Detection of Device Infection Using Nuclear Cardiology Imaging

Sollini, Martina; Berchiolli, Raffaella; Bandera, Francesco; Lazzeri, Elena; Erba, Paola Anna

doi:10.17996/anc.18-00078

Cited by 8 publications

(2 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This (r)evolution has been the consequence of the availability of hybrid imaging. Moreover, functional multimodal imaging has become the standard of care in several clinical conditions including cardiovascular infections ( 14 , 15 ). Autologous radiolabeled leukocytes white blood cell single-photon emission CT/CT ( 99m Tc-HMPAO-WBC SPECT/CT) and 18-fluoride-fluorodeoxyglucose PET/CT ([ 18 F]FDG PET/CT) significantly contribute to infection diagnosis.…”

Section: Introductionmentioning

confidence: 99%

Role of Multimodal Imaging in Patients With Suspected Infections After the Bentall Procedure

Sollini

Bartoli

Boni

et al. 2021

Front. Cardiovasc. Med.

Self Cite

View full text Add to dashboard Cite

Purpose: This study aimed to assess the diagnostic performances of multimodal imaging [i.e., white blood cell single-photon emission computed tomography/CT (99mTc-HMPAO-WBC SPECT/CT) and 18-fluoride-fluorodeoxyglucose positron emission tomography/CT ([18F]FDG PET/CT)] in patients with suspected infection after the Bentall procedure, proposing new specific diagnostic criteria for the diagnosis.Methods: Between January 2009 and December 2019, we selected within a cardiovascular infections registry, 76 surgically treated patients (27 women and 49 men, median 66 years, and range 29–83 years). All the patients underwent molecular imaging for a suspected infection after the replacement of the aortic valve and ascending aorta according to the Bentall procedure. We analyzed 98 scans including 49 99mTc-WBC and 49 [18F]FDG PET/CT. A total of 22 patients with very early/early suspected infection (<3 months after surgery) were imaged with both the techniques. Positive imaging was classified according to the anatomical site of increased uptake: to the aortic valve (AV), to both the AV and AV tube graft (AVTG) or to the TG, to surrounding tissue, and/or to extracardiac sites (embolic events or other sites of concomitant infection). Standard clinical workup included in all the patients having echocardiography/CT, blood culture, and the Duke criteria. Pretest probability and positive/negative likelihood ratio were calculated. Sensitivity and specificity of 99mTc labeled hexamethylpropylene amine oxime-WBC SPECT/CT (99mTc-HMPAO-WBC SPECT/CT) and [18F]FDG PET/CT imaging were calculated by using microbiology (n = 35) or clinical follow-up (n = 41) as final diagnosis. 99mTc-HMPAO-WBC scintigraphy and [18F]FDG PET/CT findings were compared with 95% CIs by using the McNemar test to those of echocardiography/CT, blood culture, and the Duke criteria.Results: Sensitivity, specificity, and accuracy of 99mTc-HMPAO-WBC were 86, 92, and 88%, respectively, with a slightly higher sensitivity for tube graft infection (TGI) as compared to isolated AV and combined AVTG. Overall, sensitivity, specificity, and accuracy of [18F]FDG PET/CT were 97, 73, and 90%, respectively. In 22 patients with suspected very early and early postsurgical infections, the two imaging modalities were concordant in 17 cases [10 true positive (TP) and 7 true negative (TN)]. [18F]FDG PET/CT presented a higher sensitivity than 99mTc-HMPAO-WBC scan. 99mTc-HMPAO-WBC scan correctly classified as negative three false-positive (FP) PET/CT findings.Conclusion: Our findings supported the use of 99mTc-HMPAO-WBC SPECT/CT and [18F]FDG PET/CT in patients with suspicion infection after the Bentall procedure early in the course of the disease onset to confirm the diagnosis and provide a comprehensive assessment of disease burden through the proposed criteria.

show abstract

Section: Introductionmentioning

confidence: 99%

Role of Multimodal Imaging in Patients With Suspected Infections After the Bentall Procedure

Sollini

Bartoli

Boni

et al. 2021

Front. Cardiovasc. Med.

Self Cite

View full text Add to dashboard Cite

show abstract

“…Increasingly, the value of PET/CT is recognized to evaluate various aspects of ischemic heart disease, including absolute myocardial blood flow (MBF), coronary flow reserve (CFR) and myocardial viability (2). In addition, cardiac involvement by inflammatory disease such as sarcoidosis, as well as infective endocarditis of prosthetic heart valves have become common indications for cardiac PET/CT (3,4). Image quality of nuclear cardiology (NC) studies is much improved by the routine use of CT based attenuation correction on PET/CT and higher energy positron rather than SPECT imaging.…”

mentioning

confidence: 99%

Worldwide Availability and Utilization of PET/CT from IAEA Survey

Vítola

Dondi²,

Prado

et al. 2019

Annals of Nuclear Cardiology

View full text Add to dashboard Cite

Hybrid imaging using PET/CT have various applications in cardiology. Anatomy, physiology or both can be evaluated. Routine attenuation correction can be performed and improve accuracy for nuclear cardiology studies. The extent of availability and utilization of hybrid imaging technology worldwide is currently unknown. The International Atomic Energy Agency (IAEA) in cooperation with QUANTA performed a web-based survey among physicians working with nuclear imaging to evaluate the current availability of hybrid imaging and its use for nuclear cardiology (NC). Contact e mails of physicians working in the field of nuclear cardiology were available from a data base at the human health department of the IAEA in Vienna, Austria and an international network of nuclear cardiologist at QUANTA in Curitiba, Brazil. Data from 80 countries in both high-income countries (HIC, n=16) and low-and-middle income countries (LMIC, n=64) representing all world regions, was obtained. At the country level, PET/CT is available in all world regions being widely available in North and Latin America, Europe, Asia and Oceania with a heterogeneous availability in Africa. Nevertheless, only 22.4% of centers in HIC and 10.9% in LMIC that have PET/CT available use it for NC applications. These data will help us to work with scientific societies and institutions to design strategies to diffuse information for physicians so they can take full advantage of PET/CT technology to obtain additional information that could impact patient care.

show abstract

2-[18F]FDG PET Imaging of Infection and Inflammation

Minamimoto

2021

Nuclear Medicine and Immunology

View full text Add to dashboard Cite

Detection of Device Infection Using Nuclear Cardiology Imaging

Cited by 8 publications

References 51 publications

Role of Multimodal Imaging in Patients With Suspected Infections After the Bentall Procedure

Role of Multimodal Imaging in Patients With Suspected Infections After the Bentall Procedure

Worldwide Availability and Utilization of PET/CT from IAEA Survey

2-[18F]FDG PET Imaging of Infection and Inflammation

Contact Info

Product

Resources

About