Detection of an Antigen in Albumin Subjected to Repeated Heating

Abstract

Stabilized 5 and 25% normal serum albumin (human) derived from plasma, placentas and plasma-placental blends was subjected to repeated heating at 56 degrees C for 120 h, interspersed with storage at 4 degrees C for 48 h. Immunoelectrophoretic analyses showed that after the ninth heating, 5% plasma albumin developed a component which migrated in the alpha-globulin region and gave a reaction of nonidentity with albumin. This antigen, which was not detected in the other albumin samples, reacted with antiserum prepared against control 5% plasma albumin, indicating that it was present in the latter at an undetectably low concentration.

Analysis of clinical characteristics of SARS-CoV-2 infected cases: a retrospective study of medical records

“…in special cases, its decomposition can produce amino acids that participate in the synthesis of tissue proteins [14] , or oxidative decomposition to produce energy [15] . In addition, plasma albumin can also play a role in stabilizing globulin, which is of great significance in antiviral effect [16] . High fever and sweating after virus infection, acute dehydration caused by diarrhea and vomiting will lead to an increase in the concentration of serum albumin.…”