Detecting inbreeding depression in structured populations
Eléonore Lavanchy,
Bruce S. Weir,
Jérôme Goudet
Abstract:Measuring inbreeding and its consequences on fitness is central for many areas in biology including human genetics and the conservation of endangered species. However, there is no consensus on the best method, neither for quantification of inbreeding itself nor for the model to estimate its effect on specific traits. We simulated traits based on simulated genomes from a large pedigree and empirical whole-genome sequences of human data from populations with various sizes and structures (from the 1,000 Genomes p… Show more
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