Detection of quantitative trait loci for porcine susceptibility to enterotoxigenic Escherichia coli F41 in a White Duroc × Chinese Erhualian resource population

Yang, Bin; Huang, Xiaowan; Yan, Xueming; Ren, Jun; Yang, Seungho; Zou, Zhengzhi; Zeng, Weihong; Ou, Yuan; Huang, Weibing; Huang, Lusheng

doi:10.1017/s1751731109004509

Cited by 5 publications

(3 citation statements)

References 27 publications

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“…An intestinal receptor for the F41 fimbriae remains to be identified, although it might include N-acetylglucosamine in a carbohydrate group that mimics one on glycophorin A M , as determined by hemagglutination assays (120, 183). A quantitative trait locus (QTL) with a suggested candidate gene (ST3GAL1) was found on Chromosome 4 (SSC4) (184). …”

Section: Adhesins and Host Receptorsmentioning

confidence: 99%

Animal EnterotoxigenicEscherichia coli

2016

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Enterotoxigenic Escherichia coli (ETEC) is the most common cause of E. coli diarrhea in farm animals. ETEC are characterized by the ability to produce two types of virulence factors; adhesins that promote binding to specific enterocyte receptors for intestinal colonization and enterotoxins responsible for fluid secretion. The best-characterized adhesins are expressed in the context of fimbriae, such as the F4 (also designated K88), F5 (K99), F6 (987P), F17 and F18 fimbriae. Once established in the animal small intestine, ETEC produces enterotoxin(s) that lead to diarrhea. The enterotoxins belong to two major classes; heat-labile toxin that consist of one active and five binding subunits (LT), and heat-stable toxins that are small polypeptides (STa, STb, and EAST1). This chapter describes the disease and pathogenesis of animal ETEC, the corresponding virulence genes and protein products of these bacteria, their regulation and targets in animal hosts, as well as mechanisms of action. Furthermore, vaccines, inhibitors, probiotics and the identification of potential new targets identified by genomics are presented in the context of animal ETEC.

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Section: Adhesins and Host Receptorsmentioning

confidence: 99%

Animal EnterotoxigenicEscherichia coli

2016

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“…17 To date, it is not known whether the presence of the receptor for F41 is genetically determined, as is the receptor for F4ab/ac. In the population of crossbred pigs used in the present study, we have previously mapped a significant quantitative trait locus for susceptibility to ETEC F41 on porcine chromosome 4 (SSC4) by use of a genome scan, 29 shedding light on the genetic basis of the F41 receptor.…”

Section: Discussionmentioning

confidence: 99%

Adhesion phenotypes of pigs of Chinese and Western breeds and a White Duroc-Erhualian crossbreed with regard to susceptibility to enterotoxigenic Escherichia coli with fimbrial adhesins K99, 987P, and F41

Yan

Huang²,

Ren³

et al. 2011

ajvr

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“…A total of 40 QTLs were identified for Samonella count in liver and spleen [24]. Six QTLs were identified for resistance to E. coli [25]. No studies were attempted to identify QTLs for other gram negative bacteria.…”

Section: General Consideration Of Disease Resistancementioning

confidence: 99%

Immunogenomics for identification of disease resistance genes in pigs: a review focusing on Gram-negative bacilli

Song

Zhu

Chen

2012

J Animal Sci Biotechnol

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Over the past years, infectious disease has caused enormous economic loss in pig industry. Among the pathogens, gram negative bacteria not only cause inflammation, but also cause different diseases and make the pigs more susceptible to virus infection. Vaccination, medication and elimination of sick pigs are major strategies of controlling disease. Genetic methods, such as selection of disease resistance in the pig, have not been widely used. Recently, the completion of the porcine whole genome sequencing has provided powerful tools to identify the genome regions that harboring genes controlling disease or immunity. Immunogenomics, which combines DNA variations, transcriptome, immune response, and QTL mapping data to illustrate the interactions between pathogen and host immune system, will be an effective genomics tool for identification of disease resistance genes in pigs. These genes will be potential targets for disease resistance in breeding programs. This paper reviewed the progress of disease resistance study in the pig focusing on Gram-negative bacilli. Major porcine Gram-negative bacilli and diseases, suggested candidate genes/pathways against porcine Gram-negative bacilli, and distributions of QTLs for immune capacity on pig chromosomes were summarized. Some tools for immunogenomics research were described. We conclude that integration of sequencing, whole genome associations, functional genomics studies, and immune response information is necessary to illustrate molecular mechanisms and key genes in disease resistance.

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Detection of quantitative trait loci for porcine susceptibility to enterotoxigenic Escherichia coli F41 in a White Duroc × Chinese Erhualian resource population

Cited by 5 publications

References 27 publications

Animal EnterotoxigenicEscherichia coli

Animal EnterotoxigenicEscherichia coli

Adhesion phenotypes of pigs of Chinese and Western breeds and a White Duroc-Erhualian crossbreed with regard to susceptibility to enterotoxigenic Escherichia coli with fimbrial adhesins K99, 987P, and F41

Immunogenomics for identification of disease resistance genes in pigs: a review focusing on Gram-negative bacilli

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