2008
DOI: 10.1063/1.2832880
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Detection of DNA labeled with magnetic nanoparticles using MgO-based magnetic tunnel junction sensors

Abstract: We have demonstrated the detection of 2.5 M target DNA labeled with 16 nm Fe 3 O 4 nanoparticles ͑NPs͒ and 50 nm commercial MACS™ NPs using arrays of magnetic tunnel junction sensors with ͑001͒-oriented MgO barrier layers. Signal-to-noise ratios of 25 and 12 were obtained with Fe 3 O 4 and MACS™ NPs, respectively. These data show conclusively that MgO-based MTJ sensor arrays are very promising candidates for future applications involving the accurate detection and identification of biomolecules tagged with mag… Show more

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Cited by 68 publications
(40 citation statements)
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“…Although some efforts have been made to move these concepts into the bioanalytical arena (7)(8)(9)(10)(11)(13)(14)(15), there are few demonstrations of actual magnetic protein assays of either single or multiple analytes in a buffer or serum sample. In particular, multiple analytes require sophisticated biochemistry as well as control sensors on a single chip to ascertain sensitivity and selectivity at the same time.…”
Section: Discussionmentioning
confidence: 99%
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“…Although some efforts have been made to move these concepts into the bioanalytical arena (7)(8)(9)(10)(11)(13)(14)(15), there are few demonstrations of actual magnetic protein assays of either single or multiple analytes in a buffer or serum sample. In particular, multiple analytes require sophisticated biochemistry as well as control sensors on a single chip to ascertain sensitivity and selectivity at the same time.…”
Section: Discussionmentioning
confidence: 99%
“…Individual sensor microspotting (see SI) will allow the accommodation and simultaneous measurement of up to 64 different probes on a chip of the current generation. We expect that significant improvements can also be made on the sensor, for example, using magnetic tunnel junction sensors (9,22) instead of spin valves, and by using sensors with narrower segments (16) (see SI). In the near future, capture agents with higher affinity, and similarly small but higher magnetic moment MNTs are all expected to enhance the analytic sensitivity of MNT-based assays further.…”
Section: Discussionmentioning
confidence: 99%
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“…7,8 The sensing platform of MTJ sensors together with MNPs has successfully been applied for detecting protein binding and DNA hybridization in previous studies. 2,4,9 In this work, we demonstrate the feasibility of detecting alpha-fetoprotein (AFP) tagged with 20-nm monodisperse iron-oxide MNPs using MgO-based MTJ sensors. Because the carriers of hepatitis B and C viruses suffer a high risk of developing HCC and AFP as a crucial hepatic tumor biomarker, it is very useful for early-stage liver cancer indications, and the biodetection of AFP will bring a revolutionary impact to clinical diagnostics and immunoassay for HCC biorecognition.…”
mentioning
confidence: 99%
“…[2][3][4][5] MgO-based MTJs experimentally demonstrated TMR ratio of 604% at room temperature, 6 and picotesla-sensitivity MTJ sensors are under intensive research. 7,8 The sensing platform of MTJ sensors together with MNPs has successfully been applied for detecting protein binding and DNA hybridization in previous studies.…”
mentioning
confidence: 99%