2021
DOI: 10.1017/cts.2021.856
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Detecting SARS-CoV-2 Orf3a and E ion channel activity in COVID-19 blood samples

Abstract: This version may be subject to change during the production process.

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Cited by 8 publications
(13 citation statements)
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“…[152][153][154] In COVID-19 these viral proteins were shown to respectively oligomerize and accumulate in the endoplasmic reticulum and in the Golgi apparatus; subsequently they can interact with the VGCC, based on the level of cell transmembrane charge potential, which ultimately leads to an alteration of the same cell membrane electro-chemical activity. [155][156][157][158] A few channels may be subsequently opened by viroporins from the inside of cell membrane, thus favoring the passage of extracellular cations into the cell and subsequent virus expulsion which results in NLRP3 inflammasome activation and cell apoptosis. [155][156][157] A number of viroporins have been described in coronaviruses and more specifically in SARS-CoV-2 infection, being protein E (from the envelope), ORF-3a and ORF-8a the most relevant ones.…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…[152][153][154] In COVID-19 these viral proteins were shown to respectively oligomerize and accumulate in the endoplasmic reticulum and in the Golgi apparatus; subsequently they can interact with the VGCC, based on the level of cell transmembrane charge potential, which ultimately leads to an alteration of the same cell membrane electro-chemical activity. [155][156][157][158] A few channels may be subsequently opened by viroporins from the inside of cell membrane, thus favoring the passage of extracellular cations into the cell and subsequent virus expulsion which results in NLRP3 inflammasome activation and cell apoptosis. [155][156][157] A number of viroporins have been described in coronaviruses and more specifically in SARS-CoV-2 infection, being protein E (from the envelope), ORF-3a and ORF-8a the most relevant ones.…”
Section: Introductionmentioning
confidence: 99%
“…[155][156][157][158] A few channels may be subsequently opened by viroporins from the inside of cell membrane, thus favoring the passage of extracellular cations into the cell and subsequent virus expulsion which results in NLRP3 inflammasome activation and cell apoptosis. [155][156][157] A number of viroporins have been described in coronaviruses and more specifically in SARS-CoV-2 infection, being protein E (from the envelope), ORF-3a and ORF-8a the most relevant ones. 63,[155][156][157] The ion-channeling action of these viroporins exacerbate calcium/iron intracellular accumulation, tending to reduce the transmembrane voltage furthermore.…”
Section: Introductionmentioning
confidence: 99%
“…[150][151][152] In COVID-19 these viral proteins were shown to respectively oligomerize and accumulate in the endoplasmic reticulum and in the Golgi apparatus; subsequently they can interact with the VGCC, based on the level of cell transmembrane charge potential, which ultimately leads to an alteration of the same cell membrane electro-chemical activity. [153][154][155][156] A few channels may be subsequently opened by viroporins from the inside of cell membrane, thus favoring the passage of extracellular cations into the cell and subsequent virus expulsion which results in NLRP3 inflammasome activation and cell apoptosis. [153][154][155] A number of viroporins have been described in coronaviruses and more specifically in SARS-CoV-2 infection, being protein E (from the envelope), ORF-3a and ORF-8a the most relevant ones.…”
Section: Introductionmentioning
confidence: 99%
“…[153][154][155][156] A few channels may be subsequently opened by viroporins from the inside of cell membrane, thus favoring the passage of extracellular cations into the cell and subsequent virus expulsion which results in NLRP3 inflammasome activation and cell apoptosis. [153][154][155] A number of viroporins have been described in coronaviruses and more specifically in SARS-CoV-2 infection, being protein E (from the envelope), ORF-3a and ORF-8a the most relevant ones. 61,[153][154][155] The ion-channeling action of these viroporins exacerbate calcium/iron intracellular accumulation, tending to reduce the transmembrane voltage furthermore.…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation