Detection of Abnormal Visual Cortex in Children With Amblyopia by Voxel-Based Morphometry

Grey and white matter changes in children with monocular amblyopia: voxel-based morphometry and diffusion tensor imaging study

“…Previous studies about amblyopia have suggested that besides the primary visual cortex, there are deficits at the higher levels of the visual pathway as well 8 9 11. This statement is supported by this study,where cortices related tospatial vision were found to undergo morphological changes in patients with monocular amblyopia.…”

Gray matter alterations in visual cortex of patients with loss of central vision due to hereditary retinal dystrophies

“…Similar results are shown for early blind adults, who lost sight before the age of two (Noppeney et al, 2005) or before the age of six (Pan et al, 2007). Abnormalities in the structure of the visual cortex are also detected in children and adults with amblyopia (Mendola et al, 2005;Xiao et al, 2007), as well as in albinism (Hoffmann et al, 2003). Furthermore studies on albinos found differences in the visual pathways (Schmitz et al, 2003) and a reduction of gray matter in the foveal representation area of the visual cortex, assumed to occur as a consequence of a decreased number of ganglion cells in the fovea (Von dem Hagen et al, 2005).…”

Occipital lobe's cortical thinning in ametropic amblyopia

“…All of the factors hinder the development of the visual related area in the brain. Studies using the VBM method demonstrate that the gray matter volumes of the gyrus frontalis medius, gyrus hippocampi and temporal gyrus are reduced [16]. Some scholars also suggest that the decrease in gray matter volume is due to the lack of orientation capability, depth perception and abnormal stereopsis [15].…”