Detection and agreement of event-based OCT and OCTA analysis for glaucoma progression

Wu, Jo-Hsuan; Moghimi, Sasan; Nishida, Takashi; Mahmoudinezhad, Golnoush; Zangwill, Linda M.; Weinreb, Robert N.

doi:10.1038/s41433-023-02817-0

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2024

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Cited by 2 publications

References 47 publications

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Anatomy and Regulation of the Optic Nerve Blood Flow

Siesky,

Harris,

Kellner

et al. 2024

Reference Module in Neuroscience and Biobehavioral Psychology

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Anatomy and Regulation of the Optic Nerve Blood Flow

Siesky,

Harris,

Kellner

et al. 2024

Reference Module in Neuroscience and Biobehavioral Psychology

View full text Add to dashboard Cite

Diagnostic Capability of OCTA-Derived Macular Biomarkers for Early to Moderate Primary Open Angle Glaucoma

Verticchio Vercellin,

Harris,

Oddone

et al. 2024

JCM

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Background/Objectives: To investigate macular vascular biomarkers for the detection of primary open-angle glaucoma (POAG). Methods: A total of 56 POAG patients and 94 non-glaucomatous controls underwent optical coherence tomography angiography (OCTA) assessment of macular vessel density (VD) in the superficial (SCP), and deep (DCP) capillary plexus, foveal avascular zone (FAZ) area, perimeter, VD, choriocapillaris and outer retina flow area. POAG patients were classified for severity based on the Glaucoma Staging System 2 of Brusini. ANCOVA comparisons adjusted for age, sex, race, hypertension, diabetes, and areas under the receiver operating characteristic curves (AUCs) for POAG/control differentiation were compared using the DeLong method. Results: Global, hemispheric, and quadrant SCP VD was significantly lower in POAG patients in the whole image, parafovea, and perifovea (p < 0.001). No significant differences were found between POAG and controls for DCP VD, FAZ parameters, and the retinal and choriocapillaris flow area (p > 0.05). SCP VD in the whole image and perifovea were significantly lower in POAG patients in stage 2 than stage 0 (p < 0.001). The AUCs of SCP VD in the whole image (0.86) and perifovea (0.84) were significantly higher than the AUCs of all DCP VD (p < 0.05), FAZ parameters (p < 0.001), and retinal (p < 0.001) and choriocapillaris flow areas (p < 0.05). Whole image SCP VD was similar to the AUC of the global retinal nerve fiber layer (RNFL) (AUC = 0.89, p = 0.53) and ganglion cell complex (GCC) thickness (AUC = 0.83, p = 0.42). Conclusions: SCP VD is lower with increasing functional damage in POAG patients. The AUC for SCP VD was similar to RNFL and GCC using clinical diagnosis as the reference standard.

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Detection and agreement of event-based OCT and OCTA analysis for glaucoma progression

Cited by 2 publications

References 47 publications

Anatomy and Regulation of the Optic Nerve Blood Flow

Anatomy and Regulation of the Optic Nerve Blood Flow

Diagnostic Capability of OCTA-Derived Macular Biomarkers for Early to Moderate Primary Open Angle Glaucoma

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