Detection of Saccular Endolymphatic Hydrops in Ménière's Disease Using a Modified Glycerol cVEMP Test in Combination With the Tuning Property Test

Murofushi, Toshihisa; Komiyama, Sakurako; Suizu, Ryota

doi:10.1097/mao.0000000000001149

Cited by 18 publications

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References 21 publications

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“…MR imaging requires high costs and is currently used in a research setting (3). Therefore, the physiological confirmation of EH is still useful for diagnosis of EH in MD (4). For detection of EH in the cochlea, electrocochleography (5) and glycerol test using improvement of pure-tone hearing as an index (6) have been used, while for detection of EH in the semicircular canal, furosemide test has been used (7).…”

Section: Introductionmentioning

confidence: 99%

“…The one is the glycerol cervical vestibular-evoked myogenic potential (cVEMP) test, and the other is the tuning property test of cVEMP (4). Traditionally, glycerol has been used for the test of EH in the cochlea because glycerol temporally reduces EH in the inner ear (6).…”

Section: Introductionmentioning

confidence: 99%

“…Then, improvement of pure-tone hearing after glycerol administration was regarded as a sign suggestive of EH in the cochlea. Recently, glycerol administration has been applied to cVEMP test, a test of functions of the saccule, to detect EH in the saccule (4). As glycerol cVEMP test, improvement of cVEMP responses was assessed after intravenous infusion of 10% glycerol (500 ml, 2 h) (4).…”

Section: Introductionmentioning

confidence: 99%

“…Recently, glycerol administration has been applied to cVEMP test, a test of functions of the saccule, to detect EH in the saccule (4). As glycerol cVEMP test, improvement of cVEMP responses was assessed after intravenous infusion of 10% glycerol (500 ml, 2 h) (4). The positivity rate (PR) of glycerol cVEMP test was 60% (12/20) in definite MD patients when significant improvement of cVEMP amplitude (p13–n23) was adopted as an index.…”

Section: Introductionmentioning

confidence: 99%

“…Murofushi et al calculated 500–1,000 Hz cVEMP slope to quantify this frequency preference (see Methods in this article) (11). According to Murofushi et al (4), PR of tuning property test in definite MD ears was 69% (11/16) when totally cVEMP-absent patients were excluded. In that study, the cutoff point was set using mean − 2SD of the healthy subjects.…”

Section: Introductionmentioning

confidence: 99%

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Is Alteration of Tuning Property in Cervical Vestibular-Evoked Myogenic Potential Specific for Ménière’s Disease?

et al. 2017

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ObjectiveThe aim of this study is to show sensitivity and specificity of cervical vestibular-evoked myogenic potential (cVEMP) tuning property test to Ménière’s disease (MD) in comparison with healthy controls (HC) and patients with other vestibular diseases.SubjectsTotally 92 subjects (50 women and 42 men, 20–77 years of age) were enrolled in this study. Subjects were composed of 38 definite unilateral MD patients, 11 unilateral benign paroxysmal positional vertigo patients, 14 vestibular migraine patients, 19 unilateral vestibular neuritis patients, and 10 HC.MethodsThe subjects underwent cVEMP testing to 500 and 1,000 Hz short tone bursts (125 dBSPL). The corrected amplitudes of the first biphasic responses (p13–n23) (cVEMP) were measured. Then, a tuning property index (the 500–1,000 Hz cVEMP slope) was calculated.ResultsThe area of under the ROC curve (AUC) was 0.75 in comparison with other vestibular disease patients, while AUC was 0.77 in comparison with other vestibular disease patients plus HC. The best cutoff point of the 500–1,000 Hz cVEMP slope was −19.9. Sensitivity of the tuning property test to MD was 0.74, while specificity was 0.76 to other vestibular disease patients.ConclusionThe tuning property test of cVEMP is useful as a screening test of MD.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Is Alteration of Tuning Property in Cervical Vestibular-Evoked Myogenic Potential Specific for Ménière’s Disease?

et al. 2017

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Association of cervical vestibular-evoked myogenic potential tuning property test results with MRI findings of endolymphatic hydrops in Meniere’s disease

Murofushi

Tsubota

Kanai

et al. 2020

Eur Arch Otorhinolaryngol

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Vestibular migraine or Meniere's disease: a diagnostic dilemma

et al. 2022

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Meniere’s disease (MD) represents one of the vertigo disorders characterized by triad symptoms (recurrent vertigo, fluctuating hearing loss, tinnitus or ear fullness). The diagnosis of MD relies on the accurate and detailed taking of medical history, and the differentiation between MD and vestibular migraine (VM) is of critical importance from the perspective of the treatment efficacy. VM is a highly prevalent vertigo condition and its typical symptoms (headache, vestibular symptoms, cochlear symptoms) mimic those of MD. Furthermore, the misdiagnosis in MD and VM could lead to VM patients mistakenly receiving the traumatic treatment protocol designed for MD, and sustaining unnecessary damage to the inner ear. Fortunately, thanks to the advances in examination technologies, the barriers to their differentiation are being gradually removed. These advances enhance the diagnostic accuracy of vertigo diseases, especially VM and MD. This review focused on the differentiation of VM and MD, with an attempt to synthesize existing data on the relevant battery of differentiation diagnosis (covering core symptoms, auxiliary tests [audiometry, vestibular tests, endolymphatic hydrops tests]) and longitudinal follow-up. Since the two illnesses are overlapped in all aspects, no single test is sufficiently specific on its own, however, patterns containing all or at least some features boost specificity.

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Detection of Saccular Endolymphatic Hydrops in Ménière's Disease Using a Modified Glycerol cVEMP Test in Combination With the Tuning Property Test

Abstract: The tuning property test is an easy and useful way of detecting saccular EH. However, the glycerol cVEMP test is required in patients that do not respond to either 500 or 1000 Hz short tone bursts (STB).

Cited by 18 publications

References 21 publications

Is Alteration of Tuning Property in Cervical Vestibular-Evoked Myogenic Potential Specific for Ménière’s Disease?

Is Alteration of Tuning Property in Cervical Vestibular-Evoked Myogenic Potential Specific for Ménière’s Disease?

Association of cervical vestibular-evoked myogenic potential tuning property test results with MRI findings of endolymphatic hydrops in Meniere’s disease

Vestibular migraine or Meniere's disease: a diagnostic dilemma

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