Detection of a novel truncating Merkel cell polyomavirus large T antigen deletion in chronic lymphocytic leukemia cells

Pantulu, Naga Deepa; Pallasch, Christian P.; Kurz, Anna Kordelia; Kassem, Ahmad; Frenzel, Lukas P.; Sodenkamp, Sebastian; Kvasnicka, Hans Michael; Wendtner, Clemens; Hausen, Axel zur

doi:10.1182/blood-2010-02-269829

Cited by 88 publications

(92 citation statements)

References 21 publications

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“…The overall low prevalences (2-36 %) of viral DNA and large T-antigen (LT-Ag) detected in tumour tissue or peripheral blood mononuclear cells of CLL subjects (Shuda et al, 2009;Toracchio et al, 2009;Teman et al, 2011;Comar et al, 2012;Imajoh et al, 2012;Cimino et al, 2013) do not support an aetiological role. However, the presence of a truncated LT-Ag MCPyV sequence in the nucleus, a peculiarity of MCPyV in Merkel cell carcinoma cells, has been reported in highly purified CD19 + /CD5 + CLL cells (Haugg et al, 2011;Pantulu et al, 2010). Serology data are furthermore inconsistent; in a previous case-control study we identified an increased MCPyV seroprevalence in CLL patients (Robles et al, 2012) whereas in a recent paper a decreased risk was observed (Teras et al, 2015), although none of them significant.…”

Section: Received 9 January 2015mentioning

confidence: 57%

Seroreactivity against Merkel cell polyomavirus and other polyomaviruses in chronic lymphocytic leukaemia, the MCC-Spain study

Robles

Casabonne

Benavente

et al. 2015

Journal of General Virology

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Merkel cell polyomavirus (MCPyV) has been suspected to cause chronic lymphocytic leukaemia (CLL) but previous data are inconsistent. We measured seroreactivities of nine polyomaviruses (MCPyV, BKPyV, JCPyV, LPyV, KIPyV, WUPyV, HPyV-6, HPyV-7 and TSPyV) in 359 CLL cases and 370 controls using bead-based multiplex serology technology. We additionally tested two herpesviruses (HSV-1 and CMV). Associations between disease and viral seroreactivities were assessed using logistic regression. All human viruses showed high seroprevalences (69-99 %) against structural proteins in controls but significantly lower viral seroprevalences in cases (58-94 %; OR range50.21-0.70, P value ,0.05), except for MCPyV

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Section: Received 9 January 2015mentioning

confidence: 57%

Seroreactivity against Merkel cell polyomavirus and other polyomaviruses in chronic lymphocytic leukaemia, the MCC-Spain study

Robles

Casabonne

Benavente

et al. 2015

Journal of General Virology

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“…Detection of various levels of MCPyV DNA in B-cell lymphoproliferative disorders (46,91) is not a valid argument for an etiological link, as MCPyV is also detected in a wide range of control tissues. However, clonal integration and truncated mutation of MCPyV DNA, a molecular signature of MCPyV oncogenesis, were evidenced in a subset of patients with chronic lymphocytic leukemia (109). Whether MCPyV has a role in the pathogenesis of a subset of B-cell lymphoproliferative disorders remains to be demonstrated.…”

Section: Mcpyv and B-cell Proliferative Disordersmentioning

confidence: 99%

Human Merkel cell polyomavirus: virological background and clinical implications

Coursaget

Samimi

Nicol

et al. 2013

APMIS

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The Merkel cell polyomavirus (MCPyV), identified in humans in 2008, is associated with a relatively rare but aggressive neuroendocrine skin cancer, the Merkel cell carcinoma (MCC). MCC incidence is increasing due to the advancing age of the population, the increase in damaging sun exposure and in the number of immunocompromised individuals. MCPyV must be considered as the etiological agent of MCC and thus is the first example of a human oncogenic polyomavirus. MCPyV infection is common, and seroprevalence studies indicate that widespread exposure begins early in life. The majority of adults have anti-MCPyV antibodies and there is a growing body of evidence that healthy human skin harbors resident or transient MCPyV suggesting that MCPyV infection persists throughout life. However, the mode of transmission, the host cells, and the latency characteristics of this virus remain to be elucidated. In addition, it is still not clear whether MCPyV is associated with diseases or lesions other than Merkel cell carcinoma. The etiologic role of MCPyV in MCC opens up opportunities to improve the understanding of this cancer and to potentially improve its treatment.

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“…In previous studies conducted by Hashida et al (16) and Pantulu et al (18), MCPyV was found to be associated with the pathogenesis of non-small-cell lung cancer and chronic lymphocytic leukemia.…”

Section: Introductionmentioning

confidence: 99%

Low prevalence of Merkel cell polyomavirus with low viral loads in oral and maxillofacial tumours or tumour-like lesions from immunocompetent patients: Absence of Merkel cell polyomavirus-associated neoplasms

Tanio

Matsushita

Kuwamoto

et al. 2015

Molecular and Clinical Oncology

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Abstract. It was recently demonstrated that ~80% of Merkel cell carcinomas (MCCs) harbour a novel polyomavirus, Merkel cell polyomavirus (MCPyV). MCPyV has been detected in various human tissue samples. However, previous studies on the prevalence of MCPyV in oral tumours or tumour-like lesions are incomplete. To address this issue, we measured MCPyV DNA quantity using quantitative polymerase chain reaction (qPCR) in 327 oral tumours or tumour-like lesions and 54 jaw tumours or cyst lesions from 381 immunocompetent patients, as well as in 4 oral lesions from 4 immunosuppressed patients. qPCR revealed a low MCPyV prevalence (25/381, 6.6%) with low viral loads (0.00024-0.026 copies/cell) in oral and maxillofacial tumours and tumour-like lesions from immunocompetent patients. The prevalence was 7/176 (4.0%) in invasive squamous cell carcinomas (SCCs) [2/60 (3.33%) SCCs of the tongue, 4/52 (7.7%) SCCs of the gingiva and 1/19 (5.3%) SCCs of the floor of the mouth], 1/10 (10%) in dysplasias, 1/5 (20%) in adenocarcinomas, 2/13 (15.4%) in adenoid cystic carcinomas,

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Detection of a novel truncating Merkel cell polyomavirus large T antigen deletion in chronic lymphocytic leukemia cells

Cited by 88 publications

References 21 publications

Seroreactivity against Merkel cell polyomavirus and other polyomaviruses in chronic lymphocytic leukaemia, the MCC-Spain study

Seroreactivity against Merkel cell polyomavirus and other polyomaviruses in chronic lymphocytic leukaemia, the MCC-Spain study

Human Merkel cell polyomavirus: virological background and clinical implications

Low prevalence of Merkel cell polyomavirus with low viral loads in oral and maxillofacial tumours or tumour-like lesions from immunocompetent patients: Absence of Merkel cell polyomavirus-associated neoplasms

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