Detection of malignant bone marrow involvement with dynamic contrast-enhanced magnetic resonance imaging

Moulopoulos, Lia A.; Maris, Thomas G.; Papanikolaou, Nikolaos; Panagi, G.; Vlahos, L.; Dimopoulos, Meletios Α.

doi:10.1093/annonc/mdg007

Cited by 63 publications

(69 citation statements)

References 13 publications

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“…The parameters of metastatic bone lesions other than prostate were also not compared. Moulopoulos et al [21] evaluated cancer patients with metastasis to bone marrow including lymphoma, chronic lymphocytic leukemia, carcinoma of the cervix, breast, lung and bladder. They compared the wash-in and wash-out rates, time to peak, and time to maximum slope values of control group with no history of malignancy and reported a significant difference for all values.…”

Section: Discussionmentioning

confidence: 99%

Dynamic contrast-enhanced MR imaging findings of bone metastasis in patients with prostate cancer

Kayhan

Yang²,

Soylu³

et al. 2011

WJR

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AIM:To ev��u�te the dyn�mic contr�st-enh�nced m��-netic resonance imaging (DCE-MRI) findings of bone met�st�sis in prost�te c�ncer p�tients. METHODS:Sixteen men with � di��nosis o� met�st�tic prostate cancer to bones were examined with DCE-MRI �t 1.5 Tes��. The me�n contr�st ��ent concentr�tion vs time curves �or bone met�st�sis �nd norm�� bone were c��cu��ted �nd K tr�ns �nd ve v��ues were estim�ted �nd comp�red. RESULTS:An early significant enhancement (wash-out: n = 6�� p��te�u: n = 8 �nd persistent: n = 2) was detected in �� bone met�st�ses (n = 16

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Section: Discussionmentioning

confidence: 99%

Dynamic contrast-enhanced MR imaging findings of bone metastasis in patients with prostate cancer

Kayhan

Yang²,

Soylu³

et al. 2011

WJR

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“…Quantitative methods fit dynamic data with mathematical equations based on pharmacokinetic models and may assess physiological parameters of tissue microcirculation. In this study, dynamic data was fitted using a nonlinear regression analysis method (9,13,14). Slope-and time-related parameters of contrast kinetics and maximum enhancement were estimated.…”

Section: Discussionmentioning

confidence: 99%

“…ROI data were fitted by means of a nonlinear regression analysis method based on Marquardt algorithm, according to an exponentially modified Gaussian (EMG) equation, to generate fitted time-intensity curves (fTICs) (9,13,14):…”

Section: Mri Data Handling and Image Analysismentioning

confidence: 99%

“…Considering marrow perfusion, EMG can be viewed as a sharp and narrow width Gaussian pulse function when contrast perfuses into the plasma (bolus phase), it reshapes in time with a broadened exponentially modified Gaussian shape when contrast perfuses from plasma to the extravascular-extracellular space (EES) (wash-in phase) and then from the EES to the plasma (wash-out phase). EMG is an excellent means for quantifying the initial sigmoid rise of the fTIC in the vicinity of the start of data collection, as shown by goodness of the fits even with a relatively low time resolution and in various patient groups (9,13).…”

Section: Mri Data Handling and Image Analysismentioning

confidence: 99%

“…Maximum dynamic contrast enhancement (DCE max ) is depicted by the maximum function of the fTIC. Finally, the ratio WIN/TMSP (WTSP) reflects the rate of change of WIN values (9,13).…”

Section: Mri Data Handling and Image Analysismentioning

confidence: 99%

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Degenerative endplate changes of the lumbosacral spine: Dynamic contrast‐enhanced MRI profiles related to age, sex, and spinal level

