Detection of Plasmid-Mediated KPC-Producing
            <i>Klebsiella pneumoniae</i>
            in Ottawa, Canada: Evidence of Intrahospital Transmission

Goldfarb, David M.; Harvey, Sarah-Beth; Jessamine, K.; Jessamine, Peter; Toye, Baldwin; Desjardins, Marc

doi:10.1128/jcm.00098-09

Cited by 46 publications

(28 citation statements)

References 18 publications

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“…In 2008, 10 isolates of K. pneumoniae were referred to the Ontario Public Health Laboratories for further testing. 11,12 The initial results of susceptibility testing of 1 of the 10 isolates using an automated method suggested that the organism was susceptible to meropenem. However, the initial results of testing using routine clinical laboratory methods showed general resistance to all lactams, with complete or intermediate resistance to meropenem, which raised the possibility of KPC production.…”

Section: Diagnosismentioning

confidence: 99%

Carbapenem resistance in Canada

Toye¹,

Krajden²,

Fuksa³

et al. 2009

Canadian Medical Association Journal

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Section: Diagnosismentioning

confidence: 99%

Carbapenem resistance in Canada

Toye¹,

Krajden²,

Fuksa³

et al. 2009

Canadian Medical Association Journal

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“…In particular, K. pneumoniae isolates producing KPC carbapenemases (KPC-Kp) are spreading at an alarming rate in North and South America, the Caribbean, Europe, Israel, and Asia (6,7,15,17,18). Like ESBL producers, KPC-Kp are often resistant to quinolones and aminoglycosides (6).…”

mentioning

confidence: 99%

ACHN-490, a Neoglycoside with Potent In Vitro Activity against Multidrug-Resistant Klebsiella pneumoniae Isolates

Endimiani

Hujer

et al. 2009

Antimicrob Agents Chemother

101

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The in vitro activity of ACHN-490, a novel aminoglycoside ("neoglycoside"), was evaluated against 102 multidrug-resistant (MDR) Klebsiella pneumoniae strains, including a subset of 25 strains producing the KPC carbapenemase. MIC 50 values for gentamicin, tobramycin, and amikacin were 8 g/ml, 32 g/ml, and 2 g/ml, respectively; MIC 90 values for the same antimicrobials were >64 g/ml, >64 g/ml, and 32 g/ml, respectively. ACHN-490 showed an MIC 50 of 0.5 g/ml and an MIC 90 of 1 g/ml, which are significantly lower than those of comparator aminoglycosides. ACHN-490 represents a promising aminoglycoside for the treatment of MDR K. pneumoniae isolates, including those producing KPC ␤-lactamase.

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“…terdiri dari 3 jenis porin yaitu OmpK35, OmpK36, dan OmpK37 (Hernandez-Alles et al, 1999;Kaczmarek et al, 2006). Porin OmpK35 dan OmpK36 berperan penting pada penetrasi antibiotik ke dalam sel, sehingga hilangnya porin OmpK35 dan OmpK36 dapat menyebabkan resistensi bakteri terhadap carbapenem (Doumith et al, 2009;Goldfarb et al, 2009;Kontopoulou et al, 2010).…”

Section: H a S I L D A N P E M B A H A S A Nunclassified

RESISTENSI <em>Klebsiella</em> sp TERHADAP MEROPENEM DI RSUD PROF. DR. MARGONO SOEKARJO PURWOKERTO

2017

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Resistant Gram-negative bacteria, particularly Klebsiella sp., has become a serious problem in hospitals as one of the main causes of nosocomial infections spread through urine catheterization. Infections of Klebsiella sp. producing extended-spectrum beta-lactamase (ESBL) can lead to significant economic and clinical negative outcome. This study was aimed to determine the sensitivity of ESBL Klebsiella sp. against meropenem as a cause of nosocomial infections in Prof. Dr. Margono Soekarjo hospital. This research obtained urine samples from the urinary catheter of patients hospitalized for at least two days in the surgical ward and intensive care unit. ESBL examination conducted by the initial screen test, meanwhile, sensitivity test to meropenem done by using disk diffusion test. Among the 40 patients examined in this study 7.5% isolates were Klebsiella sp-positive. This research identified five percent of the total patients as ESBL positive with the level of sensitivity against meropenem was revealed as resistant.

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Detection of Plasmid-Mediated KPC-Producing Klebsiella pneumoniae in Ottawa, Canada: Evidence of Intrahospital Transmission

Cited by 46 publications

References 18 publications

Carbapenem resistance in Canada

Carbapenem resistance in Canada

ACHN-490, a Neoglycoside with Potent In Vitro Activity against Multidrug-Resistant Klebsiella pneumoniae Isolates

RESISTENSI <em>Klebsiella</em> sp TERHADAP MEROPENEM DI RSUD PROF. DR. MARGONO SOEKARJO PURWOKERTO

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