Detection of Endothelial Dysfunction Using Skin Temperature Oscillations Analysis During Local Heating in Patients With Peripheral Arterial Disease

Parshakov, A.A.; Зубарева, Н А; Podtaev, Sergey; Frick, Peter

doi:10.1111/micc.12283

Cited by 13 publications

(15 citation statements)

References 45 publications

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“…с атеросклерозом, которые были разделена на четыре группы в соответствии с клинической стадией ХАН. Помимо рутинных методов диагностики, в нашем исследовании мы определяли биохимические маркеры ЭД и использовали оригинальную методику инструментальной оценки микрососудистой функции, основанную на отслеживании изменений в колебаниях кожной температуры, вызванных локальным нагревом [29,32].…”

Section: таблицаunclassified

“…В основе метода ТВР лежит связь температуры и кожного кровотока и, как следствие, возможность изучения отклика температуры на внешние физиологические тесты. Уровень вазодилатации связан с активностью оксида азота, выделяемого эндотелием [28,29], и коррелирует с уровнем лабораторных маркеров у пациентов с ХАН [29].…”

Section: Introductionunclassified

“…Кожная температура и ее пульсации быстро восстанавливались до исходного уровня. Пациенты с ХАН демонстрировали сниженную вазодилатацию [29] и длительное восстановление.…”

Section: Introductionunclassified

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Microcirculation and biochemical markers of endothelial dysfunction after medical and surgical treatment in patients with peripheral arterial disease

Parshakov

Зубарева

Mizeva

et al. 2020

Regional blood circulation and microcirculation

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Состояние микроциркуляции и биохимические маркеры эндотелиальной дисфункции после медикаментозного лечения и хирургической коррекции кровотока у больных с атеросклерозом сосудов нижних конечностей 1 Федеральное государственное бюджетное образовательное учреждение высшего образования «Пермский государственный медицинский университет имени академика Е. А. Вагнера» Министерства здравоохранения Российской Федерации, г. Пермь, Россия 614000, Россия, г. Пермь, ул. Петропавловская, д. 26 2 Федеральное государственное бюджетное учреждение науки «Институт механики сплошных сред» Уральского отделения Российской академии наук, г. Пермь

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Section: таблицаunclassified

Section: Introductionunclassified

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Microcirculation and biochemical markers of endothelial dysfunction after medical and surgical treatment in patients with peripheral arterial disease

Parshakov

Зубарева

Mizeva

et al. 2020

Regional blood circulation and microcirculation

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“…In the present study we aimed to quantify the thermoregulation activity. In many previous studies, wavelet analysis was preferred to classical Fourier analysis, which led to insufficient time resolution for nonstationary physiological signals [8], [33], [34]. However, a windowed Fourier transform was possible and could be used to achieve a good time-frequency analysis, but selection of a proper window size for good time and frequency resolution was impossible when there were complex signals, such as SkBF [7].…”

Section: Wavelet Processing Toolmentioning

confidence: 99%

Proposal for a protocol using an infrared microbolometer camera and wavelet analysis to study foot thermoregulation

Serantoni

Jourdan

Louche

et al. 2019

Quantitative InfraRed Thermography Journal

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Here we propose a protocol to: (i) generate skin temperature (SkT) oscillations on glabrous tissues (plantar foot) in healthy subjects under controlled clinical environment conditions; (ii) measure quantitative temperature fields with an inexpensive microbolometer 2 (MB) infrared camera in a clinical environment; and (iii) quantify the characteristics of skin temperature (SkT) oscillations through spectral analysis. We paid particular attention to the metrology of thermal measurements, with a special bench, including four homemade black body reference areas. We propose a live calibration procedure using this setup while correcting the thermal drift. After all of these correction steps, the experimental thermal resolution () for the temporal variation in each pixel was about 25. Finally, a movement removal procedure was also applied to the thermal images to avoid foot spatial movement over the 10 min observation period. Thermoregulation was stimulated by a 6-min walking exercise test on six volunteers and was then studied using three kinds of scalar indicators evaluated before and after exercise per thermal image pixel. We demonstrated that the 6-min walk exercise increased the thermoregulation activity beneath the plantar foot sole. Moreover, unlike manually placed local thermal probes, the indicator fields proposed in this paper allow the operator to select the exact thermoregulation activation locations and analyse the spatial distribution patterns at these locations.

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“…Peripheral artery disease (PAD), which affects an estimated 200 million people globally [1], is characterized by the development of atherosclerotic plaques in the peripheral conduit arteries [2][3][4]. The most common manifestation of PAD is claudication, which includes symptoms such as leg pain, cramping, fatigue, pressure, and muscle weakness.…”

Section: Introductionmentioning

confidence: 99%

Microvascular Dysfunction in Peripheral Artery Disease: Is Heat Therapy a Viable Treatment?

Anderson

Pekas

Park

2021

IJERPH

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Peripheral artery disease (PAD) is characterized by the development of atherosclerotic plaques in the lower-body conduit arteries. PAD is commonly accompanied by microvascular disease, which may result in poor wound healing, plantar ulcer development, and subsequent limb amputation. Understanding the mechanisms underlying the development of plantar ulcers is a critical step in the development of adequate treatment options for patients with PAD. Skin is classified into two major components: glabrous and non-glabrous. These skin types have unique microcirculation characteristics, making it important to differentiate between the two when investigating mechanisms for plantar ulcer development in PAD. There is evidence for a microcirculation compensatory mechanism in PAD. This is evident by the maintenance of basal microcirculation perfusion and capillary filling pressure despite a reduced pressure differential beyond an occlusion in non-critical limb ischemia PAD. The major mechanism for this compensatory system seems to be progressive vasodilation of the arterial network below an occlusion. Recently, heat therapies have emerged as novel treatment options for attenuating the progression of PAD. Heat therapies are capable of stimulating the cardiovascular system, which may lead to beneficial adaptations that may ultimately reduce fatigue during walking in PAD. Early work in this area has shown that full-body heating is capable of generating an acute cardiovascular response, similar to exercise, which has been suggested as the most efficient treatment modality and may generate adaptations with chronic exposure. Heat therapies may emerge as a conservative treatment option capable of attenuating the progression of PAD and ultimately impeding the development of plantar ulcers.

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Detection of Endothelial Dysfunction Using Skin Temperature Oscillations Analysis During Local Heating in Patients With Peripheral Arterial Disease

Abstract: WAST can be considered as a low cost, portable, and easy to use technique for the noninvasive assessment of ED.

Cited by 13 publications

References 45 publications

Microcirculation and biochemical markers of endothelial dysfunction after medical and surgical treatment in patients with peripheral arterial disease

Microcirculation and biochemical markers of endothelial dysfunction after medical and surgical treatment in patients with peripheral arterial disease

Proposal for a protocol using an infrared microbolometer camera and wavelet analysis to study foot thermoregulation

Microvascular Dysfunction in Peripheral Artery Disease: Is Heat Therapy a Viable Treatment?

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