Detection of severe fever with thrombocytopenia syndrome virus and other viruses in cats via unbiased next-generation sequencing

Momoi, Yasuyuki; Matsuu, Aya

doi:10.1177/1040638720967506

Cited by 8 publications

(8 citation statements)

References 25 publications

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“…We have continuously attempted to detect unknown viruses using blood from cases of fever of unknown origin. In this study, we applied an NGS-based comprehensive virus detection method described previously [ 10 ] with some modifications. A heparinized plasma sample was obtained from a cat with fever of unknown cause (Case 1), and total nucleic acids (DNA and RNA) were extracted from 200 μL of the sample using the NucleoSpin Virus kit (Machery-Nagel, Düren, Germany).…”

Section: Methodsmentioning

confidence: 99%

Detection of domestic cat hepadnavirus by next-generation sequencing and epidemiological survey in Japan

Sakamoto

Ito

Goto‐Koshino

et al. 2023

The Journal of Veterinary Medical Science

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The novel domestic cat hepadnavirus (DCH), a member of the Hepadnaviridae , was first detected in Australia and has recently been identified in more countries. In this study, we explored the DCH genome using next-generation sequencing of a plasma sample from a cat with a fever of unknown cause. Nucleotide sequence analysis showed the virus to be relatively genetically distant from the first reported DCH in Australia, showing 89% homology. Then we conducted an epidemiological survey by PCR of plasma samples collected from 203 cats that visited a veterinary hospital for diagnosis and treatment. Two of the 203 surveyed cats a were positive for DCH. One of the two positive cases had elevated liver enzymes of unknown etiology, and the other had hepatocellular adenoma. Our study indicated that DCH infection was observed in domestic cats in the Tokyo area of Japan as well as other reported areas in the world. Further investigations are needed to define the clinical importance of DCH.

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Section: Methodsmentioning

confidence: 99%

Detection of domestic cat hepadnavirus by next-generation sequencing and epidemiological survey in Japan

Sakamoto

Ito

Goto‐Koshino

et al. 2023

The Journal of Veterinary Medical Science

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“…Similarly, a patient with SFTS, who might have been infected with SFTSV from a companion dog and was virologically diagnosed with SFTSV infection was also reported (67)(68)(69). Diagnoses of SFTSV infection in cats were based on the molecular detection of the SFTSV genome (26,27,61,(70)(71)(72). CFRs of cats with SFTSV infection in Nagasaki and Kagoshima Prefectures in Japan were 58.0% (22/38) and 62.5% (15/24), respectively, suggesting that SFTSV infections cause a severe and fatal disease in cats (70,71).…”

Section: Cats and Dogsmentioning

confidence: 98%

Severe Fever with Thrombocytopenia Syndrome, a Viral Hemorrhagic Fever, Endemic to Japan: Achievements in and Directions for Medical Research

Saijo

2022

Jpn J Infect Dis

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Severe fever with thrombocytopenia syndrome (SFTS), a novel infectious disease caused by a novel bunyavirus and with a high case fatality rate (CFR), was reported by Chinese scientists in 2011. The causative virus, Dabie bandavirus also known as the SFTS virus (SFTSV), belongs to the genus Bandavirus (formerly named Phlebovirus) of the family Phenuiviridae (formerly named Bunyaviridae). SFTS was also reported to be endemic in South Korea and Japan in 2013. SFTSV circulates between some species of ticks and animals in nature. Humans are infected with SFTSV through bites from ticks such as Haemaphysalis longicornis and Amblyomma testidinarium. Domesticated animals, such as cats and dogs, are also infected with SFTSV and shown SFTS-like symptoms with a high CFR, likely having been infected through tick bites in the living environment. Furthermore, there have been cases of patients with SFTS who were infected with SFTSV through close contact with sick cats or dogs. The CFR in patients with SFTS is approximately 30% in Japan. There is always a risk of SFTSV infection in human populations living in endemic areas. Therefore, the development of specific therapies and vaccines is urgently needed to reduce the number of fatal SFTS cases.

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“…However, this could be different in noncontrolled situations where host and virus variables could lead to different outcomes. This gap of knowledge has been investigated by Ito et al (2023) [60] after the detection of FeMV in a cat that was subjected to an investigation of unknown viruses as part of a study in cats with fever using unbiased next-generation sequencing [61]. The retrospective controlled study was performed in an area endemic for the zoonotic severe fever with thrombocytopenia syndrome (SFTS) caused in East Asia by Huaiyangshanbanyang virus; most of the studied cats had fever, leukopenia, thrombocytopenia, and jaundice, but SFTS and parvovirus infections had been excluded by blood PCR [61].…”

Section: Acute Femv Infection As Defined In Cats By Experimental Mode...mentioning

confidence: 99%

Feline Morbillivirus: Clinical Relevance of a Widespread Endemic Viral Infection of Cats

Pennisi,

Belák,

Tasker

et al. 2023

Viruses

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Feline morbillivirus (FeMV) was first isolated in 2012 from stray cats in Hong Kong. It has been found in association with tubulointerstitial nephritis (TIN), the most common cause of feline chronic kidney disease (CKD). However, viral host spectrum and virus tropism go beyond the domestic cat and kidney tissues. The viral genetic diversity of FeMV is extensive, but it is not known if this is clinically relevant. Urine and kidney tissues have been widely tested in attempts to confirm associations between FeMV infection and renal disease, but samples from both healthy and sick cats can test positive and some cross-sectional studies have not found associations between FeMV infection and CKD. There is also evidence for acute kidney injury following infection with FeMV. The results of prevalence studies differ greatly depending on the population tested and methodologies used for detection, but worldwide distribution of FeMV has been shown. Experimental studies have confirmed previous field observations that higher viral loads are present in the urine compared to other tissues, and renal TIN lesions associated with FeMV antigen have been demonstrated, alongside virus lymphotropism and viraemia-associated lymphopenia. Longitudinal field studies have revealed persistent viral shedding in urine, although infection can be cleared spontaneously.

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Detection of severe fever with thrombocytopenia syndrome virus and other viruses in cats via unbiased next-generation sequencing

Cited by 8 publications

References 25 publications

Detection of domestic cat hepadnavirus by next-generation sequencing and epidemiological survey in Japan

Detection of domestic cat hepadnavirus by next-generation sequencing and epidemiological survey in Japan

Severe Fever with Thrombocytopenia Syndrome, a Viral Hemorrhagic Fever, Endemic to Japan: Achievements in and Directions for Medical Research

Feline Morbillivirus: Clinical Relevance of a Widespread Endemic Viral Infection of Cats

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