Detection of phytocannabinoids from buccal swabs by headspace solid phase microextraction – gas chromatography/mass spectrometry

Franklin, Tiffany; Perry, L.M.; Shih, Wei-Chuan; Yu, Jorn C. C.

doi:10.1039/c7ay02996a

Cited by 8 publications

(2 citation statements)

References 37 publications

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“…The presence of MSTFA effectively derivatized the neutral cannabinoids enhancing the sensitivity of the determination. However, an earlier derivatization of the acidic cannabinoids is necessary since the performance of the headspace derivatization in this case was not so effective [37].…”

Section: Interassaymentioning

confidence: 99%

Exploring the Mysteries of Cannabis through Gas Chromatography

García-Valverde¹,

Medina²,

Codesido³

et al. 2022

Recent Advances in Gas Chromatography

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In the last decades, cannabinoids, the active constituents of Cannabis sativa L., have been attracting a strong interest, regarding the health effects associated with the use of Cannabis and Cannabis-derived products. The progressive legalization of this species in several countries has prompted an increasing concern about the characterization and quantification of cannabinoids in diverse chemotypes of the plant, as well as the obtained final products. Therewith, Process and Product Quality Assurance (PPQA) becomes a mandatory practise to verify the Good Manufacturing Practices (GMP). Gas chromatography is one of the most used techniques in this sense due to its high attainable resolution. However, sample complexity and the thermal lability of cannabinoids hinder the analysis. In this chapter, a fully description of the recent advances in the Cannabis sativa L. analysis by gas chromatography will be presented, including different approaches that have come up to solve the obstacles encountered.

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Section: Interassaymentioning

confidence: 99%

Exploring the Mysteries of Cannabis through Gas Chromatography

García-Valverde¹,

Medina²,

Codesido³

et al. 2022

Recent Advances in Gas Chromatography

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“…Table 4 summarizes in detail these miniaturized applications for the enrichment of cannabinoids and related substances in forensic matrices, with emphasis on the key characteristics on the developed methodologies. Table S4 (Supplementary Material) contains information regarding other techniques for the determination of these classes of compounds in the forensic context [ 89 , 100 , 205 , 206 , 207 , 208 , 209 , 210 , 211 , 212 , 213 , 214 , 215 , 216 , 217 , 218 , 219 ].…”

Section: Screening-controlled Drugs By Microextraction-based Techniquesmentioning

confidence: 99%

Application of Microextraction-Based Techniques for Screening-Controlled Drugs in Forensic Context—A Review

et al. 2021

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The analysis of controlled drugs in forensic matrices, i.e., urine, blood, plasma, saliva, and hair, is one of the current hot topics in the clinical and toxicological context. The use of microextraction-based approaches has gained considerable notoriety, mainly due to the great simplicity, cost-benefit, and environmental sustainability. For this reason, the application of these innovative techniques has become more relevant than ever in programs for monitoring priority substances such as the main illicit drugs, e.g., opioids, stimulants, cannabinoids, hallucinogens, dissociative drugs, and related compounds. The present contribution aims to make a comprehensive review on the state-of-the art advantages and future trends on the application of microextraction-based techniques for screening-controlled drugs in the forensic context.

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