Detection of Hypothyroid Myopathy by Measurement of Various Serum Muscle Markers &amp;ndash; Myoglobin, Creatine Kinase, Lactate Dehydrogenase and Their Isoenzymes

Giampietro, Ottavio; Clerico, A.; Buzzigoli, G.; Chicca, M.G. Del; Boni, Claudio De; Carpi, Angelo

doi:10.1159/000179893

Cited by 43 publications

(22 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…6 Giampietro et al 90%. 7 and Soufir et al 97%. 8 This increase in CK levels in hypothyroidism is due to various mechanisms.…”

Section: Discussionmentioning

confidence: 95%

Evaluation of Serum Creatine Kinase Levels in Patients With Hypothyroidism

Hemavathi¹,

Hanumanthaiah²

2016

jemds

View full text Add to dashboard Cite

BACKGROUNDThyroid disorders are common endocrine disorders. Thyroid function tests which are usually done are measurement of blood levels of hormones Triiodothyronine (T3), Thyroxine (T4) and Thyroid Stimulating Hormone (TSH), which are affected by various nonspecific conditions. Therefore, the present study is done to evaluate the role of additional biochemical parameter Creatine Kinase (CK) in diagnosing hypothyroidism. Thyroid function and Creatine Kinase activity was measured in 70 patients with clinically suspected cases of hypothyroidism. Patients with hypothyroidism will have decreased T3, T4 levels and increased levels of TSH. However, whether there is any correlation of Creatine Kinase with hypothyroidism is not well established. In our study, we found that in hypothyroid patients there is significant increase in CK levels. Measurement of CK levels is an additional biochemical parameter to diagnose hypothyroidism.

show abstract

“…6 Giampietro et al 90%. 7 and Soufir et al 97%. 8 This increase in CK levels in hypothyroidism is due to various mechanisms.…”

Section: Discussionmentioning

confidence: 95%

Evaluation of Serum Creatine Kinase Levels in Patients With Hypothyroidism

Hemavathi¹,

Hanumanthaiah²

2016

jemds

View full text Add to dashboard Cite

show abstract

“…In a study performed by Gianpietro et al to determined the most sensitive enzyme to investigated myopathy, the CPK was elevated in 60% cases, in the superior limit in 30% and normal in 10%, showing that this enzyme is the best biochemical marker for the investigation of myopathies, because it is a low cost method, sensitive and easy to perform 12 . The level of CPK does not relate to the clinical picture in the case of hypothyroidism, the patient may be symptomatic and have a normal CPK level, or the opposite 12,13 . The alteration of the level of CPK may vary from low elevations to extremely raised levels 14 .…”

Section: Discussionmentioning

confidence: 99%

Hoffman's syndrome: pseudohypertrophic myopathy as initial manifestation of hypothyroidism. Case report

Vasconcellos

Peixoto

Oliveira

et al. 2003

Arq. Neuro-Psiquiatr.

View full text Add to dashboard Cite

-The frequency of myopathy in hypothyroidism ranges from 30 to 80%. The major symptoms related are weakness, muscular cramps and myalgia. The pseudohyperthrophic form is called Hoffman's syndrome. The electrophysiological study reveals myopathy, neuropathy or mixed pattern. Laboratorial investigation generally shows increased levels of muscle enzymes and low serum thyroid hormones, with thyrotrophic-stimulating hormone (TSH) elevated. The treatment consists in hormone replacement and the prognosis is good in most of the cases. We report an adult male who developed muscular cramps, myalgia, weakness, pseudohyperthrophy, associated with facial edema and alteration of his voice. The muscle enzymes were increased and T4 was undetectable with a raised level of TSH. The myopathy was the initial manifestation of hypothyroidism in this case. Resumo -A frequência de miopatia no hipotireoidismo varia de 30% a 80%. Os sintomas relacionados ao acometimento muscular são fraqueza, cãimbras e mialgias. A forma pseudo-hipertrófica é denominada síndrome de Hoffman. O estudo eletrofisiológico pode revelar padrão miopático, neuropático ou misto. A investigação laboratorial em geral mostra aumento das enzimas musculares e redução dos níveis de hormônio tireoidiano com TSH elevado. O tratamento consiste na reposição oral de hormônio e o prognóstico é bom na maioria dos casos. Relatamos o caso de um adulto que apresentou cãimbras, mialgia, fraqueza com pseudohipertrofia muscular associados a edema facial e alteração da voz. As enzimas musculares estavam elevadas e o nível de T4 foi indetectável com aumento de TSH. A miopatia foi manifestação inicial de hipotireoidismo neste caso.

show abstract

“…Thyroxine (T4) affects energy metabolism. Deficient levels of T4 can lead to abnormalities of glycogenolysis, mitochondrial oxidative metabolism, and triglyceride turnover, all of which can impact muscle function [10]. Additionally, studies have linked a deficiency in skeletal muscle L-carnitine found in hypothyroid patients, which subsequently normalizes upon establishing a euthyroid state via hormone replacement [11].…”

Section: Discussionmentioning

confidence: 99%

Refractory Acute Kidney Injury Secondary to Hypothyroid-Induced Myopathy: A Contemporary Case Report

et al. 2017

View full text Add to dashboard Cite

This is a case report elucidating how severe hypothyroid-induced myopathy can lead to refractory kidney injury, unmanageable by standard medical and hemodialysis interventions. A 70-year-old female with extensive medical comorbidities including adult onset hypothyroidism, hypertension, hyperlipidemia, and normal baseline renal function presented with shortness of breath, myalgias, edema, and facial swelling. The patient was found to have a thyroid-stimulating hormone of 169.8 μIU/mL, creatine phosphokinase of 42,670 U/L, blood urea nitrogen of 70 mg/dL, a creatinine of 12.1 mg/dL, and glomerular filtration rate of 3 mL/min/1.73 m 2 . She was initiated on aggressive intravenous isotonic rehydration, along with intensive intravenous thyroid hormone replacement therapy and hydrocortisone treatment as well. Her renal status failed to improve adequately and she was started on sodium bicarbonate for urinary alkalinization. With the preceding interventions deemed medically futile for renal amelioration, the patient was started on acute hemodialysis. Over the course of 2 weeks and six hemodialysis treatments, the patient's renal status failed to improve. The patient finally refused any further hemodialysis or medical interventions seeing that her kidneys failed to respond to treatment, and her clinical prognosis remained poor. This case report illustrates how severe symptomatic hypothyroidism can induce rhabdomyolysis leading to intractable kidney failure, unmanageable by standard medical therapy and hemodialysis.

show abstract

Detection of Hypothyroid Myopathy by Measurement of Various Serum Muscle Markers – Myoglobin, Creatine Kinase, Lactate Dehydrogenase and Their Isoenzymes

Cited by 43 publications

References 12 publications

Evaluation of Serum Creatine Kinase Levels in Patients With Hypothyroidism

Evaluation of Serum Creatine Kinase Levels in Patients With Hypothyroidism

Hoffman's syndrome: pseudohypertrophic myopathy as initial manifestation of hypothyroidism. Case report

Refractory Acute Kidney Injury Secondary to Hypothyroid-Induced Myopathy: A Contemporary Case Report

Contact Info

Product

Resources

About