Detection of Telomerase Activity: A New Strategy for Detecting Low Activity of Telomerase

Hosseini-Asl, S.S.; Mehdipour, Parvin

doi:10.1007/978-94-007-4632-9_3

Cited by 1 publication

(2 citation statements)

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“…Mehdipour [16] Utility of budding to identify a large multi-subunit RNP enzyme (383 kDa, including hTERT-Cdc13 and hTR.…”

Section: References Findings Referencesmentioning

confidence: 99%

“…Telomerase is tightly regulated in several levels, including transcriptional and post-transactional. On one side, alternative splicing has an essential role in the regulation of hTERT mRNA expression [13,15], and on the other side, studies have shown that telomerase function is regulated by post-translational regulation in serine/ threonine or tyrosine residue of hTERT [16]. In addition, several factors including p53, c-myc, AKT kinase, sp1, WT1, NF1, c-myb, AP1, and C-Ets2 regulate the catalytic subunits of telomerase [17][18][19][20][21][22].…”

Section: Introductionmentioning

confidence: 99%

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Biological and Molecular Diversity in Telomerase: Characteristics of hTERT in Human, Vertebrates and Yeast

Abdollahi¹,

Mehdipour²

2016

Cell Dev Biol

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hTERT (human telomerase reverse transcriptase) is the catalytic subunit of telomerase enzyme, and is essential for its functions. The aim of this review was to compare the TERT in human and other species including microorganism, vertebrates and mammals, in terms of its functions and regulation. According to literature, the catalytic subunit of telomerase in animals contains many conserved domains and residues, which have crucial roles in its functions. Moreover, the structure and biology of human telomerase seem to be more similar to that of dog compared other animals. Thus interestingly, unlike the mouse that is seemingly not a proper model for evaluation of telomerase activity and its regulation, dog may be an appropriate model for the experimental investigations of telomerase function and therapeutic strategies in cancer studies.

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“…Mehdipour [16] Utility of budding to identify a large multi-subunit RNP enzyme (383 kDa, including hTERT-Cdc13 and hTR.…”

Section: References Findings Referencesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Biological and Molecular Diversity in Telomerase: Characteristics of hTERT in Human, Vertebrates and Yeast

Abdollahi¹,

Mehdipour²

2016

Cell Dev Biol

View full text Add to dashboard Cite

show abstract

Detection of Telomerase Activity: A New Strategy for Detecting Low Activity of Telomerase

Cited by 1 publication

References 31 publications

Biological and Molecular Diversity in Telomerase: Characteristics of hTERT in Human, Vertebrates and Yeast

Biological and Molecular Diversity in Telomerase: Characteristics of hTERT in Human, Vertebrates and Yeast

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