Savvopoulou

Maris²,

Κουρέας

et al. 2011

Magnetic Resonance Imaging

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Purpose: To investigate differences in perfusion profiles between degenerative endplate marrow changes and normal vertebral marrow in relation to spinal level, age, and sex with dynamic contrast-enhanced magnetic resonance imaging (DCE MRI).Materials and Methods: Ninety-two consecutive patients referred for evaluation of low back pain or sciatica, without history of malignant or chronic disease, underwent conventional and DCE MRI of the lumbosacral spine. Fifty-two of them demonstrated degenerative endplate marrow changes. Regions of interest were placed on sites of normal marrow (group A) and degenerative changes (group B) on subtracted images. Fitted time-intensity curves (fTICs) were generated and evaluated for curve pattern. Both groups were stratified into upper (L1-L2) and lower (L3-I1) levels, males and females younger or older than 50 years. Perfusion parameters were calculated and statistically compared for both groups and subgroups. Receiver operator curve (ROC) analysis was also performed.Results: Two fTIC patterns were identified. Perfusion parameters of degenerative changes and normal marrow differed significantly, even when groups were stratified for spinal level, age, and sex (P < 0.05). A time to peak value >108 seconds was characteristic for degenerative changes with sensitivity 69.5% and specificity 84.6%.Conclusion: DCE MRI profiles of degenerative endplate marrow changes of the lumbosacral spine differ significantly from normal marrow regardless of spinal level, age, or sex.

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Neovascularization of bone marrow in patients with diffuse multiple myeloma

Baur

Bartl

Pellengahr

et al. 2004

Cancer

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BACKGROUNDThe goal of the current study was to assess the correlation between bone marrow histology and contrast enhancement in infiltrative diffuse myeloma.METHODSForty‐four patients with homogeneous diffuse infiltration of bone marrow by multiple myeloma were examined using magnetic resonance imaging of the spine. The sequence protocol included T1‐weighted spin‐echo (pre– and post–gadolinium dimeglumine administration) and short–inversion time inversion recovery sequences. The percent increase in signal after intravenous gadolinium administration was calculated in bone marrow from patients with myeloma and from a control group of 86 patients who did not have bone marrow disease. Grade of infiltration with plasma cells, fat cell content, and hematopoietic marrow content were evaluated via histologic assessment of bone marrow, and microvessel density was evaluated via anti‐CD34‐positive immunostaining.RESULTSIncreased microvessel density was observed in association with increasing plasma cell content (Kruskall–Wallis test: P < 0.0001). Contrast enhancement increased in a stepwise manner according to grade of microvessel density (Mann–Whitney U test: P < 0.05 and P < 0.001 for increases from low to intermediate and intermediate to high grade) and was significantly higher in patients with myeloma compared with control patients (Mann–Whitney U test: P < 0.001). A significant correlation also was found between histologic extent of tumor infiltration and contrast enhancement (Mann–Whitney U test: P < 0.0001). The mean level of contrast enhancement was 18% in the control group, 26% in patients with low‐grade infiltration, 49% in patients with intermediate‐grade infiltration, and 90% in patients with high‐grade infiltration. In addition, fat cell content was found to be inversely correlated with contrast enhancement (chi‐square test: P < 0.01).CONCLUSIONSAs a consequence of increased microvessel density, decreased fat cell content, and increased cellularity, the presence of diffuse bone marrow infiltration in patients with multiple myeloma can be verified using gadolinium‐enhanced magnetic resonance imaging. Cancer 2004. © 2004 American Cancer Society.

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Detection of malignant bone marrow involvement with dynamic contrast-enhanced magnetic resonance imaging

Abstract: dMRI can distinguish normal from malignant bone marrow. It may identify malignant bone marrow infiltration in patients with negative static MRI and serve as both a diagnostic and prognostic tool for patients with bone marrow malignancies.

Cited by 63 publications

References 13 publications

Dynamic contrast-enhanced MR imaging findings of bone metastasis in patients with prostate cancer

Dynamic contrast-enhanced MR imaging findings of bone metastasis in patients with prostate cancer

Degenerative endplate changes of the lumbosacral spine: Dynamic contrast‐enhanced MRI profiles related to age, sex, and spinal level

Neovascularization of bone marrow in patients with diffuse multiple myeloma

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