Detection of Internal and External Methamphetamine in Human Hair by Ion Mobility Spectrometry.

Miki, Akihiro; Keller, Thomas; Regenscheit, Prisca; Bernhard, Werner; Tatsuno, Michiaki; Katagi, Munehiro; Nishikawa, Mayumi; Kim, Lena; Hatano, Shigekazu; Tsuchihashi, Hitoshi

doi:10.1248/jhs1956.43.15

Cited by 8 publications

(4 citation statements)

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“…Thus, the authors devised a simple and rapid sample preparation process: a 2-mg portion of hair sample was digested with 5 M NaOH (methanolwater, 4 : 1; 200 µl), which sufficiently unbinds drugs from hair matrices to achieve their effective vaporization. 5) Ultrasonication at 45°C for 20 min resulted in the complete digestion of hair, and a 50 µl portion of the digest was then applied on a Teflon membrane filter. After drying it with a gentle stream of warm air for 60 sec, the sample was immediately measured using nicotinamide added automatically as the reactant and calibrant in the IMS instrument (IONSCAN model 250 ion mobility spectrometer; Barringer, Rexdale, Canada).…”

Section: Semiquantitative Screening Of Aps In Hair Using Ion Mobilitymentioning

confidence: 99%

“…In order to meet these requirements, the authors have developed three types of screening methods: ion mobility spectrometry (IMS)-based, [5][6][7][8] enzyme multiplied immunoassay technique (EMIT)-based, 9) and an immunochromatography-based method. 10) Also, an automated column-switching high performance liquid chromatographic-mass spectrometric (LC-MS) method has been established for the determination of amphetamines (APs) in hair extracts.…”

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confidence: 99%

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Recent Improvements in Forensic Hair Analysis for Illicit Drugs

Miki

Katagi

Tsuchihashi

2003

JOURNAL OF HEALTH SCIENCE

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This review summarizes technical and administrative improvements in forensic hair analysis for methamphetamine (MA) and designer drugs, recently developed by the present authors' team. These improvements include the establishment of three types of screening methods, and a column-switching liquid chromatographic-mass spectrometric (LC-MS) method for determining such drugs and their metabolites to serve as an alternative confirmation technique. The screening methods include ion mobility spectrometry-based, enzyme multiplied immunoassay technique (EMIT)-based, and immunochromatography-based methods. The column-switching LC-MS method proved to be effective in clearly determining MA and its metabolites, amphetamine and p-hydroxy-MA, which provides indisputable proof of MA intake. Quality assurance measures in forensic hair analysis, such as semiquantitative cross-checkings between the results of different analyses, are also discussed.

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Section: Semiquantitative Screening Of Aps In Hair Using Ion Mobilitymentioning

confidence: 99%

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confidence: 99%

Recent Improvements in Forensic Hair Analysis for Illicit Drugs

Miki

Katagi

Tsuchihashi

2003

JOURNAL OF HEALTH SCIENCE

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“…Currently, IMS is widely used as a rapid detection method for vapor phase analytes such as chemical warfare agents, explosives, drugs and air contaminants [31]. Pyrolysis-IMS and thermal desorption-IMS have also been applied for analysis of hair for drugs [32][33][34][35]. However, determination of non-volatiles present in hair is not feasible using pyrolysis-IMS and thermal desorption-IMS.…”

Section: Introductionmentioning

confidence: 99%

A rapid analytical method for hair analysis using ambient pressure ion mobility mass spectrometry with electrospray ionization (ESI-IMMS)

Dwivedi

Hill

2008

Int. J. Ion Mobil. Spec.

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Analysis of hair is often applied to assess drug abuse history, exposure to environmental and industrial pollutants, heavy metals, gestational drug exposure and various other screening purposes. This manuscript reports the application of ambient pressure ion mobility spectrometry mass spectrometry (IMMS) with electrospray ionization (ESI) source as a rapid analytical tool for hair analysis. The study demonstrated that ion mobility spectrometry (IMS) as a pre-separation technique prior to analysis by mass spectrometry (MS) provides detection and determination of compounds of interest present in hair at nano-molar concentration level. After extraction of analytes from hair, the ESI-IMMS method of analysis does not require the derivatization or sample treatment that is often required for other separation methods such as gas chromatography. One advantage of IMS over chromatography separation is that resolving powers are similar to those in GC and much greater than those possible by liquid chromatography. In addition, separation speed is faster than both gas and liquid chromatographic methods. Four of the nine hair samples anonymously donated by customers at a local hair salon tested positive for caffeine and two of the four samples that tested positive for caffeine also tested positive for nicotine. A positive response based on mass analysis for methamphetamine was obtained for one of the hair samples. Further investigation using the mobility data demonstrated that the response was a false positive and that it may have occurred from the use of a hair gel. This article reports the potential of IMMS as an analytical technique for rapid and routine screening of hair samples, cosmetics, and pharmaceuticals.

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“…Nevertheless they are also portable. Ion mobility spectrometry is for example used for the direct analysis of explosives [2][3][4][5][6][7][8][9][10][11], atmospheric and workplace pollutants [12][13][14][15][16], warfare agents [17,18] and tear gases [19,20] but also for the analysis of prescription and illicit drugs [21][22][23][24][25][26][27][28]. In forensic sciences the IMS methodology is mainly used as a detection device to prove the presence of latent traces of illicit drugs or explosives on surfaces of suspicious or confiscated material of evidence.…”

Section: Introductionmentioning

confidence: 99%