Detection of human papillomavirus in laryngeal squamous cell carcinoma: Systematic review and meta‐analysis

Gama, Ricardo Ribeiro; Carvalho, André L.; Longatto‐Filho, Adhemar; Scorsato, Anderson Paulo; López, Rossana Verónica Mendoza; Rautava, Jaana; Syrjänen, Stina; Syrjänen, Kari

doi:10.1002/lary.25738

Cited by 72 publications

(67 citation statements)

References 173 publications

(316 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Student's t test was used to analyze the differential expression of Annexin A2 between laryngeal cancer tissue and adjacent normal tissue. A χ 2 test was used to analyze the association between Annexin A2 expression and the clinicopathological parameters of patients with laryngeal cancer. Kaplan-Meier analysis with a log-rank test was used to examine the association between serum levels of Annexin A2 and overall survival (OS).…”

Section: Immunohistochemical (Ihc) Staining Assaymentioning

confidence: 99%

“…There is currently no established method of diagnosing laryngeal cancer. Furthermore, patients with laryngeal cancer have a high rate of recurrence and often develop resistance to chemotherapy or radiotherapy; therefore, the clinical outcome for patients with advanced laryngeal cancer remains poor (2,3). Thus, more effective diagnostic and therapeutic targets are required.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Annexin A2 is an independent prognostic biomarker for evaluating the malignant progression of laryngeal cancer

Luo

Xie

et al. 2017

Exp Ther Med

View full text Add to dashboard Cite

Abstract. Due to the lack of a definite diagnosis, a frequent recurrence rate and resistance to chemotherapy or radiotherapy, the clinical outcome for patients with advanced laryngeal cancer has not improved over the last decade. Annexin A2 is associated with the invasion and metastasis of cancer cells. In the present study, it was demonstrated using differential proteomics analysis that Annexin A2 is highly expressed in laryngeal carcinoma tissues and this was confirmed using immunohistochemistry, which demonstrated that the expression of Annexin A2 in laryngeal carcinoma tissues was significantly higher than in healthy adjacent tissue. In addition, its potential predictive value in the prognosis of patients with laryngeal carcinoma was evaluated. The results demonstrated that Annexin A2 expression was significantly associated with tumor size, lymph node metastasis, distant metastasis and clinical stage. In addition, higher Annexin A2 expression was associated with a poor prognosis of patients with laryngeal cancer. Thus, the results of the present study indicate that Annexin A2 expression is an independent prognostic biomarker for evaluating the malignant progression of laryngeal cancer.

show abstract

Section: Immunohistochemical (Ihc) Staining Assaymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Annexin A2 is an independent prognostic biomarker for evaluating the malignant progression of laryngeal cancer

Luo

Xie

et al. 2017

Exp Ther Med

View full text Add to dashboard Cite

show abstract

“…HPV infection status and p16 expression were evaluated in 211 LSCC patients from northeast China; 62.6% of patients were HPV+, a higher incidence than reported in a previous study that detected HPV DNA in 51% of LSCC patients in northeast China [21]. A recent comprehensive review showed that the prevalence of HPV in LSCC varied from 0% to 85% [22]. This variability may reflect the use of different detection techniques, different detection criteria, and different sampling procedures (biopsy, formalin fixation, or tissue freezing) as well as racial differences and regional variations [23][24][25].…”

Section: Tong Et Al: Prognostic Significance Of Hpc In Laryngeal Cancermentioning

confidence: 99%

Prevalence and Prognostic Significance of HPV in Laryngeal Squamous Cell Carcinoma in Northeast China

Tong

Geng

Yan

et al. 2018

Cell Physiol Biochem

View full text Add to dashboard Cite

Background/Aims: Human papillomavirus (HPV) is an etiological risk factor for a subset of head and neck squamous cell carcinomas. HPV has been proven to be a powerful prognostic biomarker for oropharyngeal cancer, but its role in the larynx has not been explored in depth. Here, we sought to evaluate the prevalence and genotype distribution of HPV in patients with laryngeal squamous cell carcinoma (LSCC) in northeast China. Methods: HPV DNA in specimens from 211 patients diagnosed with LSCC was analyzed by the polymerase chain reaction and in situ hybridization, and p16 overexpression was evaluated by immunohistochemistry. p16 expression was scored positive if strong and diffuse nuclear and cytoplasmic staining was present in >75% of tumor cells. Results: In this study, infection with HPV and p16 expression were not absolutely consistent. Among all patients, 132 (62.6%) were positive for HPV DNA (HPV+), while 23 (10.9%) were inconsistent for HPV and p16. Multivariate analysis indicated that HPV, but not p16, is an independent prognostic factor for overall survival in LSCC. Overall survival was significantly improved in HPV+ LSCC patients compared with the HPV-negative group (hazard ratio, 0.395; 95% confidence interval, 0.185-0.843; p = 0.016). Among the 132 HPV+ patients, 28 (21.2%) were HPV-16 single infection. Conclusion: This study indicates that HPV DNA is a more reliable surrogate marker than p16 for the prediction of survival in patients with LSCC.

show abstract

“…A favourable outcome for HPV-positive HNSCC patients could also be confirmed in this study. In addition, HPV infection is strongly associated with the onset of squamous cell carcinoma in the oral cavity and oropharynx and less in the larynx (reviewed in 27,28). Cancers of the oral cavity and oropharynx were also the tumours with the highest MB levels, whereas cancers of the larynx were mostly MB-negative.…”

Section: Discussionmentioning

confidence: 99%

Ectopic Myoglobin Expression Is Associated with a Favourable Outcome in Head and Neck Squamous Cell Carcinoma Patients

Meller

Ellen

Gevensleben

et al. 2016

View full text Add to dashboard Cite

Abstract. Background/Aim: Ectopic myoglobin (MB)expressionMyoglobin (MB) is a cytoplasmatic monomeric oxygenbinding hemoprotein known to be localized mainly in cardiac myocytes and mitochondrial-rich skeletal muscles. In contrast to its relative haemoglobin, MB is only found in the blood stream after muscle injury. The functional paradigm of MB is the storage and intracellular transport of oxygen (O 2 ) (1, 2) to the mitochondria for oxidative phosphorylation within the myocyte. However, MB also maintains homeostasis of the nitric oxide free radical (NO•) in muscle through scavenging or producing NO• molecules (3, 4) and appropriating excessive reactive oxygen species (ROS) (5). In addition, MB is able to bind fatty acids with physiological binding constants in vitro (6). On the other hand, MB-knockout mice are viable and exhibit normal exercise capacity but their survival depends on the activation of compensating mechanisms, i.e. increasing capillary densities and haematocrit (7,8).In the last years, the existence of non-muscle MB has been increasingly acknowledged, demonstrating MB, e.g., in the liver, brain or gills of carps (9) and in humans, 6235

show abstract

Detection of human papillomavirus in laryngeal squamous cell carcinoma: Systematic review and meta‐analysis

Abstract: NA.

Cited by 72 publications

References 173 publications

Annexin A2 is an independent prognostic biomarker for evaluating the malignant progression of laryngeal cancer

Annexin A2 is an independent prognostic biomarker for evaluating the malignant progression of laryngeal cancer

Prevalence and Prognostic Significance of HPV in Laryngeal Squamous Cell Carcinoma in Northeast China

Ectopic Myoglobin Expression Is Associated with a Favourable Outcome in Head and Neck Squamous Cell Carcinoma Patients

Contact Info

Product

Resources

About