Detection of Distinct Changes in Gene-expression Profiles in Specimens of Tumors and Transition Zones of Tenascinpositive/- negative Head and Neck Squamous Cell Carcinoma

Živicová, Veronika; Gál, Péter; Mifkova, Alzbeta; Novák, S; Kaltner, Herbert; Kolář, Michal; Strnad, Hynek; Šáchová, Jana; Hradilová, Miluše; Chovanec, Martin; Gabius, Hans‐Joachim; Smetana, Karel; Fík, Zdeněk

doi:10.21873/anticanres.12350

Cited by 11 publications

(9 citation statements)

References 25 publications

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“…On the other hand, the galectin-1-rich tumour stroma was not proved as a biomarker of poor patient survival [116,117]. Conversely, low expression of tenascin-C and fibronectin in cancer tissues is typical in low-risk patients, namely in the early stages of the disease [118].…”

Section: Specificity Of the Hnscc Microenvironmentmentioning

confidence: 99%

The Head and Neck Squamous Cell Carcinoma Microenvironment as a Potential Target for Cancer Therapy

Plzák

Bouček

Bandúrová

et al. 2019

Cancers

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Similarly to other types of malignant tumours, the incidence of head and neck cancer is increasing globally. It is frequently associated with smoking and alcohol abuse, and in a broader sense also with prolonged exposure to these factors during ageing. A higher incidence of tumours observed in younger populations without a history of alcohol and tobacco abuse may be due to HPV infection. Malignant tumours form an intricate ecosystem of cancer cells, fibroblasts, blood/lymphatic capillaries and infiltrating immune cells. This dynamic system, the tumour microenvironment, has a significant impact on the biological properties of cancer cells. The microenvironment participates in the control of local aggressiveness of cancer cells, their growth, and their consequent migration to lymph nodes and distant organs during metastatic spread. In cancers originating from squamous epithelium, a similarity was demonstrated between the cancer microenvironment and healing wounds. In this review, we focus on the specificity of the microenvironment of head and neck cancer with emphasis on the mechanism of intercellular crosstalk manipulation for potential therapeutic application.

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Section: Specificity Of the Hnscc Microenvironmentmentioning

confidence: 99%

The Head and Neck Squamous Cell Carcinoma Microenvironment as a Potential Target for Cancer Therapy

Plzák

Bouček

Bandúrová

et al. 2019

Cancers

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“…Human Gal-8 is a tandem-repeat type family member with two different carbohydrate recognition domains (CRDs) connected by a linker peptide of either 33 amino acids (Gal-8S) or 75 amino acids (Gal-8L) [ 24 – 26 ]. It is abundantly expressed in human tissues [ 27 , 28 ] and an integral part of the galectin signature of many tumor types such as colon, head and neck, prostate and urothelial carcinomas [ 29 – 34 ]. Cell biologically, it acts as matricellular protein: it can reduce cell adhesion when present in excess in solution by blocking access to integrins or promote cell attachment when adsorbed to a substratum [ 35 ].…”

Section: Introductionmentioning

confidence: 99%

Galectin-8 induces functional disease markers in human osteoarthritis and cooperates with galectins-1 and -3

Weinmann

Kenn

Schmidt

et al. 2018

Cell. Mol. Life Sci.

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The reading of glycan-encoded signals by tissue lectins is considered a major route of the flow of biological information in many (patho)physiological processes. The arising challenge for current research is to proceed from work on a distinct protein to family-wide testing of lectin function. Having previously identified homodimeric galectin-1 and chimera-type galectin-3 as molecular switches in osteoarthritis progression, we here provide proof-of-principle evidence for an intra-network cooperation of galectins with three types of modular architecture. We show that the presence of tandem-repeat-type galectin-8 significantly correlated with cartilage degeneration and that it is secreted by osteoarthritic chondrocytes. Glycan-inhibitable surface binding of galectin-8 to these cells increased gene transcription and the secretion of functional disease markers. The natural variant galectin-8 (F19Y) was less active than the prevalent form. Genome-wide array analysis revealed induction of a pro-degradative/inflammatory gene signature, largely under control of NF-κB signaling. This signature overlapped with respective gene-expression patterns elicited by galectins-1 and -3, but also presented supplementary features. Functional assays with mixtures of galectins that mimic the pathophysiological status unveiled cooperation between the three galectins. Our findings shape the novel concept to consider individual galectins as part of a so far not realized teamwork in osteoarthritis pathogenesis, with relevance beyond this disease.Electronic supplementary materialThe online version of this article (10.1007/s00018-018-2856-2) contains supplementary material, which is available to authorized users.

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“…In the most classical view, fibroblasts are responsible for the maintenance of the structural integrity of connective tissues. Similar to other types of fibroblasts, CAFs also produce molecules of ECM, such as collagen, hyaluronic acid, fibronectin, periostin, and tenascin [94][95][96][97][98][99][100][101]. ECM production by CAFs seems to be more extensive than in normal fibroblasts, and it even reflects the severity of the disease.…”

Section: Production and Remodelling Of Ecmmentioning

confidence: 98%

Cancer-Associated Fibroblasts Influence the Biological Properties of Malignant Tumours via Paracrine Secretion and Exosome Production

Vokurka

Lacina

Brábek

et al. 2022

IJMS

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Cancer-associated fibroblasts (CAFs) are an essential component of the tumour microenvironment. They represent a heterogeneous group of cells that are under the control of cancer cells and can reversely influence the cancer cell population. They affect the cancer cell differentiation status, and the migration and formation of metastases. This is achieved through the production of the extracellular matrix and numerous bioactive factors. IL-6 seems to play the central role in the communication of noncancerous and cancer cells in the tumour. This review outlines the role of exosomes in cancer cells and cancer-associated fibroblasts. Available data on the exosomal cargo, which can significantly intensify interactions in the tumour, are summarised. The role of exosomes as mediators of the dialogue between cancer cells and cancer-associated fibroblasts is discussed together with their therapeutic relevance. The functional unity of the paracrine- and exosome-mediated communication of cancer cells with the tumour microenvironment represented by CAFs is worthy of attention.

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Detection of Distinct Changes in Gene-expression Profiles in Specimens of Tumors and Transition Zones of Tenascinpositive/- negative Head and Neck Squamous Cell Carcinoma

Abstract: The presented data reveal marked and specific changes in tumors and MSR specimens of HNSCC without a separation based on prognosis.

Cited by 11 publications

References 25 publications

The Head and Neck Squamous Cell Carcinoma Microenvironment as a Potential Target for Cancer Therapy

The Head and Neck Squamous Cell Carcinoma Microenvironment as a Potential Target for Cancer Therapy

Galectin-8 induces functional disease markers in human osteoarthritis and cooperates with galectins-1 and -3

Cancer-Associated Fibroblasts Influence the Biological Properties of Malignant Tumours via Paracrine Secretion and Exosome Production

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