Detection of parvovirus B19 DNA in the lesional skin of patients with Behçet's disease

Abstract

To the best of our knowledge, this is the first study that provides evidence for a possible causal link between BD and parvovirus B19, and our data suggest the presence of the virus, particularly in intact, nonulcerative skin lesions of BD. Limitations to this study include the limited number of participants, and the fact that the exact source of B19 DNA was undetected.

Behcet’s disease: from heat shock proteins to infections

“…By using quantitative PCR methods and immunofluorescence assays for IgG and IgM to B19, Baskan et al found B19 DNA in the lesional skin samples of patients with BD and statistically significant rate of seropositivity for B19 IgG antibody. By contrast with previous reports, this study provides evidence for a possible causal link between BD and parvovirus B19 [132].…”

Recurrent aphthous stomatitis may be a precursor or risk factor for specific cancers: A case‐control frequency‐matched study

“…The underlying cause of RAS is unknown. Similar to autoimmune diseases, RAS may represent aberrant immune system activity resulting from exposure to a possibly infectious agent46, 47, 48, 49, 50 in patients genetically predisposed to develop RAS 46, 51, 52, 53, 54. Proposed triggering agents include viral and bacterial antigens and other environmental sources 46, 47, 48, 49, 50.…”

“…Genetic predisposition to RAS is likely polygenic. Genetic influences associated with RAS include certain human leukocyte antigens (HLAs), including HLA‐B51; however, both HLA and non‐HLA genes may play a role in the disorder 46, 51, 52, 53, 54. Studies have suggested that altered innate immune function may contribute to RAS 55, 56, 57, 58, 59.…”

Serum visfatin levels in Behçet's disease

“…Etiyolojisi tam olarak aydınlatılamamıştır. BH'nin etyopatogenezi ile ilgili günümüzde yaygın olan görüş genetik olarak hastalığa yatkın bireyde, çevresel faktör olarak enfeksiyon ajanları veya ısı şok proteinleri ile immün sisteminin uyarılarak hastalığın başladığı yönündedir [2][3][4] . İnfeksiyöz ajanlardan en çok üzerinde durulan HSV-1'dir (Herpes simplex virüs -1).…”

“…BH alevlenme ve iyilik dönemleri ile seyreden kronik enflamatuvar bir vaskülittir 1 . Genetik faktörler ve HLA tipleri, infeksiyöz ajanlar, ısı şok proteinleri, endotel hücre disfonksiyonu, oksidatif stres, self-antijenler ile humoral ve hücresel immünitede değişiklikler hastalığın etiyolojisinde yer almaktadır [2][3][4] . T hücreleri ve nötrofillerin aktivasyonu hastalığın patogenezinde önemli role sahiptir.…”