Detection of changes in the periaqueductal gray matter of patients with episodic migraine using quantitative diffusion kurtosis imaging: preliminary findings

Ito, Kenji; Kudo, Momonari; Sasaki, Makoto; Saito, Ayumi; Yamashita, Fumio; Harada, Taisuke; Yokosawa, Suguru; Uwano, Ikuko; Kameda, Hiroyuki; Terayama, Yasuo

doi:10.1007/s00234-015-1603-8

Cited by 27 publications

(34 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The current MRI study about the role of PAG in migraine genesis mainly focused on the voxel-based morphometry [12], resting-state functional MRI [22, 23], diffusion kurtosis imaging [24], positron emission tomography [25], and ion deposition study [1]. Conventional MRI studies reported the specific T2 lesions in PAG region which lead to migraine or migraine-like symptoms, and non-specific T2 lesions in PAG region was still not revealed up to now.…”

Section: Discussionmentioning

confidence: 99%

“…For the ring sign, it commonly was around the aqueductus mesencephali, and showed slight homogeneous hyperintensity. Based on the previous documents, it may be associated the ion deposition [1], frequent episodic activation [26], increased mean kurtosis and mean diffusivity value based on diffusion kurtosis imaging (DKI) [24] and altered functional connectivity [22], and this sign may be the direct imaging response for the intrinsic functional changes of PAG. While dot-ring sign always encircled the aqueductus mesencephali, and it may be associated with the ependyma [27], which would facilitates movement of iron, bound to ferritin, into brain and the neuron by the transferrin transporter [28–30].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Nonspecific periaqueductal gray lesions on T2WI in episodic migraine

Chen

Liu

et al. 2016

J Headache Pain

View full text Add to dashboard Cite

BackgroundThe specific periaqueductal gray (PAG) lesions with migraine-like headache were easily identified on conventional MR images in clinical practice, and the aim of this study is to investigate the nonspecific periaqueductal gray (PAG) lesions in episodic migraine (EM) patients based on T2 weighted imaging (T2WI).MethodsT2WI images were obtained from 18 EM patients and 18 normal controls (NC) on 3.0 T MR system. The images were observed by two experienced radiologists, and the lesions were identified on T2WI by consensus by 2 experienced neuroradiologists blinded to the patient identity. Chi-Square test was performed for the significance test.ResultsRing-like hyperintensity lesions (HILs) around the PAG region were observed in 14 EM patients and in 5 NCs on T2WI. Four EM patients and 13 NCs were normal in PAG region. The significance was revealed by Chi-Square test (P = 0.003).ConclusionHIL of PAG may be the direct evidence of the EM genesis, and the further structural and functional study should be performed to elucidate the neuromechanism of migraine pathogenesis.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Nonspecific periaqueductal gray lesions on T2WI in episodic migraine

Chen

Liu

et al. 2016

J Headache Pain

View full text Add to dashboard Cite

show abstract

“…In this context, further studies are worthwhile to determine whether the microstructural changes in the PAG and its abnormal connectivity with the prefrontal cortex (47,48), particularly with worsening of attack frequency (49) and intensity (50), may be primary dysfunctions or secondary maladaptive consequences of the abnormal connectivity between networks during the migraine cycle.…”

Section: Dmn-to-ins Correlation With Severity Of Migraine Headachementioning

confidence: 99%

Resting state connectivity between default mode network and insula encodes acute migraine headache

et al. 2017

View full text Add to dashboard Cite

Background: Previous functional MRI studies have revealed that ongoing clinical pain in different chronic pain syndromes is directly correlated to the connectivity strength of the resting default mode network (DMN) with the insula. Here, we investigated seed-based resting state DMN-insula connectivity during acute migraine headaches. Methods: Thirteen migraine without aura patients (MI) underwent 3 T MRI scans during the initial six hours of a spontaneous migraine attack, and were compared to a group of 19 healthy volunteers (HV). We evaluated headache intensity with a visual analogue scale and collected seed-based MRI resting state data in the four core regions of the DMN: Medial prefrontal cortex (MPFC), posterior cingulate cortex (PCC), and left and right inferior parietal lobules (IPLs), as well as in bilateral insula. Results: Compared to HV, MI patients showed stronger functional connectivity between MPFC and PCC, and between MPFC and bilateral insula. During migraine attacks, the strength of MPFC-to-insula connectivity was negatively correlated with pain intensity. Conclusion: We show that greater subjective intensity of pain during a migraine attack is associated with proportionally weaker DMN-insula connectivity. This is at variance with other chronic extra-cephalic pain disorders where the opposite was found, and may thus be a hallmark of acute migraine head pain.

show abstract

“…Current studies [6, 7] supported that PAG network participated in the migraine, which may impair the descending pain modulatory. In episodic migraine (EM) paitents, it had been detected for the nonspecific PAG lesions on T2WI [8], impaired iron homeostasis of PAG [1], and increased mean kurtosis and mean diffusivity on diffusion kurtosis imaging [9]. …”

Section: Introductionmentioning

confidence: 99%

Disrupted functional connectivity of periaqueductal gray subregions in episodic migraine

Chen

Liu

et al. 2017

J Headache Pain

View full text Add to dashboard Cite

BackgroundThe periaqueductal gray (PAG) dysfunction was recognized in migraine, and the altered dysfunction of PAG subregions were not totally detected up to now. The aim of this study is to investigate the altered functional connectivity of PAG subregions in EM patients.MethodsThe brain structural images and resting state functional MR imaging (rs-fMRI) data were obtained from 18 normal controls (NC) and 18 EM patients on 3.0 T MR system. Seven subregions of PAG were classified as bilateral ventrolateral PAG (vlPAG), lateral PAG (lPAG), dorsolateral PAG (dlPAG) and dorsomedial PAG (dmPAG). The functional connectivity maps of each PAG subregion were calculated, and Two sample t-test was applied with age and sex as covariables.ResultsBilateral vlPAG and left dlPAG presented decreased functional connectivity, and the other subregions (bilateral lPAGs, right dlPAG and dmPAG) showed no significant altered functional connectivity in EM compared with NC. The brain regions with decreased functional connectivity mainly located in bilateral prefrontal cortex(PFC), middle temporal gyrus, primary motor area (PMA) and supplementary motor area (SMA) and right ventrolateral PFC (vlPFC) in EM patients in this study. Disease duration was positively related to the functional connectivity of bilateral vlPAG on the bilateral thalamus and putamen, left pallidum and right medial orbitofrontal gyrus in EM patients.ConclusionThe present study suggested that the dysfunction of bilateral vlPAG and left dlPAG presented in EM, and functional evaluation of PAG subregions may be help for the diagnosis and understanding of EM pathogenesis.

show abstract

Detection of changes in the periaqueductal gray matter of patients with episodic migraine using quantitative diffusion kurtosis imaging: preliminary findings

Abstract: Introduction: The periaqueductal gray mater (PAG) is considered to play an important

Cited by 27 publications

References 31 publications

Nonspecific periaqueductal gray lesions on T2WI in episodic migraine

Nonspecific periaqueductal gray lesions on T2WI in episodic migraine

Resting state connectivity between default mode network and insula encodes acute migraine headache

Disrupted functional connectivity of periaqueductal gray subregions in episodic migraine

Contact Info

Product

Resources

About