases were then published from 1995 to 2008 [19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36]. Lapins et al [37] reported 5 cases of ‘nonmelanoma skin cancer’ among a cohort that may contain some patients who did not have criteria for HS so we did not include those results.…”

Desmoplasia: not always a bad thing

“…This hypothesis claims that collagen production is induced by tumour cells, which cause activation of [73][74][75][76] ( Figure 5A Desmoplasia: not always a bad thing 647 fibroblasts and subsequent proliferation. 2,[6][7][8]14 This mechanism is also believed to promote the growth and invasiveness of tumours.…”

Dermal desmoplastic fibroblastoma presenting as a large sacral mass

“…Most of the reported cases have been located in the deep subcutaneous tissue, fascia or skeletal muscle. Dermal involvement, as seen in this case, is extremely rare . This neoplasm has been reported at various locations, including the arms, legs, chest wall, abdominal wall, upper back, neck, forehead and mucosal areas .…”