Detection of malignant soft tissue tumors in bone imaging

Vorne, M; Saukko, T.

doi:10.1007/bf00251468

Cited by 10 publications

(3 citation statements)

References 31 publications

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“…In our earlier studies it was demonstrated that " m Tc-GP accumulated in pathological but not in normal bone tissue (2,3). Accumulation of " m Tc-labelled phosphate compounds in soft-tissue tumors was also reported by Vorne and Sauk- ko (9). The present study was undertaken in a large group of patients to investigate the potential of " m Tc-GP as a radiopharmaceutical in demonstrating bone pathologies in comparison with 9t)m Tc-MDP and lung cancer in comparison with 67 Ga-citrate.…”

Section: Introductionsupporting

confidence: 64%

“…Being a glucose analogue its uptake mechanism was thought to be through active transport by metabolically active tumor tissue, like that of 18 F-deoxyglucose (6,10) and N-( 18 F)-fluoroacetyl-D-glucos- amine (5). A similar compound, " m T cglucoheptonate, was also reported to accumulate in lung tumors (9). However, GP contains a phosphate group facilitating " m T c labelling, and consequently its in vivo behavior might be similar to that of the other " m T clabelled phosphate compounds used for bone imaging.…”

Section: Introductionmentioning

confidence: 99%

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Visualization of Bone Pathologies and Lung Cancer with 99mTc-Glucose Phosphate: A Comparative Study

Be¹,

Mt²,

Cf³

et al. 1991

Nuklearmedizin

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Glucose phosphate (GP) labelled with 99mTc was used to obtain scintigraphic images of bone lesions in one group of patients (n = 28) and of lung tumors in another (n = 35). All bone lesions detected by 99mTc-MDP were also demonstrated by 99mTc-GP; all lung tumors except 4 were detected by 99mTc-GP, the failure rate being about the same as that for 67Ga. The use of 99mTc-GP is preferable to that of 99mTc-MDP because the former does not accumulate in normal bone; the advantage of 99mTc-GP over 67Ga lies in its better physical characteristics and in the fact that the result of the study is available within a few hours rather than three days.

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Section: Introductionsupporting

confidence: 64%

Section: Introductionmentioning

confidence: 99%

Visualization of Bone Pathologies and Lung Cancer with 99mTc-Glucose Phosphate: A Comparative Study

Be¹,

Mt²,

Cf³

et al. 1991

Nuklearmedizin

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“…The fact that mesothelioma tumors have been reported to accumulate Tc-99m hydroxymethylene diphosphonate in patients with mesothelioma suggests that these cells may possess a yet to be identified mechanism to accumulate bisphosphonates, which may also explain their in vivo sensitivity to these drugs. Such an extraosseous accumulation of the bone scanning agent has also been described for several other epithelial cancer cells, including small cell lung cancer (19,22,34). Interestingly, it was shown recently that treatment with zoledronate also significantly inhibited the growth of small cell lung cancer cells in the flanks of nude mice (35).…”

Section: Discussionmentioning

confidence: 57%

Bisphosphonates Inhibit the Growth of Mesothelioma Cells In vitro and In vivo

Wakchoure

Merrell

Aldrich

et al. 2006

Clinical Cancer Research

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Purpose: Bisphosphonates (such as risedronate and zoledronate) are widely used inhibitors of bone resorption. Despite their in vitro antiproliferative effects in various cancer cells, bisphosphonates have not exhibited significant antitumor efficacy in animal models of visceral cancer, which may be due to their poor bioavailability. The diagnostic use of radioactive bisphosphonates has revealed the accumulation of bisphosphonates in mesothelioma, which prompted us to test the antitumor efficacy of bisphosphonates in this disease. Experimental Design and Results: Treatment with either risedronate or zoledronate (2 Â 10 À4 to 2 Â 10 À6 mol/L) inhibited the growth of AB12 and AC29 mouse mesothelioma cells and induced the accumulation of unprenylated Rap1A in these cells. Both these in vitro effects were reversed by geranygeraniol, an end product of the mevalonate pathway that these bisphosphonates inhibit. Both bisphosphonates also induced the phosphorylation of the p38 mitogen-activated protein kinase in AB12 and AC29 cells. The inhibition of p38 augmented bisphosphonate-induced growth inhibition in these cells. Bisphosphonate-induced p38 phosphorylation was not reversible by geranylgeraniol. Risedronate (15 mg/kg) and zoledronate (0.5 mg/kg) inhibited the growth of s.c. tumors and increased the median survival of mice with i.p. mesothelioma tumors in vivo. Discussion: In conclusion, risedronate and zoledronate inhibit the mevalonate pathway and induce p38 activation in mesothelioma cells in vitro. The effects on the mevalonate pathway dominate because the net result is growth inhibition. Both bisphosphonates also inhibit mesothelioma tumor growth in vivo and prolong the survival of mesothelioma-bearing mice. These results support further study of bisphosphonates in the management of mesothelioma.Mesothelioma, an asbestos-related neoplasm of the pleural and peritoneal space, occurs in f10,000 patients worldwide (1). Due to the long latency period for tumor development and the widespread use of asbestos for many years, the incidence is expected to rise until the year 2020 (2). The biological behavior is distinct from other solid tumors in that mesothelioma tends to grow in a sheet-like fashion, covering the surface of the pleura or peritoneum. It shows little tendency to invade, especially early in the course of the disease (3). Mesothelioma typically recurs even after the most aggressive attempts at surgical resection and is poorly responsive to radiotherapy and chemotherapy. Multimodality approaches have had a relatively small effect on the majority of the patients and have been associated with toxicity. The survival of patients with mesothelioma ranges between 4 and 12 months (4, 5). Clearly, new treatment modalities are needed.Bisphosphonates are synthetic analogues of the naturally occurring pyrophosphate. Depending on their molecular structure, these drugs can be divided into pyrophosphateresembling (p-bisphosphonates, such as clodronate) and nitrogen-containing bisphosphonates (n-bisphosphonates, su...

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Neoplasms and Mass Lesions Involving Muscle

Weatherall¹,

Maale²

1996

Muscle Imaging in Health and Disease

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Detection of malignant soft tissue tumors in bone imaging

Cited by 10 publications

References 31 publications

Visualization of Bone Pathologies and Lung Cancer with 99mTc-Glucose Phosphate: A Comparative Study

Visualization of Bone Pathologies and Lung Cancer with 99mTc-Glucose Phosphate: A Comparative Study

Bisphosphonates Inhibit the Growth of Mesothelioma Cells In vitro and In vivo

Neoplasms and Mass Lesions Involving Muscle

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