Most of the Italian infrastructures have been built since the mid‐twentieth century. Prestressed concrete (PC) has been widely used, especially for bridges and viaducts. These structures have proved effective over time, but their performance could be affected by degradation phenomena (i.e., corrosion of the tendons and residual prestressing) or construction defects (i.e., grouting of the ducts), which need to be accurately modeled. This paper focuses on the flexural response of two reduced‐scale, posttensioned, PC bridge girders, prestressed with two different jacking forces and tested under four‐point bending configuration. Four multidimensional numerical models were developed to simulate the experimental behaviors of the selected specimens, using two alternative computational strategies, namely, the finite element method (FEM) and applied element method (AEM). Three FEM modeling were considered, ranging from one‐dimensional lumped‐plasticity models to two‐dimensional and three‐dimensional (3D) spread‐plasticity models. Besides, 3D AEM models were developed into another software package. The accuracy and the computational costs of the two numerical strategies are discussed in this paper. Also, the main features of each numerical modeling technique are addressed, including comparisons between numerical and experimental global response data as well as the statistical characterization of the model error. Based on these different features, the authors also suggest the most suitable numerical strategy for future studies on PC girders.